Altered Expression of Phox2 Transcription Factors in the Locus Coeruleus in Major Depressive Disorder Mimicked by Chronic Stress and Corticosterone Treatment In Vivo and In Vitro

[Display omitted] •Protein levels of Phox2a, mRNA and protein levels of Phox2b were elevated in the locus coeruleus from brain donors of MDD.•CSD significantly increased Phox2a and Phox2b expression in the rat locus coeruleus.•Corticosterone administration increased Phox2b protein levels in the rat...

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Bibliographic Details
Published in:	Neuroscience Vol. 393; pp. 123 - 137
Main Authors:	Fan, Yan, Chen, Ping, Raza, Muhammad U., Szebeni, Attila, Szebeni, Katalin, Ordway, Gregory A., Stockmeier, Craig A., Zhu, Meng-Yang
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 21.11.2018
Subjects:	Animals corticosterone Corticosterone - metabolism Corticosterone - pharmacology Depressive Disorder, Major - metabolism Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Homeodomain Proteins - metabolism locus coeruleus Locus Coeruleus - drug effects Locus Coeruleus - metabolism major depressive disorder Male Nerve Tissue Proteins - metabolism Norepinephrine - metabolism Phox2 genes postmortem Rats, Inbred F344 RNA, Messenger - metabolism stress Transcription Factors - metabolism PBS stress ir DBH MDD q-PCR locus coeruleus CORT TH major depressive disorder CSD postmortem LC Phox2 genes corticosterone
ISSN:	0306-4522, 1873-7544, 1873-7544
Online Access:	Get full text
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