E-cadherin in contact inhibition and cancer

E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expressi...

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Bibliographic Details
Published in:	Oncogene Vol. 37; no. 35; pp. 4769 - 4780
Main Authors:	Mendonsa, Alisha M., Na, Tae-Young, Gumbiner, Barry M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.08.2018 Nature Publishing Group
Subjects:	631/67/322 631/80/79/1902 Adherens junctions Apoptosis Biochemistry Cadherins Cancer Cancer prevention Cancer treatment Cell adhesion Cell adhesion & migration Cell Biology Cell proliferation Cellular signal transduction Contact inhibition Developmental biology E-cadherin Embryonic development Gene expression Genetic aspects Health aspects Homeostasis Human Genetics Innovations Internal Medicine Medical schools Medicine Medicine & Public Health Oncology Pediatrics Phenotypes Proteins Review Article Universities and colleges
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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Abstract	E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer.
AbstractList	E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer. E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer.E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer.
Audience	Academic
Author	Na, Tae-Young Gumbiner, Barry M. Mendonsa, Alisha M.
Author_xml	– sequence: 1 givenname: Alisha M. surname: Mendonsa fullname: Mendonsa, Alisha M. email: alisha.mendonsa@seattlechildrens.org organization: Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute – sequence: 2 givenname: Tae-Young surname: Na fullname: Na, Tae-Young organization: Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute – sequence: 3 givenname: Barry M. surname: Gumbiner fullname: Gumbiner, Barry M. organization: Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington School of Medicine, Department of Biochemistry, University of Washington School of Medicine
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29780167$$D View this record in MEDLINE/PubMed
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Snippet	E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin...
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SubjectTerms	631/67/322 631/80/79/1902 Adherens junctions Apoptosis Biochemistry Cadherins Cancer Cancer prevention Cancer treatment Cell adhesion Cell adhesion & migration Cell Biology Cell proliferation Cellular signal transduction Contact inhibition Developmental biology E-cadherin Embryonic development Gene expression Genetic aspects Health aspects Homeostasis Human Genetics Innovations Internal Medicine Medical schools Medicine Medicine & Public Health Oncology Pediatrics Phenotypes Proteins Review Article Universities and colleges
Title	E-cadherin in contact inhibition and cancer
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