Obesity II: Establishing causal links between chemical exposures and obesity

Reducing exposure to obesogens is a strategy for preventing obesity. [Display omitted] •There is an expanding global obesity pandemic.•Ubiquitous environmental chemicals called obesogens play a vital role in the obesity pandemic.•Exposure to obesogens occurs throughout the life course from before co...

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Published in:	Biochemical pharmacology Vol. 199; p. 115015
Main Authors:	Heindel, Jerrold J., Howard, Sarah, Agay-Shay, Keren, Arrebola, Juan P., Audouze, Karine, Babin, Patrick J., Barouki, Robert, Bansal, Amita, Blanc, Etienne, Cave, Matthew C., Chatterjee, Saurabh, Chevalier, Nicolas, Choudhury, Mahua, Collier, David, Connolly, Lisa, Coumoul, Xavier, Garruti, Gabriella, Gilbertson, Michael, Hoepner, Lori A., Holloway, Alison C., Howell, George, Kassotis, Christopher D., Kay, Mathew K., Kim, Min Ji, Lagadic-Gossmann, Dominique, Langouet, Sophie, Legrand, Antoine, Li, Zhuorui, Le Mentec, Helene, Lind, Lars, Monica Lind, P., Lustig, Robert H., Martin-Chouly, Corinne, Munic Kos, Vesna, Podechard, Normand, Roepke, Troy A., Sargis, Robert M., Starling, Anne, Tomlinson, Craig R., Touma, Charbel, Vondracek, Jan, vom Saal, Frederick, Blumberg, Bruce
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 01.05.2022 Elsevier
Subjects:	Adipocyte differentiation Adipogenesis Adipose Tissue Child, Preschool Endocrine disruptor Endocrine Disruptors - toxicity Environmental Exposure - adverse effects Humans Life Sciences Obesity Obesity - etiology Obesogen Pharmaceutical sciences Weight gain DOHaD DiNP HFD PND TCDD PVN DOSS PFNA bHLH IGF1R JECFA BBP TBMEHP PPAR TCDF CMC KCs AgRP Obesity SREBP DOP MiRNA Endocrine disruptor Ces CVD POP AR MCPP ECHA NOAEL TBBPA CART FLD ADHD C/EBP FDA BADGE GNI lncRNA TPhP MRI LXR OPFR CNS HELIX LPL NTP PXR BP TPhT JP-8 DEHP isoDMBs iAS dpf TCBPA MSC BMI CB MSG EHDPHP Obesogen NASH PFOA DINCH TF TG ETC ROSI PAH NHANES TCEP TR PFOS FFA Cd PAS MEHP EDC ADI DBUP dl non-dl MDC ncRNAs PFAS EFSA NNS DBP DiBP VLDL DBT mtROS Adipocyte differentiation SHS EH-TBB KYN TASH HCB IATA T2D TBT HCH TDCPP BADGE.2H0 ER PCB GIP SSRI BPA BCEP DPHP BPB CAR BPE MECPP ROS BPF MEP PCDD/F FA VT BDCPP CRP TCP FXR TBPH NAFLD BPS DDE NR 3-BHA DDD hMSC WAT Weight gain RXR EGFR HFCS BaP DiDP HDL DDT LDL NPY PBDE PFDA PM2.5 TDI HBCDD GD GI PFBS EGF PFHxS DMP IGF AhR GR BPAF DEP SIRTs POMC DES BAT SCD EPA FAS PM10 PVC PM
ISSN:	0006-2952, 1873-2968, 1356-1839, 1873-2968
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Summary:	Reducing exposure to obesogens is a strategy for preventing obesity. [Display omitted] •There is an expanding global obesity pandemic.•Ubiquitous environmental chemicals called obesogens play a vital role in the obesity pandemic.•Exposure to obesogens occurs throughout the life course from before conception until death.•Development is the most sensitive time for obesogens to impact future weight gain across the lifespan and generations.•Obesogens can act via epigenetic mechanisms.•There is a need to expand understanding of the obesogen paradigm to clinicians and consumers. Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0006-2952 1873-2968 1356-1839 1873-2968
DOI:	10.1016/j.bcp.2022.115015