E-cadherin in contact inhibition and cancer

E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expressi...

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Bibliographic Details
Published in:	Oncogene Vol. 37; no. 35; pp. 4769 - 4780
Main Authors:	Mendonsa, Alisha M., Na, Tae-Young, Gumbiner, Barry M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.08.2018 Nature Publishing Group
Subjects:	631/67/322 631/80/79/1902 Adherens junctions Apoptosis Biochemistry Cadherins Cancer Cancer prevention Cancer treatment Cell adhesion Cell adhesion & migration Cell Biology Cell proliferation Cellular signal transduction Contact inhibition Developmental biology E-cadherin Embryonic development Gene expression Genetic aspects Health aspects Homeostasis Human Genetics Innovations Internal Medicine Medical schools Medicine Medicine & Public Health Oncology Pediatrics Phenotypes Proteins Review Article Universities and colleges
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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