The Mitochondria-Targeting Agent MitoQ Improves Muscle Atrophy, Weakness and Oxidative Metabolism in C26 Tumor-Bearing Mice

Cancer cachexia is a debilitating syndrome characterized by skeletal muscle wasting, weakness and fatigue. Several pathogenetic mechanisms can contribute to these muscle derangements. Mitochondrial alterations, altered metabolism and increased oxidative stress are known to promote muscle weakness an...

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Veröffentlicht in:	Frontiers in cell and developmental biology Jg. 10; S. 861622
Hauptverfasser:	Pin, Fabrizio, Huot, Joshua R., Bonetto, Andrea
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media SA 22.03.2022 Frontiers Media S.A
Schlagworte:	AKT protein Antioxidants Atrophy Body weight loss Cachexia Cancer Cell and Developmental Biology Chemotherapy Dehydrogenases Drinking water Enzymatic activity Gene expression Gene regulation Genotype & phenotype Glycolysis Hexokinase Homeostasis Kinases Laboratory animals Low density lipoprotein Low density lipoprotein receptors Medical prognosis Metabolism Metastases Mitochondria MitoQ muscle Musculoskeletal system Oxidative metabolism Oxidative stress Penicillin Phosphorylation Pyruvic acid Skeletal muscle Succinate dehydrogenase TOR protein Tumors Indiana United States > US cancer metabolism MitoQ mitochondria cachexia muscle
ISSN:	2296-634X, 2296-634X
Online-Zugang:	Volltext
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