Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids

Heterosis refers to the superior performance of hybrid progeny relative to their inbred parents, but the mechanisms responsible are unknown. Hybrids between the maize inbred lines B73 and Mo17 exhibit heterosis regardless of cross direction. These reciprocal hybrids differ from each other phenotypic...

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Published in:	Science (American Association for the Advancement of Science) Vol. 326; no. 5956; p. 1118
Main Authors:	Swanson-Wagner, Ruth A, DeCook, Rhonda, Jia, Yi, Bancroft, Tim, Ji, Tieming, Zhao, Xuefeng, Nettleton, Dan, Schnable, Patrick S
Format:	Journal Article
Language:	English
Published:	United States 20.11.2009
Subjects:	Chromosome Mapping Crosses, Genetic Gene Expression Profiling Gene Expression Regulation, Plant Genes, Plant Genome, Plant Genomic Imprinting Hybrid Vigor Hybridization, Genetic Inbreeding Oligonucleotide Array Sequence Analysis Phenotype Quantitative Trait Loci Zea mays - genetics Zea mays - physiology
ISSN:	1095-9203, 1095-9203
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Abstract	Heterosis refers to the superior performance of hybrid progeny relative to their inbred parents, but the mechanisms responsible are unknown. Hybrids between the maize inbred lines B73 and Mo17 exhibit heterosis regardless of cross direction. These reciprocal hybrids differ from each other phenotypically, and 30 to 50% of their genes are differentially expressed. We identified approximately 4000 expression quantitative trait loci (eQTL) that allowed us to identify markers linked to variation in expression. We found that over three-quarters of these eQTL act in trans (78%) and that 86% of these differentially regulate transcript accumulation in a manner consistent with gene expression in the hybrid being regulated exclusively by the paternally transmitted allele. This result suggests that widespread imprinting contributes to the regulation of gene expression in maize hybrids.
AbstractList	Heterosis refers to the superior performance of hybrid progeny relative to their inbred parents, but the mechanisms responsible are unknown. Hybrids between the maize inbred lines B73 and Mo17 exhibit heterosis regardless of cross direction. These reciprocal hybrids differ from each other phenotypically, and 30 to 50% of their genes are differentially expressed. We identified approximately 4000 expression quantitative trait loci (eQTL) that allowed us to identify markers linked to variation in expression. We found that over three-quarters of these eQTL act in trans (78%) and that 86% of these differentially regulate transcript accumulation in a manner consistent with gene expression in the hybrid being regulated exclusively by the paternally transmitted allele. This result suggests that widespread imprinting contributes to the regulation of gene expression in maize hybrids.Heterosis refers to the superior performance of hybrid progeny relative to their inbred parents, but the mechanisms responsible are unknown. Hybrids between the maize inbred lines B73 and Mo17 exhibit heterosis regardless of cross direction. These reciprocal hybrids differ from each other phenotypically, and 30 to 50% of their genes are differentially expressed. We identified approximately 4000 expression quantitative trait loci (eQTL) that allowed us to identify markers linked to variation in expression. We found that over three-quarters of these eQTL act in trans (78%) and that 86% of these differentially regulate transcript accumulation in a manner consistent with gene expression in the hybrid being regulated exclusively by the paternally transmitted allele. This result suggests that widespread imprinting contributes to the regulation of gene expression in maize hybrids. Heterosis refers to the superior performance of hybrid progeny relative to their inbred parents, but the mechanisms responsible are unknown. Hybrids between the maize inbred lines B73 and Mo17 exhibit heterosis regardless of cross direction. These reciprocal hybrids differ from each other phenotypically, and 30 to 50% of their genes are differentially expressed. We identified approximately 4000 expression quantitative trait loci (eQTL) that allowed us to identify markers linked to variation in expression. We found that over three-quarters of these eQTL act in trans (78%) and that 86% of these differentially regulate transcript accumulation in a manner consistent with gene expression in the hybrid being regulated exclusively by the paternally transmitted allele. This result suggests that widespread imprinting contributes to the regulation of gene expression in maize hybrids.
Author	Jia, Yi Schnable, Patrick S Swanson-Wagner, Ruth A DeCook, Rhonda Nettleton, Dan Ji, Tieming Bancroft, Tim Zhao, Xuefeng
Author_xml	– sequence: 1 givenname: Ruth A surname: Swanson-Wagner fullname: Swanson-Wagner, Ruth A organization: Iowa State University, Ames, IA 50011, USA – sequence: 2 givenname: Rhonda surname: DeCook fullname: DeCook, Rhonda – sequence: 3 givenname: Yi surname: Jia fullname: Jia, Yi – sequence: 4 givenname: Tim surname: Bancroft fullname: Bancroft, Tim – sequence: 5 givenname: Tieming surname: Ji fullname: Ji, Tieming – sequence: 6 givenname: Xuefeng surname: Zhao fullname: Zhao, Xuefeng – sequence: 7 givenname: Dan surname: Nettleton fullname: Nettleton, Dan – sequence: 8 givenname: Patrick S surname: Schnable fullname: Schnable, Patrick S
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SubjectTerms	Chromosome Mapping Crosses, Genetic Gene Expression Profiling Gene Expression Regulation, Plant Genes, Plant Genome, Plant Genomic Imprinting Hybrid Vigor Hybridization, Genetic Inbreeding Oligonucleotide Array Sequence Analysis Phenotype Quantitative Trait Loci Zea mays - genetics Zea mays - physiology
Title	Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids
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