Cytokines as biomarkers of Crimean-Congo hemorrhagic fever
Crimean‐Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the course and outcome of the disease depend on the viral load and the balance among the immune response mediators, and that a fatal outcome is the...
Saved in:
| Published in: | Journal of medical virology Vol. 88; no. 1; pp. 21 - 27 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Blackwell Publishing Ltd
01.01.2016
Wiley Subscription Services, Inc |
| Subjects: | |
| ISSN: | 0146-6615, 1096-9071 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Crimean‐Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the course and outcome of the disease depend on the viral load and the balance among the immune response mediators, and that a fatal outcome is the result of a “cytokine storm.” The level of 27 cytokines was measured in serum samples taken from 29 patients during the acute phase of the disease. Two cases were fatal. Among survivors, significant differences between severe and non‐severe cases were observed in the levels of IP‐10, and MCP‐1, while the levels of IL‐1b, IL‐5, IL‐6, IL‐8, IL‐9, IL‐10, IL‐15, IP‐10, MCP‐1, TNF‐α, and RANTES differed significantly between fatal and non‐fatal cases (P < 0.05). RANTES was negatively correlated with the outcome of the disease. A striking similarity with the cytokine patterns seen in Ebola virus disease was observed. A weak Th1 immune response was seen. The viral load was positively correlated with IL‐10, IP‐10, and MCP‐1 levels, and negatively correlated with the ratio IL‐12/IL‐10. Especially IP‐10 and MCP‐1 were significantly associated with the viral load, the severity and outcome of the disease, and they could act as biomarkers and, probably, as potential targets for treatment strategies design. J. Med. Virol. 88:21–27, 2016. © 2015 Wiley Periodicals, Inc. |
|---|---|
| AbstractList | Crimean-Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the course and outcome of the disease depend on the viral load and the balance among the immune response mediators, and that a fatal outcome is the result of a "cytokine storm." The level of 27 cytokines was measured in serum samples taken from 29 patients during the acute phase of the disease. Two cases were fatal. Among survivors, significant differences between severe and non-severe cases were observed in the levels of IP-10, and MCP-1, while the levels of IL-1b, IL-5, IL-6, IL-8, IL-9, IL-10, IL-15, IP-10, MCP-1, TNF-α, and RANTES differed significantly between fatal and non-fatal cases (P < 0.05). RANTES was negatively correlated with the outcome of the disease. A striking similarity with the cytokine patterns seen in Ebola virus disease was observed. A weak Th1 immune response was seen. The viral load was positively correlated with IL-10, IP-10, and MCP-1 levels, and negatively correlated with the ratio IL-12/IL-10. Especially IP-10 and MCP-1 were significantly associated with the viral load, the severity and outcome of the disease, and they could act as biomarkers and, probably, as potential targets for treatment strategies design. Crimean‐Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the course and outcome of the disease depend on the viral load and the balance among the immune response mediators, and that a fatal outcome is the result of a “cytokine storm.” The level of 27 cytokines was measured in serum samples taken from 29 patients during the acute phase of the disease. Two cases were fatal. Among survivors, significant differences between severe and non‐severe cases were observed in the levels of IP‐10, and MCP‐1, while the levels of IL‐1b, IL‐5, IL‐6, IL‐8, IL‐9, IL‐10, IL‐15, IP‐10, MCP‐1, TNF‐α, and RANTES differed significantly between fatal and non‐fatal cases (P < 0.05). RANTES was negatively correlated with the outcome of the disease. A striking similarity with the cytokine patterns seen in Ebola virus disease was observed. A weak Th1 immune response was seen. The viral load was positively correlated with IL‐10, IP‐10, and MCP‐1 levels, and negatively correlated with the ratio IL‐12/IL‐10. Especially IP‐10 and MCP‐1 were significantly associated with the viral load, the severity and outcome of the disease, and they could act as biomarkers and, probably, as potential targets for treatment strategies design. J. Med. Virol. 88:21–27, 2016. © 2015 Wiley Periodicals, Inc. Crimean-Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the course and outcome of the disease depend on the viral load and the balance among the immune response mediators, and that a fatal outcome is the result of a "cytokine storm." The level of 27 cytokines was measured in serum samples taken from 29 patients during the acute phase of the disease. Two cases were fatal. Among survivors, significant differences between severe and non-severe cases were observed in the levels of IP-10, and MCP-1, while the levels of IL-1b, IL-5, IL-6, IL-8, IL-9, IL-10, IL-15, IP-10, MCP-1, TNF- alpha , and RANTES differed significantly between fatal and non-fatal cases (P<0.05). RANTES was negatively correlated with the outcome of the disease. A striking similarity with the cytokine patterns seen in Ebola virus disease was observed. A weak Th1 immune response was seen. The viral load was positively correlated with IL-10, IP-10, and MCP-1 levels, and negatively correlated with the ratio IL-12/IL-10. Especially IP-10 and MCP-1 were significantly associated with the viral load, the severity and outcome of the disease, and they could act as biomarkers and, probably, as potential targets for treatment strategies design. J. Med. Virol. 88:21-27, 2016. Crimean-Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the course and outcome of the disease depend on the viral load and the balance among the immune response mediators, and that a fatal outcome is the result of a "cytokine storm." The level of 27 cytokines was measured in serum samples taken from 29 patients during the acute phase of the disease. Two cases were fatal. Among survivors, significant differences between severe and non-severe cases were observed in the levels of IP-10, and MCP-1, while the levels of IL-1b, IL-5, IL-6, IL-8, IL-9, IL-10, IL-15, IP-10, MCP-1, TNF-[alpha], and RANTES differed significantly between fatal and non-fatal cases (P<0.05). RANTES was negatively correlated with the outcome of the disease. A striking similarity with the cytokine patterns seen in Ebola virus disease was observed. A weak Th1 immune response was seen. The viral load was positively correlated with IL-10, IP-10, and MCP-1 levels, and negatively correlated with the ratio IL-12/IL-10. Especially IP-10 and MCP-1 were significantly associated with the viral load, the severity and outcome of the disease, and they could act as biomarkers and, probably, as potential targets for treatment strategies design. J. Med. Virol. 88:21-27, 2016. © 2015 Wiley Periodicals, Inc. |
| Author | Uyar, Yavuz Korukluoglu, Gulay Tsergouli, Katerina Bino, Silvia Çağlayık, Dilek Yağcı Papa, Anna Como, Najada |
| Author_xml | – sequence: 1 givenname: Anna surname: Papa fullname: Papa, Anna email: Correspondence to: Prof. Anna Papa, MD, PhD, Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece., annap@med.auth.gr organization: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece – sequence: 2 givenname: Katerina surname: Tsergouli fullname: Tsergouli, Katerina organization: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece – sequence: 3 givenname: Dilek Yağcı surname: Çağlayık fullname: Çağlayık, Dilek Yağcı organization: Department of Microbiology Reference Laboratories, Virology Reference and Research Laboratory, Public Health Institutions of Turkey, Ankara, Turkey – sequence: 4 givenname: Silvia surname: Bino fullname: Bino, Silvia organization: Institute of Public Health, Tirana, Albania – sequence: 5 givenname: Najada surname: Como fullname: Como, Najada organization: Clinic of Infectious Diseases, Mother Theresa University Hospital, Tirana, Albania – sequence: 6 givenname: Yavuz surname: Uyar fullname: Uyar, Yavuz organization: Department of Microbiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey – sequence: 7 givenname: Gulay surname: Korukluoglu fullname: Korukluoglu, Gulay organization: Department of Microbiology Reference Laboratories, Virology Reference and Research Laboratory, Public Health Institutions of Turkey, Ankara, Turkey |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26118413$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkUtP3DAURi0EguGx6B9Akdi0i4AfiR2zQxEMRTwkREvVjWV7bsBDElM7Qzv_vi4z0wVqJVZ3c86ne--3jdZ73wNCHwg-JBjTo2n3ckgLRugaGhEseS6xIOtohEnBc85JuYW2Y5xijCtJ6SbaopyQqiBshI7r-eCfXA8x0zEzznc6PEGImW-yOrgOdJ_Xvn_w2SN0PoRH_eBs1sALhF200eg2wt5y7qAvZ6d39Xl-eTP-XJ9c5rbkmObGapN2YrycGKNFISeWGNtIIUFbWWqYUMahAm6o5RisBqorC1KbojIMGNtBHxe5z8H_mEEcVOeihbbVPfhZVESwUhJW8PegtOICl1Im9OANOvWz0KdDXilcEiJ4ovaX1Mx0MFHP6SU6zNXqgQk4WgA2-BgDNMq6QQ_O90PQrlUEqz8VqVSReq0oGZ_eGKvQf7HL9J-uhfn_QXVx9XVl5AvDxQF-_TVSqYoLJkp1fz1Wt9-ur4rv4lyN2W9RtK4i |
| CitedBy_id | crossref_primary_10_1016_j_jpeds_2017_08_077 crossref_primary_10_1016_j_cyto_2023_156340 crossref_primary_10_1038_s41564_018_0141_7 crossref_primary_10_1016_j_jcv_2018_01_017 crossref_primary_10_1002_jmv_26877 crossref_primary_10_1002_jmv_25790 crossref_primary_10_1016_j_tmaid_2020_101871 crossref_primary_10_1080_14737159_2019_1615450 crossref_primary_10_1080_22221751_2024_2302103 crossref_primary_10_3390_v16101547 crossref_primary_10_1128_JVI_01662_17 crossref_primary_10_1371_journal_pntd_0008863 crossref_primary_10_1371_journal_ppat_1008183 crossref_primary_10_1038_s41579_023_00871_9 crossref_primary_10_2217_fvl_2023_0008 crossref_primary_10_1371_journal_pone_0157247 crossref_primary_10_1002_jmv_24864 crossref_primary_10_3390_pathogens10070913 crossref_primary_10_1002_jmv_24865 crossref_primary_10_1016_j_antiviral_2017_08_014 crossref_primary_10_1016_j_antiviral_2023_105703 crossref_primary_10_3390_microorganisms9020279 crossref_primary_10_1016_j_antiviral_2022_105244 crossref_primary_10_3201_eid2902_220976 crossref_primary_10_1002_jmv_24990 crossref_primary_10_1016_j_vaccine_2017_05_031 crossref_primary_10_1038_s41598_021_99130_1 crossref_primary_10_1016_j_ymthe_2022_09_016 crossref_primary_10_1016_j_virusres_2018_04_003 crossref_primary_10_1371_journal_ppat_1008050 crossref_primary_10_12688_f1000research_16189_1 crossref_primary_10_31362_patd_399695 crossref_primary_10_1371_journal_ppat_1007430 crossref_primary_10_1016_j_ebiom_2023_104839 crossref_primary_10_1080_22221751_2024_2427782 crossref_primary_10_1007_s00408_016_9913_0 crossref_primary_10_1007_s00705_016_3039_9 crossref_primary_10_1016_j_antiviral_2016_06_011 crossref_primary_10_3390_v11080686 crossref_primary_10_1038_s44298_025_00100_5 crossref_primary_10_1080_20477724_2024_2392225 crossref_primary_10_3389_fcimb_2017_00213 crossref_primary_10_1128_MCB_00542_20 crossref_primary_10_1038_s41541_024_00877_1 crossref_primary_10_7554_eLife_63906 crossref_primary_10_4103_1995_7645_315899 crossref_primary_10_1128_JVI_00554_19 crossref_primary_10_1016_j_ymeth_2019_02_008 crossref_primary_10_3390_diagnostics13162708 crossref_primary_10_3390_v11030287 crossref_primary_10_1371_journal_pntd_0008637 |
| Cites_doi | 10.1093/infdis/jis452 10.1111/j.1469-0691.2009.02996.x 10.1186/1471-2334-14-416 10.3201/eid1305.061588 10.1016/j.biocel.2005.02.018 10.1016/j.coi.2005.05.001 10.1016/j.diagmicrobio.2013.12.015 10.1002/jmv.23875 10.1161/01.ATV.0000096208.80992.63 10.1002/jmv.23666 10.1086/506623 10.1016/j.antiviral.2004.08.001 10.1038/ni0909-929 10.1016/S1473-3099(06)70435-2 10.3201/eid1311.070222 10.1016/j.jcv.2014.08.029 10.1002/jmv.24141 10.1016/S1473-3099(04)01103-X 10.1016/j.jcv.2006.04.007 10.1099/vir.0.82093-0 10.1128/CVI.00530-09 10.1128/CVI.00030-12 10.1055/s-0037-1613397 10.1086/521244 10.1038/nm1142 10.1086/520611 10.1086/500836 10.1371/journal.pntd.0000837 10.1016/j.ijid.2010.02.2240 10.1016/j.ijid.2011.03.007 10.1093/infdis/jiu088 10.4269/ajtmh.1996.55.190 10.1016/j.ijid.2011.06.005 10.1086/315680 |
| ContentType | Journal Article |
| Copyright | 2015 Wiley Periodicals, Inc. 2016 Wiley Periodicals, Inc. |
| Copyright_xml | – notice: 2015 Wiley Periodicals, Inc. – notice: 2016 Wiley Periodicals, Inc. |
| DBID | BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QL 7TK 7U9 8FD C1K FR3 H94 K9. M7N P64 RC3 7X8 7T5 |
| DOI | 10.1002/jmv.24312 |
| DatabaseName | Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Bacteriology Abstracts (Microbiology B) Neurosciences Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic Immunology Abstracts |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Genetics Abstracts Virology and AIDS Abstracts Technology Research Database Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic Immunology Abstracts |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AIDS and Cancer Research Abstracts Genetics Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1096-9071 |
| EndPage | 27 |
| ExternalDocumentID | 3850641271 26118413 10_1002_jmv_24312 JMV24312 ark_67375_WNG_RXNM4Z7H_G |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: European Commission funderid: 260427 |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 3O- 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAMMB AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABOCM ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFFNX AFFPM AFGKR AFRAH AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHMBA AI. AIACR AIDQK AIDYY AIQQE AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBD EBS ECGQY EJD ELTNK EMOBN F00 F01 F04 F5P FEDTE FUBAC G-S G.N GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M65 MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RX1 RYL SAMSI SUPJJ SV3 TEORI TUS UB1 V2E VH1 W8V W99 WBKPD WHG WIB WIH WIJ WIK WJL WNSPC WOHZO WQJ WXI WXSBR WYISQ X7M XG1 XPP XV2 ZGI ZXP ZZTAW ~IA ~KM ~WT AAHHS ACCFJ AEEZP AEQDE AEUQT AFPWT AIWBW AJBDE RGB RWI WRC WUP AAYXX CITATION O8X CGR CUY CVF ECM EIF NPM 7QL 7TK 7U9 8FD C1K FR3 H94 K9. M7N P64 RC3 7X8 7T5 |
| ID | FETCH-LOGICAL-c5602-bcab096365dbba749dc1bcf979eac95aed236e8e6b2c60ecae2a8ce9ab48b3e33 |
| IEDL.DBID | DRFUL |
| ISICitedReferencesCount | 61 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000363894900003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0146-6615 |
| IngestDate | Sun Nov 09 13:36:46 EST 2025 Thu Oct 02 12:01:22 EDT 2025 Tue Oct 07 05:33:38 EDT 2025 Mon Jul 21 06:08:30 EDT 2025 Sat Nov 29 03:40:31 EST 2025 Tue Nov 18 22:38:37 EST 2025 Wed Jan 22 16:46:53 EST 2025 Sun Sep 21 06:23:49 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | cytokines chemokines biomarkers Crimean-Congo hemorrhagic fever |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor 2015 Wiley Periodicals, Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5602-bcab096365dbba749dc1bcf979eac95aed236e8e6b2c60ecae2a8ce9ab48b3e33 |
| Notes | ark:/67375/WNG-RXNM4Z7H-G ArticleID:JMV24312 istex:8B76D3DED52B701017533EF3E7CBD7B1F99AC261 European Commission - No. 260427 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 26118413 |
| PQID | 1728051176 |
| PQPubID | 105515 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_1735913463 proquest_miscellaneous_1728670599 proquest_journals_1728051176 pubmed_primary_26118413 crossref_citationtrail_10_1002_jmv_24312 crossref_primary_10_1002_jmv_24312 wiley_primary_10_1002_jmv_24312_JMV24312 istex_primary_ark_67375_WNG_RXNM4Z7H_G |
| PublicationCentury | 2000 |
| PublicationDate | January 2016 |
| PublicationDateYYYYMMDD | 2016-01-01 |
| PublicationDate_xml | – month: 01 year: 2016 text: January 2016 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: London |
| PublicationTitle | Journal of medical virology |
| PublicationTitleAlternate | J. Med. Virol |
| PublicationYear | 2016 |
| Publisher | Blackwell Publishing Ltd Wiley Subscription Services, Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Wiley Subscription Services, Inc |
| References | Kaya S, Elaldi N, Kubar A, Gursoy N, Yilmaz M, Karakus G, Gunes T, Polat Z, Gozel MG, Engin A, Dokmetas I, Bakir M, Yilmaz N, Sencan M. 2014b. Sequential determination of serum viral titers, virus-specific IgG antibodies, and TNF-alpha, IL-6, IL-10, and IFN-gamma levels in patients with Crimean-Congo hemorrhagic fever. BMC Infect Dis 14:416. Papa A, Mirazimi A, Koksal I, Estrada-Pena A, Feldmann H. 2015a. Recent advances in research on Crimean-Congo hemorrhagic fever. J Clin Virol. 64:137-143. Ergonul O. 2006. Crimean-Congo haemorrhagic fever. Lancet Infect Dis 6:203-214. Carrol ED, Thomson AP, Mobbs KJ, Hart CA. 2000. The role of RANTES in meningococcal disease. J Infect Dis 182:363-366. McElroy AK, Erickson BR, Flietstra TD, Rollin PE, Nichol ST, Towner JS, Spiropoulou CF. 2014. Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome. J Infect Dis 210:558-566. Reddy V, Mani RS, Desai A, Ravi V. 2014. Correlation of plasma viral loads and presence of Chikungunya IgM antibodies with cytokine/chemokine levels during acute Chikungunya virus infection. J Med Virol 86:1393-1401. Bray M, Geisbert TW. 2005. Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever. Int J Biochem Cell Biol 37:1560-1566. Mahanty S, Bray M. 2004. Pathogenesis of filoviral haemorrhagic fevers. Lancet Infect Dis 4:487-498. Papa A, Bino S, Velo E, Harxhi A, Kota M, Antoniadis A. 2006. Cytokine levels in Crimean-Congo hemorrhagic fever. J Clin Virol 36:272-276. Schnittler HJ, Feldmann H. 2003. Viral hemorrhagic fever-a vascular disease? Thromb Haemost 89:967-972. O'Garra A, Murphy KM. 2009. From IL-10 to IL-12: How pathogens and their products stimulate APCs to induce T(H) 1 development. Nat Immunol 10:929-932. Ozturk B, Tutuncu E, Kuscu F, Gurbuz Y, Sencan I, Tuzun H. 2010. Evaluation of factors predictive of the prognosis in Crimean-Congo hemorrhagic fever: New suggestions. Int J Infect Dis 16:e89-e93. Saksida A, Duh D, Wraber B, Dedushaj I, Ahmeti S, Avsic-Zupanc T. 2010. Interacting roles of immune mechanisms and viral load in the pathogenesis of crimean-congo hemorrhagic fever. Clin Vaccine Immunol 17:1086-1093. Bakir M, Bakir S, Sari I, Celik VK, Gozel MG, Engin A. 2013. Evaluation of the relationship between serum levels of VEGF and sVEGFR1 with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. J Med Virol 85:1794-1801. Bray M. 2005. Pathogenesis of viral hemorrhagic fever. Curr Opin Immunol 17:399-403. Hutchinson KL, Rollin PE. 2007. Cytokine and chemokine expression in humans infected with Sudan Ebola virus. J Infect Dis S357-S363. Papa A, Drosten C, Bino S, Papadimitriou E, Panning M, Velo E, Kota M, Harxhi A, Antoniadis A. 2007. Viral load and Crimean-Congo hemorrhagic fever. Emerg Infect Dis 13:805-806. Kaya A, Engin A, Guven AS, Icagasioglu FD, Cevit O, Elaldi N, Gulturk A. 2014a. Crimean-Congo hemorrhagic fever disease due to tick bite with very long incubation periods. Int J Infect Dis 15:e449-e452. Rollins BJ, Yoshimura T, Leonard EJ, Pober JS. 1990. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am J Pathol 136:1229-1233. Sun Y, Jin C, Zhan F, Wang X, Liang M, Zhang Q, Ding S, Guan X, Huo X, Li C, Qu J, Wang Q, Zhang S, Zhang Y, Wang S, Xu A, Bi Z, Li D. 2012. Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome. J Infect Dis 206:1085-1094. Yamada M, Kim S, Egashira K, Takeya M, Ikeda T, Mimura O, Iwao H. 2003. Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 23:1996-2001. Ergonul O, Tuncbilek S, Baykam N, Celikbas A, Dokuzoguz B. 2006. Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic fever. J Infect Dis 193:941-944. Whitehouse CA. 2004. Crimean-Congo hemorrhagic fever. Antiviral Res 64:145-160. John CC, Opika-Opoka R, Byarugaba J, Idro R, Boivin MJ. 2006. Low levels of RANTES are associated with mortality in children with cerebral malaria. J Infect Dis 194:837-845. Duh D, Saksida A, Petrovec M, Ahmeti S, Dedushaj I, Panning M, Drosten C, Avsic-Zupanc T. 2007. Viral load as predictor of Crimean-Congo hemorrhagic fever outcome. Emerg Infect Dis 13:1769-1772. Geisbert TW, Jahrling PB. 2004. Exotic emerging viral diseases: Progress and challenges. Nat Med 10:S110-S121. Cevik MA, Erbay A, Bodur H, Eren SS, Akinci E, Sener K, Onguru P, Kubar A. 2007. Viral load as a predictor of outcome in Crimean-Congo hemorrhagic fever. Clin Infect Dis 45:e96-100. Papa A, Dalla V, Papadimitriou E, Kartalis GN, Antoniadis A. 2009. Emergence of Crimean-Congo haemorrhagic fever in Greece. Clin Microbiol Infect 16:843-847. Papa A, Yagci Caglayık D, Christova I, Tsergouli K, Korukluoglu G, Uyar Y. 2015b. Crimean-Congo hemorrhagic fever: CXCL10 correlates with the viral load. J Med Virol 87:899-903. Ergunay K, Kocak Tufan Z, Bulut C, Kinikli S, Demiroz AP, Ozkul A. 2014. Antibody responses and viral load in patients with Crimean-Congo hemorrhagic fever: A comprehensive analysis during the early stages of the infection. Diagn Microbiol Infect Dis 79:31-36. Lee YR, Liu MT, Lei HY, Liu CC, Wu JM, Tung YC, Lin YS, Yeh TM, Chen SH, Liu HS. 2006. MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells. J Gen Virol 87:3623-3630. Wauquier N, Becquart P, Padilla C, Baize S, Leroy EM. 2010. Human fatal Zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis. PLoS Negl Trop Dis 4:e837. Bodur H, Akinci E, Onguru P, Uyar Y, Basturk B, Gozel MG, Kayaaslan BU. 2010. Evidence of vascular endothelial damage in Crimean-Congo hemorrhagic fever. Int J Infect Dis 14:e704-e707. Watson DC, Sargianou M, Panos G. 2012. Interleukin-12 (IL-12)/IL-10 ratio as a marker of disease severity in Crimean-Congo hemorrhagic fever. Clin Vaccine Immunol 19:823-824. Schwarz TF, Nsanze H, Longson M, Nitschko H, Gilch S, Shurie H, Ameen A, Zahir AR, Acharya UG, Jager G. 1996. Polymerase chain reaction for diagnosis and identification of distinct variants of Crimean-Congo hemorrhagic fever virus in the United Arab Emirates. Am J Trop Med Hyg 55:190-196. 2004; 64 2010; 16 2010; 14 2015a; 64 2010 2010; 17 2006; 36 2013; 85 2004; 4 2007 2006; 6 2012; 19 2006; 194 2006; 193 2014; 210 2007; 13 2014a; 15 2015b; 87 2012; 206 2014; 86 1996; 55 2004; 10 2009; 10 1990; 136 2014b; 14 2006; 87 2000; 182 2014; 79 2005; 37 2005; 17 2007; 45 2010; 4 2009; 16 2003; 89 2003; 23 e_1_2_6_32_1 e_1_2_6_10_1 e_1_2_6_30_1 Rollins BJ (e_1_2_6_29_1) 1990; 136 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_14_1 e_1_2_6_35_1 e_1_2_6_11_1 e_1_2_6_34_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_16_1 e_1_2_6_37_1 Schnittler HJ (e_1_2_6_31_1) 2003; 89 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 Papa A (e_1_2_6_22_1) 2010 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1 |
| References_xml | – reference: Bray M, Geisbert TW. 2005. Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever. Int J Biochem Cell Biol 37:1560-1566. – reference: Cevik MA, Erbay A, Bodur H, Eren SS, Akinci E, Sener K, Onguru P, Kubar A. 2007. Viral load as a predictor of outcome in Crimean-Congo hemorrhagic fever. Clin Infect Dis 45:e96-100. – reference: Papa A, Yagci Caglayık D, Christova I, Tsergouli K, Korukluoglu G, Uyar Y. 2015b. Crimean-Congo hemorrhagic fever: CXCL10 correlates with the viral load. J Med Virol 87:899-903. – reference: Lee YR, Liu MT, Lei HY, Liu CC, Wu JM, Tung YC, Lin YS, Yeh TM, Chen SH, Liu HS. 2006. MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells. J Gen Virol 87:3623-3630. – reference: Kaya A, Engin A, Guven AS, Icagasioglu FD, Cevit O, Elaldi N, Gulturk A. 2014a. Crimean-Congo hemorrhagic fever disease due to tick bite with very long incubation periods. Int J Infect Dis 15:e449-e452. – reference: Ergonul O, Tuncbilek S, Baykam N, Celikbas A, Dokuzoguz B. 2006. Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic fever. J Infect Dis 193:941-944. – reference: Ergunay K, Kocak Tufan Z, Bulut C, Kinikli S, Demiroz AP, Ozkul A. 2014. Antibody responses and viral load in patients with Crimean-Congo hemorrhagic fever: A comprehensive analysis during the early stages of the infection. Diagn Microbiol Infect Dis 79:31-36. – reference: Papa A, Bino S, Velo E, Harxhi A, Kota M, Antoniadis A. 2006. Cytokine levels in Crimean-Congo hemorrhagic fever. J Clin Virol 36:272-276. – reference: John CC, Opika-Opoka R, Byarugaba J, Idro R, Boivin MJ. 2006. Low levels of RANTES are associated with mortality in children with cerebral malaria. J Infect Dis 194:837-845. – reference: Mahanty S, Bray M. 2004. Pathogenesis of filoviral haemorrhagic fevers. Lancet Infect Dis 4:487-498. – reference: Schwarz TF, Nsanze H, Longson M, Nitschko H, Gilch S, Shurie H, Ameen A, Zahir AR, Acharya UG, Jager G. 1996. Polymerase chain reaction for diagnosis and identification of distinct variants of Crimean-Congo hemorrhagic fever virus in the United Arab Emirates. Am J Trop Med Hyg 55:190-196. – reference: Watson DC, Sargianou M, Panos G. 2012. Interleukin-12 (IL-12)/IL-10 ratio as a marker of disease severity in Crimean-Congo hemorrhagic fever. Clin Vaccine Immunol 19:823-824. – reference: Sun Y, Jin C, Zhan F, Wang X, Liang M, Zhang Q, Ding S, Guan X, Huo X, Li C, Qu J, Wang Q, Zhang S, Zhang Y, Wang S, Xu A, Bi Z, Li D. 2012. Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome. J Infect Dis 206:1085-1094. – reference: Duh D, Saksida A, Petrovec M, Ahmeti S, Dedushaj I, Panning M, Drosten C, Avsic-Zupanc T. 2007. Viral load as predictor of Crimean-Congo hemorrhagic fever outcome. Emerg Infect Dis 13:1769-1772. – reference: Ergonul O. 2006. Crimean-Congo haemorrhagic fever. Lancet Infect Dis 6:203-214. – reference: Papa A, Mirazimi A, Koksal I, Estrada-Pena A, Feldmann H. 2015a. Recent advances in research on Crimean-Congo hemorrhagic fever. J Clin Virol. 64:137-143. – reference: Saksida A, Duh D, Wraber B, Dedushaj I, Ahmeti S, Avsic-Zupanc T. 2010. Interacting roles of immune mechanisms and viral load in the pathogenesis of crimean-congo hemorrhagic fever. Clin Vaccine Immunol 17:1086-1093. – reference: Papa A, Drosten C, Bino S, Papadimitriou E, Panning M, Velo E, Kota M, Harxhi A, Antoniadis A. 2007. Viral load and Crimean-Congo hemorrhagic fever. Emerg Infect Dis 13:805-806. – reference: Geisbert TW, Jahrling PB. 2004. Exotic emerging viral diseases: Progress and challenges. Nat Med 10:S110-S121. – reference: Whitehouse CA. 2004. Crimean-Congo hemorrhagic fever. Antiviral Res 64:145-160. – reference: Carrol ED, Thomson AP, Mobbs KJ, Hart CA. 2000. The role of RANTES in meningococcal disease. J Infect Dis 182:363-366. – reference: Kaya S, Elaldi N, Kubar A, Gursoy N, Yilmaz M, Karakus G, Gunes T, Polat Z, Gozel MG, Engin A, Dokmetas I, Bakir M, Yilmaz N, Sencan M. 2014b. Sequential determination of serum viral titers, virus-specific IgG antibodies, and TNF-alpha, IL-6, IL-10, and IFN-gamma levels in patients with Crimean-Congo hemorrhagic fever. BMC Infect Dis 14:416. – reference: Bakir M, Bakir S, Sari I, Celik VK, Gozel MG, Engin A. 2013. Evaluation of the relationship between serum levels of VEGF and sVEGFR1 with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. J Med Virol 85:1794-1801. – reference: Bray M. 2005. Pathogenesis of viral hemorrhagic fever. Curr Opin Immunol 17:399-403. – reference: Wauquier N, Becquart P, Padilla C, Baize S, Leroy EM. 2010. Human fatal Zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis. PLoS Negl Trop Dis 4:e837. – reference: Yamada M, Kim S, Egashira K, Takeya M, Ikeda T, Mimura O, Iwao H. 2003. Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 23:1996-2001. – reference: Papa A, Dalla V, Papadimitriou E, Kartalis GN, Antoniadis A. 2009. Emergence of Crimean-Congo haemorrhagic fever in Greece. Clin Microbiol Infect 16:843-847. – reference: Ozturk B, Tutuncu E, Kuscu F, Gurbuz Y, Sencan I, Tuzun H. 2010. Evaluation of factors predictive of the prognosis in Crimean-Congo hemorrhagic fever: New suggestions. Int J Infect Dis 16:e89-e93. – reference: McElroy AK, Erickson BR, Flietstra TD, Rollin PE, Nichol ST, Towner JS, Spiropoulou CF. 2014. Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome. J Infect Dis 210:558-566. – reference: O'Garra A, Murphy KM. 2009. From IL-10 to IL-12: How pathogens and their products stimulate APCs to induce T(H) 1 development. Nat Immunol 10:929-932. – reference: Reddy V, Mani RS, Desai A, Ravi V. 2014. Correlation of plasma viral loads and presence of Chikungunya IgM antibodies with cytokine/chemokine levels during acute Chikungunya virus infection. J Med Virol 86:1393-1401. – reference: Schnittler HJ, Feldmann H. 2003. Viral hemorrhagic fever-a vascular disease? Thromb Haemost 89:967-972. – reference: Hutchinson KL, Rollin PE. 2007. Cytokine and chemokine expression in humans infected with Sudan Ebola virus. J Infect Dis S357-S363. – reference: Rollins BJ, Yoshimura T, Leonard EJ, Pober JS. 1990. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am J Pathol 136:1229-1233. – reference: Bodur H, Akinci E, Onguru P, Uyar Y, Basturk B, Gozel MG, Kayaaslan BU. 2010. Evidence of vascular endothelial damage in Crimean-Congo hemorrhagic fever. Int J Infect Dis 14:e704-e707. – volume: 55 start-page: 190 year: 1996 end-page: 196 article-title: Polymerase chain reaction for diagnosis and identification of distinct variants of Crimean‐Congo hemorrhagic fever virus in the United Arab Emirates publication-title: Am J Trop Med Hyg – volume: 14 start-page: 416 year: 2014b article-title: Sequential determination of serum viral titers, virus‐specific IgG antibodies, and TNF‐alpha, IL‐6, IL‐10, and IFN‐gamma levels in patients with Crimean‐Congo hemorrhagic fever publication-title: BMC Infect Dis – volume: 16 start-page: 843 year: 2009 end-page: 847 article-title: Emergence of Crimean‐Congo haemorrhagic fever in Greece publication-title: Clin Microbiol Infect – volume: 136 start-page: 1229 year: 1990 end-page: 1233 article-title: Cytokine‐activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP‐1/JE publication-title: Am J Pathol – volume: 23 start-page: 1996 year: 2003 end-page: 2001 article-title: Molecular mechanism and role of endothelial monocyte chemoattractant protein‐1 induction by vascular endothelial growth factor publication-title: Arterioscler Thromb Vasc Biol – volume: 64 start-page: 137 year: 2015a end-page: 143 article-title: Recent advances in research on Crimean‐Congo hemorrhagic fever publication-title: J Clin Virol. – volume: 36 start-page: 272 year: 2006 end-page: 276 article-title: Cytokine levels in Crimean‐Congo hemorrhagic fever publication-title: J Clin Virol – volume: 19 start-page: 823 year: 2012 end-page: 824 article-title: Interleukin‐12 (IL‐12)/IL‐10 ratio as a marker of disease severity in Crimean‐Congo hemorrhagic fever publication-title: Clin Vaccine Immunol – volume: 4 start-page: e837 year: 2010 article-title: Human fatal Zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis publication-title: PLoS Negl Trop Dis – volume: 17 start-page: 399 year: 2005 end-page: 403 article-title: Pathogenesis of viral hemorrhagic fever publication-title: Curr Opin Immunol – volume: 15 start-page: e449 year: 2014a end-page: e452 article-title: Crimean‐Congo hemorrhagic fever disease due to tick bite with very long incubation periods publication-title: Int J Infect Dis – volume: 210 start-page: 558 year: 2014 end-page: 566 article-title: Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome publication-title: J Infect Dis – volume: 85 start-page: 1794 year: 2013 end-page: 1801 article-title: Evaluation of the relationship between serum levels of VEGF and sVEGFR1 with mortality and prognosis in patients with Crimean‐Congo hemorrhagic fever publication-title: J Med Virol – volume: 10 start-page: 929 year: 2009 end-page: 932 article-title: From IL‐10 to IL‐12: How pathogens and their products stimulate APCs to induce T(H) 1 development publication-title: Nat Immunol – volume: 206 start-page: 1085 year: 2012 end-page: 1094 article-title: Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome publication-title: J Infect Dis – start-page: S357 year: 2007 end-page: S363 article-title: Cytokine and chemokine expression in humans infected with Sudan Ebola virus publication-title: J Infect Dis – volume: 194 start-page: 837 year: 2006 end-page: 845 article-title: Low levels of RANTES are associated with mortality in children with cerebral malaria publication-title: J Infect Dis – volume: 16 start-page: e89 year: 2010 end-page: e93 article-title: Evaluation of factors predictive of the prognosis in Crimean‐Congo hemorrhagic fever: New suggestions publication-title: Int J Infect Dis – volume: 14 start-page: e704 year: 2010 end-page: e707 article-title: Evidence of vascular endothelial damage in Crimean‐Congo hemorrhagic fever publication-title: Int J Infect Dis – volume: 64 start-page: 145 year: 2004 end-page: 160 article-title: Crimean‐Congo hemorrhagic fever publication-title: Antiviral Res – volume: 89 start-page: 967 year: 2003 end-page: 972 article-title: Viral hemorrhagic fever‐a vascular disease? publication-title: Thromb Haemost – volume: 182 start-page: 363 year: 2000 end-page: 366 article-title: The role of RANTES in meningococcal disease publication-title: J Infect Dis – volume: 87 start-page: 3623 year: 2006 end-page: 3630 article-title: MCP‐1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells publication-title: J Gen Virol – volume: 86 start-page: 1393 year: 2014 end-page: 1401 article-title: Correlation of plasma viral loads and presence of Chikungunya IgM antibodies with cytokine/chemokine levels during acute Chikungunya virus infection publication-title: J Med Virol – volume: 6 start-page: 203 year: 2006 end-page: 214 article-title: Crimean‐Congo haemorrhagic fever publication-title: Lancet Infect Dis – volume: 193 start-page: 941 year: 2006 end-page: 944 article-title: Evaluation of serum levels of interleukin (IL)‐6, IL‐10, and tumor necrosis factor‐alpha in patients with Crimean‐Congo hemorrhagic fever publication-title: J Infect Dis – volume: 13 start-page: 1769 year: 2007 end-page: 1772 article-title: Viral load as predictor of Crimean‐Congo hemorrhagic fever outcome publication-title: Emerg Infect Dis – volume: 87 start-page: 899 year: 2015b end-page: 903 article-title: Crimean‐Congo hemorrhagic fever: CXCL10 correlates with the viral load publication-title: J Med Virol – volume: 79 start-page: 31 year: 2014 end-page: 36 article-title: Antibody responses and viral load in patients with Crimean‐Congo hemorrhagic fever: A comprehensive analysis during the early stages of the infection publication-title: Diagn Microbiol Infect Dis – start-page: 49 year: 2010 end-page: 73 – volume: 37 start-page: 1560 year: 2005 end-page: 1566 article-title: Ebola virus: The role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever publication-title: Int J Biochem Cell Biol – volume: 10 start-page: S110 year: 2004 end-page: S121 article-title: Exotic emerging viral diseases: Progress and challenges publication-title: Nat Med – volume: 17 start-page: 1086 year: 2010 end-page: 1093 article-title: Interacting roles of immune mechanisms and viral load in the pathogenesis of crimean‐congo hemorrhagic fever publication-title: Clin Vaccine Immunol – volume: 4 start-page: 487 year: 2004 end-page: 498 article-title: Pathogenesis of filoviral haemorrhagic fevers publication-title: Lancet Infect Dis – volume: 45 start-page: e96 year: 2007 end-page: 100 article-title: Viral load as a predictor of outcome in Crimean‐Congo hemorrhagic fever publication-title: Clin Infect Dis – volume: 13 start-page: 805 year: 2007 end-page: 806 article-title: Viral load and Crimean‐Congo hemorrhagic fever publication-title: Emerg Infect Dis – ident: e_1_2_6_33_1 doi: 10.1093/infdis/jis452 – ident: e_1_2_6_24_1 doi: 10.1111/j.1469-0691.2009.02996.x – ident: e_1_2_6_16_1 doi: 10.1186/1471-2334-14-416 – ident: e_1_2_6_25_1 doi: 10.3201/eid1305.061588 – ident: e_1_2_6_5_1 doi: 10.1016/j.biocel.2005.02.018 – ident: e_1_2_6_4_1 doi: 10.1016/j.coi.2005.05.001 – ident: e_1_2_6_11_1 doi: 10.1016/j.diagmicrobio.2013.12.015 – ident: e_1_2_6_28_1 doi: 10.1002/jmv.23875 – ident: e_1_2_6_37_1 doi: 10.1161/01.ATV.0000096208.80992.63 – ident: e_1_2_6_2_1 doi: 10.1002/jmv.23666 – ident: e_1_2_6_14_1 doi: 10.1086/506623 – start-page: 49 volume-title: Tropical and emerging infectious diseases year: 2010 ident: e_1_2_6_22_1 – volume: 136 start-page: 1229 year: 1990 ident: e_1_2_6_29_1 article-title: Cytokine‐activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP‐1/JE publication-title: Am J Pathol – ident: e_1_2_6_36_1 doi: 10.1016/j.antiviral.2004.08.001 – ident: e_1_2_6_20_1 doi: 10.1038/ni0909-929 – ident: e_1_2_6_9_1 doi: 10.1016/S1473-3099(06)70435-2 – ident: e_1_2_6_8_1 doi: 10.3201/eid1311.070222 – ident: e_1_2_6_26_1 doi: 10.1016/j.jcv.2014.08.029 – ident: e_1_2_6_27_1 doi: 10.1002/jmv.24141 – ident: e_1_2_6_18_1 doi: 10.1016/S1473-3099(04)01103-X – ident: e_1_2_6_23_1 doi: 10.1016/j.jcv.2006.04.007 – ident: e_1_2_6_17_1 doi: 10.1099/vir.0.82093-0 – ident: e_1_2_6_30_1 doi: 10.1128/CVI.00530-09 – ident: e_1_2_6_34_1 doi: 10.1128/CVI.00030-12 – volume: 89 start-page: 967 year: 2003 ident: e_1_2_6_31_1 article-title: Viral hemorrhagic fever‐a vascular disease? publication-title: Thromb Haemost doi: 10.1055/s-0037-1613397 – ident: e_1_2_6_7_1 doi: 10.1086/521244 – ident: e_1_2_6_12_1 doi: 10.1038/nm1142 – ident: e_1_2_6_13_1 doi: 10.1086/520611 – ident: e_1_2_6_10_1 doi: 10.1086/500836 – ident: e_1_2_6_35_1 doi: 10.1371/journal.pntd.0000837 – ident: e_1_2_6_3_1 doi: 10.1016/j.ijid.2010.02.2240 – ident: e_1_2_6_15_1 doi: 10.1016/j.ijid.2011.03.007 – ident: e_1_2_6_19_1 doi: 10.1093/infdis/jiu088 – ident: e_1_2_6_32_1 doi: 10.4269/ajtmh.1996.55.190 – ident: e_1_2_6_21_1 doi: 10.1016/j.ijid.2011.06.005 – ident: e_1_2_6_6_1 doi: 10.1086/315680 |
| SSID | ssj0008922 |
| Score | 2.394933 |
| Snippet | Crimean‐Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the... Crimean-Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the... |
| SourceID | proquest pubmed crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 21 |
| SubjectTerms | Adolescent Adult Aged Biomarkers Biomarkers - blood chemokines Child Child, Preschool Crimean-Congo hemorrhagic fever Cytokines Cytokines - blood Ebola virus Female Fever Hemorrhagic Fever, Crimean - pathology Hemorrhagic Fever, Crimean - virology Humans Male Middle Aged Viral Load Virology Young Adult |
| Title | Cytokines as biomarkers of Crimean-Congo hemorrhagic fever |
| URI | https://api.istex.fr/ark:/67375/WNG-RXNM4Z7H-G/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmv.24312 https://www.ncbi.nlm.nih.gov/pubmed/26118413 https://www.proquest.com/docview/1728051176 https://www.proquest.com/docview/1728670599 https://www.proquest.com/docview/1735913463 |
| Volume | 88 |
| WOSCitedRecordID | wos000363894900003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library - Journals customDbUrl: eissn: 1096-9071 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0008922 issn: 0146-6615 databaseCode: DRFUL dateStart: 19960101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6VXYS4lDcNlCoghHoJ3Y1jOxZc0MK2Qt0VqmhZcbFsZ0IfkFSbbQU3fgK_kV_COMkGVSoIiVskjyVnPC_bM98APHWOG6aYinLkGCWZcJEvkIxMJlWaWGFsXeF9sCun03Q2U-9W4MWyFqbBh-gu3Lxm1PbaK7ix1dZv0NDjL-fPY3J_ZH_7Mckt70H_9d54f7czxKlqHhHIGETkhvgSWGgQb3WTL7ijvufs18tizYuha-17xjf-a9U3YbUNOcNXjYzcghUsbsO1Sfuofgdejr4tyhOf_h6aKvT1-D5lZ16FZR76rl9oip_ff4zK4lMZHvrE3PmhIXsZ5khqcBf2x2_ej3aitqlC5Ci4iSPrjKVjCxM8s9bIRGVuaF2upCITrLjBLGYCUxQ2dmKAzmBsUoeKNi21DBm7B72iLHANQpFhwszQ8UxSXDOQKmNJ7ukSHCC5_gA2l7zVrkUc940vPusGKznWxA1dcyOAJx3paQOzcRnRs3qDOgrihs9Lk1x_mG7rvdl0knyUO3o7gPXlDupWJStdN-Ki8FKKAB53w6RM_oXEFFieNTRCesiav9Ew7tMVBAvgfiMd3YLoOEon5iGNbNZC8Od_0W8nB_XHg38nfQjXKVxrL4DWobeYn-EjuOrOF0fVfAOuyFm60erALwpNCOg |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFD6a1gl4AcY124CAENpLWBsndiztBXV0HbQRmnapeLFs54RxS1DbTfDGT-A38ks4TtKgSRuaxFskf5ac43OzfS4Az62NNZNMBjnGGEQZt4FLkAx0JmQSGa5NleF9NBJpmkwm8t0SbC9yYer6EO2Fm5OMSl87AXcX0lt_q4Z--nr2MiT7Rwq4ExEbEX93dvYHh6NWEyeyfkUgbRCQHYoXlYW64VY7-Zw96jjSfr_I2Tzvu1bGZ3Dr_5Z9G242Tqf_quaSVVjC4g5cGzfP6ndhu_9jXn52AfC-nvkuI98F7Uxnfpn7ru8X6uL3z1_9svhQ-icuNHd6oklj-jmSINyDw8Hrg_4waNoqBJbcmzAwVhs6uDAeZ8ZoEcnM9ozNpZCkhGWsMQsZxwS5CS3votUY6sSipG1LDEPG7sNyURb4EHyeYcR0z8aZIM-mK2TGotzhIuwiGX8PNhfEVbapOe5aX3xRdbXkUBE1VEUND5610G91oY2LQC-qHWoRRA0XmSZidZzuqv1JOo7ei6Ha9WBjsYWqEcqZqlpxkYMpuAdP22ESJ_dGogssT2sMF65ozb8wLHYBC5x58KBmj3ZBdCClM3OPRjYrLrj8X9Sb8VH1sXZ16BO4PjwYj9RoL327DjfIeWuugzZgeT49xUewYs_mH2fTx40o_AGhGAvw |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5Vu6jiQss7bYGAEOoldDdO7FjqBW3ZFtiNqoqWVS-W7Uza8kiq3W0FN34Cv5FfwjjJBlUqCIlbJH-RnLHn4XjmG4Dn1saaSSaDHGMMoozbwBVIBjoTMokM16aq8D4aiTRNJhO5vwTbi1qYmh-i_eHmNKOy107B8TzLt36zhn78cvkyJP9HBrgbuSYyHejuHAwPR60lTmR9i0DWICA_FC-YhXrhVvvyFX_UdaL9el2weTV2rZzPcOX_pr0Kt5qg039V75LbsITFHVgeN9fqd2F78G1efnIJ8L6e-a4i3yXtTGd-mfuu7xfq4uf3H4OyOCn9U5eaOz3VZDH9HEkR7sHh8PX7wV7QtFUILIU3YWCsNnRwYTzOjNEikpntG5tLIckIy1hjFjKOCXITWt5DqzHUiUVJy5YYhozdh05RFvgQfJ5hxHTfxpmgyKYnZMai3OEi7CE5fw82F8JVtuEcd60vPquaLTlUJA1VScODZy30vCbauA70olqhFkHScJlpIlYf0l11MEnH0bHYU7sebCyWUDVKOVNVKy4KMAX34Gk7TOrk7kh0geVFjeHCkdb8DcNil7DAmQcP6u3RTogOpHRm7tPIZrUL_vwt6u34qHpY-3foE1je3xmq0Zv03TrcpNit-Ru0AZ359AIfwQ17OT-bTR83mvALG5ALaw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cytokines+as+biomarkers+of+Crimean-Congo+hemorrhagic+fever&rft.jtitle=Journal+of+medical+virology&rft.au=Papa%2C+Anna&rft.au=Tsergouli%2C+Katerina&rft.au=%C3%87a%C4%9Flay%C4%B1k%2C+Dilek+Ya%C4%9Fc%C4%B1&rft.au=Bino%2C+Silvia&rft.date=2016-01-01&rft.eissn=1096-9071&rft.volume=88&rft.issue=1&rft.spage=21&rft_id=info:doi/10.1002%2Fjmv.24312&rft_id=info%3Apmid%2F26118413&rft.externalDocID=26118413 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0146-6615&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0146-6615&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0146-6615&client=summon |