Macrophages in Atherosclerosis Regression

Macrophages play a central role in the development of atherosclerotic cardiovascular disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease, cerebrovascular disease, and aortic atherosclerosis. In each vascular bed, macrophages contribute to the maintenance of the loca...

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Bibliographic Details
Published in:Arteriosclerosis, thrombosis, and vascular biology Vol. 40; no. 1; p. 20
Main Author: Barrett, Tessa J
Format: Journal Article
Language:English
Published: United States 01.01.2020
Subjects:
Animals
Atherosclerosis - immunology
Atherosclerosis - metabolism
Atherosclerosis - pathology
Coronary Artery Disease - immunology
Coronary Artery Disease - metabolism
Coronary Artery Disease - pathology
Disease Progression
Humans
Leukocyte Count
Macrophage Activation
Macrophages - metabolism
Macrophages - microbiology
Macrophages - pathology
Phenotype
Plaque, Atherosclerotic - immunology
Plaque, Atherosclerotic - metabolism
Plaque, Atherosclerotic - pathology
atherosclerosis
coronary artery disease
macrophages
thrombosis
inflammation
ISSN:1524-4636, 1524-4636
Online Access:Get more information
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Summary:Macrophages play a central role in the development of atherosclerotic cardiovascular disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease, cerebrovascular disease, and aortic atherosclerosis. In each vascular bed, macrophages contribute to the maintenance of the local inflammatory response, propagate plaque development, and promote thrombosis. These central roles, coupled with their plasticity, makes macrophages attractive therapeutic targets in stemming the development of and stabilizing existing atherosclerosis. In the context of ASCVD, classically activated M1 macrophages initiate and sustain inflammation, and alternatively activated M2 macrophages resolve inflammation. However, this classification is now considered an oversimplification, and a greater understanding of plaque macrophage physiology in ASCVD is required to aid in the development of therapeutics to promote ASCVD regression. Reviewed herein are the macrophage phenotypes and molecular regulators characteristic of ASCVD regression, and the current murine models of ASCVD regression.
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ISSN:1524-4636
1524-4636
DOI:10.1161/ATVBAHA.119.312802