New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies

Benzimidazole derivatives are known to be key players in the development of novel anticancer agents. Herein, we aimed to synthesize novel derivatives to target breast cancer. A new series of benzimidazole derivatives conjugated with either six- and five-membered heterocyclic ring or pyrazanobenzimid...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Jg. 27; H. 16; S. 5245
Hauptverfasser:	Nashaat, Samira, Henen, Morkos A., El-Messery, Shahenda M., Eisa, Hassan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 01.08.2022 MDPI
Schlagworte:	15N–1H HSQC Acids Amino acids Antineoplastic Agents - chemistry benzimidazole Benzimidazoles - chemistry Breast cancer Breast Neoplasms - drug therapy Cancer Carbon Cell cycle Cell Proliferation computational studies Drug Screening Assays, Antitumor Enzymes Estrogens Female Gene expression Humans Hydrogen Magnetic fields Mass spectrometry MCF-7 Cells Molecular Docking Simulation Molecular Structure NIMA-Interacting Peptidylprolyl Isomerase - metabolism NMR Nuclear Magnetic Resonance, Biomolecular Oncology, Experimental Pin1 inhibitors Scientific imaging Structure-Activity Relationship United States Egypt Pin1 inhibitors benzimidazole breast cancer NMR 15N–1H HSQC computational studies
ISSN:	1420-3049, 1420-3049
Online-Zugang:	Volltext
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