MRI Contrast Agents in Glycobiology

Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both normal and pathological natural processes. Therefore, visualization of these interactions and the extent of expression of the sugars is a challenge in medical diagnosis, monitoring of therapy, and drug design. H...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 27; no. 23; p. 8297
Main Authors: Geraldes, Carlos F. G. C., Peters, Joop A.
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 28.11.2022
MDPI
Subjects:
Biomarkers
Carbohydrates
Chemical properties
Contrast agents
Contrast Media
diagnostic agents
Enzymes
Glycomics
Glycoproteins
lectins
Lectins - metabolism
Magnetic fields
magnetic resonance contrast agents
Magnetic Resonance Imaging
Methods
Molecular weight
Nanoparticles
NMR
Nuclear magnetic resonance
Physiological aspects
Proteins
Review
selectins
theranostics
Tomography
Portugal
diagnostic agents
sialic acid
biomarkers
lectins
glycohemoglobin
theranostics
selectins
asialoglycoprotein receptor
magnetic resonance contrast agents
ISSN:1420-3049, 1420-3049
Online Access:Get full text
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Description
Summary:Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both normal and pathological natural processes. Therefore, visualization of these interactions and the extent of expression of the sugars is a challenge in medical diagnosis, monitoring of therapy, and drug design. Here, we review the literature on the development and validation of probes for magnetic resonance imaging using carbohydrates either as targeting vectors or as a target. Lectins are important targeting vectors for carbohydrate end groups, whereas selectins, the asialoglycoprotein receptor, sialic acid end groups, hyaluronic acid, and glycated serum and hemoglobin are interesting carbohydrate targets.
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238297