Platelet miRNAs: differential expression in coronary artery disease and associations with course of left ventricular systolic function
Background MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%). Materials and methods In a first cohort, 62 MiRNAs were measured in platelet...
Uloženo v:
| Vydáno v: | BMC cardiovascular disorders Ročník 23; číslo 1; s. 348 - 11 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
BioMed Central
12.07.2023
BioMed Central Ltd Springer Nature B.V BMC |
| Témata: | |
| ISSN: | 1471-2261, 1471-2261 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Background
MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%).
Materials and methods
In a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vitro platelet activation with CRP.
Results
Platelet miRNAs 103a-3p and 155-5p demonstrated higher expression in patients with CCS then in individuals with MI. Furthermore, multiple miRNAs were significantly higher expressed in matched controls compared to MI patients. 8 miRNAs showed higher expression in patients with improving LVEF% after a 1-year follow-up. In our second cohort, we found higher concentrations of 6 miRNAs in the platelet supernatant of patients with CCS, MI and no CAD after in vitro platelet activation. Most of these miRNAs showed a higher abundance in serum of MI patients as compared to CCS.
Conclusion
Several miRNAs show higher expression in platelets of CCS compared to MI. After in vitro platelet activation, a release of multiple miRNAs out of the thrombocyte was observed. Furthermore, upregulation of serum miRNAs was found in MI patients when compared to CCS patients and individuals without CAD. Hence, platelets could present a source of upregulated circulating miRNAs in MI and additionally affect course of LVEF%. |
|---|---|
| AbstractList | MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%).BACKGROUNDMicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%).In a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vitro platelet activation with CRP.MATERIALS AND METHODSIn a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vitro platelet activation with CRP.Platelet miRNAs 103a-3p and 155-5p demonstrated higher expression in patients with CCS then in individuals with MI. Furthermore, multiple miRNAs were significantly higher expressed in matched controls compared to MI patients. 8 miRNAs showed higher expression in patients with improving LVEF% after a 1-year follow-up. In our second cohort, we found higher concentrations of 6 miRNAs in the platelet supernatant of patients with CCS, MI and no CAD after in vitro platelet activation. Most of these miRNAs showed a higher abundance in serum of MI patients as compared to CCS.RESULTSPlatelet miRNAs 103a-3p and 155-5p demonstrated higher expression in patients with CCS then in individuals with MI. Furthermore, multiple miRNAs were significantly higher expressed in matched controls compared to MI patients. 8 miRNAs showed higher expression in patients with improving LVEF% after a 1-year follow-up. In our second cohort, we found higher concentrations of 6 miRNAs in the platelet supernatant of patients with CCS, MI and no CAD after in vitro platelet activation. Most of these miRNAs showed a higher abundance in serum of MI patients as compared to CCS.Several miRNAs show higher expression in platelets of CCS compared to MI. After in vitro platelet activation, a release of multiple miRNAs out of the thrombocyte was observed. Furthermore, upregulation of serum miRNAs was found in MI patients when compared to CCS patients and individuals without CAD. Hence, platelets could present a source of upregulated circulating miRNAs in MI and additionally affect course of LVEF%.CONCLUSIONSeveral miRNAs show higher expression in platelets of CCS compared to MI. After in vitro platelet activation, a release of multiple miRNAs out of the thrombocyte was observed. Furthermore, upregulation of serum miRNAs was found in MI patients when compared to CCS patients and individuals without CAD. Hence, platelets could present a source of upregulated circulating miRNAs in MI and additionally affect course of LVEF%. Background MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%). Materials and methods In a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vitro platelet activation with CRP. Results Platelet miRNAs 103a-3p and 155-5p demonstrated higher expression in patients with CCS then in individuals with MI. Furthermore, multiple miRNAs were significantly higher expressed in matched controls compared to MI patients. 8 miRNAs showed higher expression in patients with improving LVEF% after a 1-year follow-up. In our second cohort, we found higher concentrations of 6 miRNAs in the platelet supernatant of patients with CCS, MI and no CAD after in vitro platelet activation. Most of these miRNAs showed a higher abundance in serum of MI patients as compared to CCS. Conclusion Several miRNAs show higher expression in platelets of CCS compared to MI. After in vitro platelet activation, a release of multiple miRNAs out of the thrombocyte was observed. Furthermore, upregulation of serum miRNAs was found in MI patients when compared to CCS patients and individuals without CAD. Hence, platelets could present a source of upregulated circulating miRNAs in MI and additionally affect course of LVEF%. Abstract Background MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%). Materials and methods In a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vitro platelet activation with CRP. Results Platelet miRNAs 103a-3p and 155-5p demonstrated higher expression in patients with CCS then in individuals with MI. Furthermore, multiple miRNAs were significantly higher expressed in matched controls compared to MI patients. 8 miRNAs showed higher expression in patients with improving LVEF% after a 1-year follow-up. In our second cohort, we found higher concentrations of 6 miRNAs in the platelet supernatant of patients with CCS, MI and no CAD after in vitro platelet activation. Most of these miRNAs showed a higher abundance in serum of MI patients as compared to CCS. Conclusion Several miRNAs show higher expression in platelets of CCS compared to MI. After in vitro platelet activation, a release of multiple miRNAs out of the thrombocyte was observed. Furthermore, upregulation of serum miRNAs was found in MI patients when compared to CCS patients and individuals without CAD. Hence, platelets could present a source of upregulated circulating miRNAs in MI and additionally affect course of LVEF%. MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%). In a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vitro platelet activation with CRP. Platelet miRNAs 103a-3p and 155-5p demonstrated higher expression in patients with CCS then in individuals with MI. Furthermore, multiple miRNAs were significantly higher expressed in matched controls compared to MI patients. 8 miRNAs showed higher expression in patients with improving LVEF% after a 1-year follow-up. In our second cohort, we found higher concentrations of 6 miRNAs in the platelet supernatant of patients with CCS, MI and no CAD after in vitro platelet activation. Most of these miRNAs showed a higher abundance in serum of MI patients as compared to CCS. Several miRNAs show higher expression in platelets of CCS compared to MI. After in vitro platelet activation, a release of multiple miRNAs out of the thrombocyte was observed. Furthermore, upregulation of serum miRNAs was found in MI patients when compared to CCS patients and individuals without CAD. Hence, platelets could present a source of upregulated circulating miRNAs in MI and additionally affect course of LVEF%. BackgroundMicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%).Materials and methodsIn a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vitro platelet activation with CRP.ResultsPlatelet miRNAs 103a-3p and 155-5p demonstrated higher expression in patients with CCS then in individuals with MI. Furthermore, multiple miRNAs were significantly higher expressed in matched controls compared to MI patients. 8 miRNAs showed higher expression in patients with improving LVEF% after a 1-year follow-up. In our second cohort, we found higher concentrations of 6 miRNAs in the platelet supernatant of patients with CCS, MI and no CAD after in vitro platelet activation. Most of these miRNAs showed a higher abundance in serum of MI patients as compared to CCS.ConclusionSeveral miRNAs show higher expression in platelets of CCS compared to MI. After in vitro platelet activation, a release of multiple miRNAs out of the thrombocyte was observed. Furthermore, upregulation of serum miRNAs was found in MI patients when compared to CCS patients and individuals without CAD. Hence, platelets could present a source of upregulated circulating miRNAs in MI and additionally affect course of LVEF%. MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%). In a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vitro platelet activation with CRP. Platelet miRNAs 103a-3p and 155-5p demonstrated higher expression in patients with CCS then in individuals with MI. Furthermore, multiple miRNAs were significantly higher expressed in matched controls compared to MI patients. 8 miRNAs showed higher expression in patients with improving LVEF% after a 1-year follow-up. In our second cohort, we found higher concentrations of 6 miRNAs in the platelet supernatant of patients with CCS, MI and no CAD after in vitro platelet activation. Most of these miRNAs showed a higher abundance in serum of MI patients as compared to CCS. Several miRNAs show higher expression in platelets of CCS compared to MI. After in vitro platelet activation, a release of multiple miRNAs out of the thrombocyte was observed. Furthermore, upregulation of serum miRNAs was found in MI patients when compared to CCS patients and individuals without CAD. Hence, platelets could present a source of upregulated circulating miRNAs in MI and additionally affect course of LVEF%. Background MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with course of left ventricular ejection fraction (LVEF%). Materials and methods In a first cohort, 62 MiRNAs were measured in platelets of 100 patients suffering from CAD. Expression profiles of individuals with chronic coronary syndrome (CCS) and MI were compared (CCS n = 67, MI n = 33). Also, associations between miRNA profiles and change in left ventricular ejection fraction (LVEF%) were investigated. In a second cohort of patients suffering from CCS (n = 10), MI (n = 11) or no CAD (n = 13), we measured miRNA expression in platelets, platelet supernatant and serum. This was carried out before and after in vitro platelet activation with CRP. Results Platelet miRNAs 103a-3p and 155-5p demonstrated higher expression in patients with CCS then in individuals with MI. Furthermore, multiple miRNAs were significantly higher expressed in matched controls compared to MI patients. 8 miRNAs showed higher expression in patients with improving LVEF% after a 1-year follow-up. In our second cohort, we found higher concentrations of 6 miRNAs in the platelet supernatant of patients with CCS, MI and no CAD after in vitro platelet activation. Most of these miRNAs showed a higher abundance in serum of MI patients as compared to CCS. Conclusion Several miRNAs show higher expression in platelets of CCS compared to MI. After in vitro platelet activation, a release of multiple miRNAs out of the thrombocyte was observed. Furthermore, upregulation of serum miRNAs was found in MI patients when compared to CCS patients and individuals without CAD. Hence, platelets could present a source of upregulated circulating miRNAs in MI and additionally affect course of LVEF%. Keywords: Platelet microRNA, Coronary artery disease, Myocardial infarction, MiRNA 103a-3p, MiRNA 155-5p, Left ventricular ejection fraction |
| ArticleNumber | 348 |
| Audience | Academic |
| Author | Schwab, Matthias Rath, Dominik Geisler, Tobias Schaeffeler, Elke Goldschmied, Andreas Drotleff, Bernhard Winter, Stefan Gawaz, Meinrad |
| Author_xml | – sequence: 1 givenname: Andreas surname: Goldschmied fullname: Goldschmied, Andreas organization: Department of Cardiology, University Hospital Tübingen – sequence: 2 givenname: Bernhard surname: Drotleff fullname: Drotleff, Bernhard organization: European Molecular Biology Laboratory – sequence: 3 givenname: Stefan surname: Winter fullname: Winter, Stefan organization: University of Tübingen, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology – sequence: 4 givenname: Elke surname: Schaeffeler fullname: Schaeffeler, Elke organization: University of Tübingen, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology – sequence: 5 givenname: Matthias surname: Schwab fullname: Schwab, Matthias organization: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tübingen – sequence: 6 givenname: Meinrad surname: Gawaz fullname: Gawaz, Meinrad organization: Department of Cardiology, University Hospital Tübingen – sequence: 7 givenname: Tobias surname: Geisler fullname: Geisler, Tobias email: tobias.geisler@med.uni-tuebingen.de organization: Department of Cardiology, University Hospital Tübingen – sequence: 8 givenname: Dominik surname: Rath fullname: Rath, Dominik organization: Department of Cardiology, University Hospital Tübingen |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37438691$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kstu1DAUhiNURC_wAiyQJTZsUnxJbIcNGlVcKlWAEKwtj3M89ShjD3ZS6Avw3Jx0ytAihLyw5fOd3_qP_-PqIKYIVfWU0VPGtHxZGNeK15SLmgoh8fSgOmKNYjXnkh3cOR9Wx6WsKWVK0-5RdShUI7Ts2FH189NgRxhgJJvw-cOivCJ98B4yxDHYgcCPbYZSQookROJSTtHma2LzCLj1oYAtQGzsiS0luWBHRAv5HsZLpKeMxeTJAH4kVyiZg5sGm0m5LmMagiN-im5ueVw99HYo8OR2P6m-vn3z5ex9ffHx3fnZ4qJ2bduNte-7xlrtHaeCN8wK3THeasuWWvUClGhEw0XX64ZKaMFZS5fgG98zAV5BK06q851un-zabHPYoB2TbDA3FymvDHoLbgCjlg6W0kvunGi8FJ3mctk6Br3qGAWGWq93WttpuYHezf7scE_0fiWGS7NKV4bhb3VtJ1Hhxa1CTt8mKKPZhOJgGGyENBXDtZBaqVZQRJ__ha5xvBFnNVNata3EP91TK4sOQvQJH3azqFmoVnayYY1G6vQfFK4eNsFhxnzA-3sNz-463Vv8HSME-A5wOZWSwe8RRs2cVbPLqsGsmpusmtmS2DUVhOMK8h9L_-n6BcXS7XQ |
| Cites_doi | 10.1161/CIRCRESAHA.110.226357 10.1371/journal.pone.0050746 10.1016/j.recesp.2015.10.012 10.1038/ncomms10521 10.1074/jbc.M116.739839 10.1093/eurheartj/eht296 10.1155/2018/6345284 10.1161/CIRCRESAHA.117.305781 10.1016/j.atherosclerosis.2018.01.020 10.1182/blood-2012-04-416594 10.1002/ejhf.332 10.3389/fphys.2018.01770 10.1186/s12968-016-0244-3 10.1161/CIRCRESAHA.110.218297 10.3892/mmr.2017.7575 10.1161/CIRCRESAHA.109.215566 10.1124/pr.112.005983 10.1093/eurjhf/hft088 10.1016/j.thromres.2017.04.016 10.1093/eurheartj/ehq167 10.1080/09537104.2017.1332366 10.1093/bioinformatics/btr597 10.1016/j.gene.2016.06.059 10.1097/MD.0000000000004418 10.1038/cmi.2011.22 10.1002/iid3.392 10.1093/eurheartj/ehx393 10.1055/s-0035-1570077 10.1002/ejhf.495 10.1038/s41580-018-0045-7 10.1182/blood-2012-10-461798 10.1007/s00395-010-0123-2 10.1038/nrd.2016.246 10.1002/ejhf.244 10.1073/pnas.0610983104 10.1016/j.intimp.2020.107138 10.1016/S0092-8674(04)00045-5 10.1073/pnas.1420955112 10.1186/s11658-019-0187-4 10.1159/000445588 10.1093/cvr/cvx157 10.1093/eurheartj/ehq013 10.1182/blood-2013-03-492801 10.1371/journal.pone.0184256 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2023 2023. The Author(s). COPYRIGHT 2023 BioMed Central Ltd. 2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2023 – notice: 2023. The Author(s). – notice: COPYRIGHT 2023 BioMed Central Ltd. – notice: 2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION NPM 3V. 7QP 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 7X8 5PM DOA |
| DOI | 10.1186/s12872-023-03362-0 |
| DatabaseName | Springer Nature OA Free Journals CrossRef PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection PML(ProQuest Medical Library) ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1471-2261 |
| EndPage | 11 |
| ExternalDocumentID | oai_doaj_org_article_7bceb6f62cc34f639826b5c1ed7910e1 PMC10339596 A756964148 37438691 10_1186_s12872_023_03362_0 |
| Genre | Journal Article |
| GeographicLocations | Germany United States--US Netherlands |
| GeographicLocations_xml | – name: Germany – name: Netherlands – name: United States--US |
| GrantInformation_xml | – fundername: Universitätsklinikum Tübingen (8868) – fundername: ; |
| GroupedDBID | --- 0R~ 23N 2WC 53G 5VS 6J9 6PF 7X7 88E 8FI 8FJ AAFWJ AAJSJ AASML AAWTL ABUWG ACGFO ACGFS ACIHN ACPRK ADBBV ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AHBYD AHMBA AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU CS3 DIK DU5 E3Z EBD EBLON EBS ECGQY EMB EMOBN F5P FYUFA GROUPED_DOAJ GX1 HMCUK HYE IAO IHR INH INR ITC KQ8 M1P M48 M~E O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PUEGO RBZ RNS ROL RPM RSV SMD SOJ SV3 TR2 UKHRP W2D WOQ WOW XSB AAYXX AFFHD CITATION ALIPV NPM 3V. 7QP 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI 7X8 5PM |
| ID | FETCH-LOGICAL-c559t-fd94aa8fc203241a3891258a1b87d3e73434239d8406e5ecaa0bef4fd13ef7e53 |
| IEDL.DBID | RSV |
| ISICitedReferencesCount | 2 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001024344100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1471-2261 |
| IngestDate | Mon Nov 10 04:25:43 EST 2025 Tue Nov 04 02:06:40 EST 2025 Sun Nov 09 11:35:21 EST 2025 Mon Oct 06 18:30:53 EDT 2025 Tue Nov 11 10:21:30 EST 2025 Tue Nov 04 18:45:04 EST 2025 Thu Apr 03 07:04:06 EDT 2025 Sat Nov 29 03:53:49 EST 2025 Sat Sep 06 07:28:36 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Platelet microRNA Myocardial infarction MiRNA 103a-3p Coronary artery disease Left ventricular ejection fraction MiRNA 155-5p |
| Language | English |
| License | 2023. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c559t-fd94aa8fc203241a3891258a1b87d3e73434239d8406e5ecaa0bef4fd13ef7e53 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://link.springer.com/10.1186/s12872-023-03362-0 |
| PMID | 37438691 |
| PQID | 2838755674 |
| PQPubID | 44077 |
| PageCount | 11 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7bceb6f62cc34f639826b5c1ed7910e1 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10339596 proquest_miscellaneous_2836877530 proquest_journals_2838755674 gale_infotracmisc_A756964148 gale_infotracacademiconefile_A756964148 pubmed_primary_37438691 crossref_primary_10_1186_s12872_023_03362_0 springer_journals_10_1186_s12872_023_03362_0 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-07-12 |
| PublicationDateYYYYMMDD | 2023-07-12 |
| PublicationDate_xml | – month: 07 year: 2023 text: 2023-07-12 day: 12 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | BMC cardiovascular disorders |
| PublicationTitleAbbrev | BMC Cardiovasc Disord |
| PublicationTitleAlternate | BMC Cardiovasc Disord |
| PublicationYear | 2023 |
| Publisher | BioMed Central BioMed Central Ltd Springer Nature B.V BMC |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: Springer Nature B.V – name: BMC |
| References | 3362_CR28 E Coskunpinar (3362_CR40) 2016; 591 P Hartmann (3362_CR31) 2016; 7 S Stojkovic (3362_CR10) 2018; 269 O Gidlof (3362_CR15) 2013; 121 R Yao (3362_CR34) 2011; 8 CJ Watson (3362_CR47) 2015; 17 XD Li (3362_CR43) 2017; 12 A Florian (3362_CR26) 2018; 9 L Zhang (3362_CR38) 2019; 24 AJ Tijsen (3362_CR8) 2010; 106 M Tan (3362_CR18) 2016; 38 GK Wang (3362_CR5) 2010; 31 Q Su (3362_CR35) 2018; 2018 A Virtue (3362_CR33) 2017; 292 J Li (3362_CR17) 2017; 154 E van der Pol (3362_CR14) 2012; 64 J Zhang (3362_CR48) 2017; 16 A Zampetaki (3362_CR9) 2010; 107 CR Lindsay (3362_CR12) 2016; 42 B Laffont (3362_CR16) 2013; 122 S Becker (3362_CR27) 2016; 18 DP Bartel (3362_CR1) 2004; 116 R Rupaimoole (3362_CR3) 2017; 16 J Li (3362_CR42) 2021; 9 M Roffi (3362_CR22) 2015; 68 ES Ovchinnikova (3362_CR45) 2016; 18 K Li (3362_CR21) 2021; 90 G Montalescot (3362_CR24) 2013; 34 AR Ambrose (3362_CR19) 2018; 29 H Plé (3362_CR11) 2012; 7 R Marfella (3362_CR46) 2013; 15 3362_CR32 G Ceolotto (3362_CR37) 2017; 113 JM Burkhart (3362_CR25) 2012; 120 B Chen (3362_CR20) 2016; 95 B Meder (3362_CR36) 2011; 106 DJ Stekhoven (3362_CR29) 2011; 28 JX Wang (3362_CR30) 2015; 117 EL Vegter (3362_CR44) 2016; 18 E Londin (3362_CR13) 2015; 112 S Fichtlscherer (3362_CR7) 2010; 107 LFR Gebert (3362_CR2) 2019; 20 B Ibanez (3362_CR23) 2018; 39 Y D’Alessandra (3362_CR6) 2010; 31 JA Ward (3362_CR41) 2013; 2 M Karakas (3362_CR39) 2017; 38 R Malik (3362_CR4) 2017; 9 |
| References_xml | – volume: 107 start-page: 810 issue: 6 year: 2010 ident: 3362_CR9 publication-title: Circul Res doi: 10.1161/CIRCRESAHA.110.226357 – volume: 7 start-page: e50746 issue: 12 year: 2012 ident: 3362_CR11 publication-title: PLoS ONE doi: 10.1371/journal.pone.0050746 – volume: 68 start-page: 1125 issue: 12 year: 2015 ident: 3362_CR22 publication-title: Rev Esp Cardiol (Engl Ed) doi: 10.1016/j.recesp.2015.10.012 – volume: 7 start-page: 10521 year: 2016 ident: 3362_CR31 publication-title: Nat Commun doi: 10.1038/ncomms10521 – volume: 292 start-page: 1267 issue: 4 year: 2017 ident: 3362_CR33 publication-title: J Biol Chem doi: 10.1074/jbc.M116.739839 – volume: 34 start-page: 2949 issue: 38 year: 2013 ident: 3362_CR24 publication-title: Eur Heart J doi: 10.1093/eurheartj/eht296 – volume: 2018 start-page: 6345284 year: 2018 ident: 3362_CR35 publication-title: Dis Markers doi: 10.1155/2018/6345284 – volume: 9 start-page: e1188 issue: 4 year: 2017 ident: 3362_CR4 publication-title: Cureus – volume: 117 start-page: 352 issue: 4 year: 2015 ident: 3362_CR30 publication-title: Circul Res doi: 10.1161/CIRCRESAHA.117.305781 – volume: 269 start-page: 197 year: 2018 ident: 3362_CR10 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2018.01.020 – volume: 120 start-page: e73 issue: 15 year: 2012 ident: 3362_CR25 publication-title: Blood doi: 10.1182/blood-2012-04-416594 – volume: 18 start-page: 414 issue: 4 year: 2016 ident: 3362_CR45 publication-title: Eur J Heart Fail doi: 10.1002/ejhf.332 – ident: 3362_CR28 – volume: 9 start-page: 1770 year: 2018 ident: 3362_CR26 publication-title: Front Physiol doi: 10.3389/fphys.2018.01770 – volume: 18 start-page: 25 issue: 1 year: 2016 ident: 3362_CR27 publication-title: J Cardiovasc Magn Reson doi: 10.1186/s12968-016-0244-3 – volume: 106 start-page: 1035 issue: 6 year: 2010 ident: 3362_CR8 publication-title: Circul Res doi: 10.1161/CIRCRESAHA.110.218297 – volume: 16 start-page: 7766 issue: 5 year: 2017 ident: 3362_CR48 publication-title: Mol Med Rep doi: 10.3892/mmr.2017.7575 – volume: 107 start-page: 677 issue: 5 year: 2010 ident: 3362_CR7 publication-title: Circul Res doi: 10.1161/CIRCRESAHA.109.215566 – volume: 64 start-page: 676 issue: 3 year: 2012 ident: 3362_CR14 publication-title: Pharmacol Rev doi: 10.1124/pr.112.005983 – volume: 15 start-page: 1277 issue: 11 year: 2013 ident: 3362_CR46 publication-title: Eur J Heart Fail doi: 10.1093/eurjhf/hft088 – volume: 154 start-page: 96 year: 2017 ident: 3362_CR17 publication-title: Thromb Res doi: 10.1016/j.thromres.2017.04.016 – volume: 31 start-page: 2765 issue: 22 year: 2010 ident: 3362_CR6 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehq167 – volume: 29 start-page: 446 issue: 5 year: 2018 ident: 3362_CR19 publication-title: Platelets doi: 10.1080/09537104.2017.1332366 – volume: 28 start-page: 112 issue: 1 year: 2011 ident: 3362_CR29 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr597 – volume: 591 start-page: 90 issue: 1 year: 2016 ident: 3362_CR40 publication-title: Gene doi: 10.1016/j.gene.2016.06.059 – volume: 95 start-page: e4418 issue: 33 year: 2016 ident: 3362_CR20 publication-title: Med (Baltim) doi: 10.1097/MD.0000000000004418 – volume: 8 start-page: 486 issue: 6 year: 2011 ident: 3362_CR34 publication-title: Cell Mol Immunol doi: 10.1038/cmi.2011.22 – volume: 2 start-page: 108 issue: 2 year: 2013 ident: 3362_CR41 publication-title: Family Med Med Sci Res – volume: 9 start-page: 288 issue: 1 year: 2021 ident: 3362_CR42 publication-title: Immun Inflamm Dis doi: 10.1002/iid3.392 – volume: 39 start-page: 119 issue: 2 year: 2018 ident: 3362_CR23 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehx393 – volume: 42 start-page: 215 issue: 3 year: 2016 ident: 3362_CR12 publication-title: Semin Thromb Hemost doi: 10.1055/s-0035-1570077 – volume: 18 start-page: 457 issue: 5 year: 2016 ident: 3362_CR44 publication-title: Eur J Heart Fail doi: 10.1002/ejhf.495 – volume: 20 start-page: 21 issue: 1 year: 2019 ident: 3362_CR2 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/s41580-018-0045-7 – volume: 121 start-page: 3908 issue: 19 year: 2013 ident: 3362_CR15 publication-title: Blood doi: 10.1182/blood-2012-10-461798 – volume: 106 start-page: 13 issue: 1 year: 2011 ident: 3362_CR36 publication-title: Basic Res Cardiol doi: 10.1007/s00395-010-0123-2 – volume: 16 start-page: 203 issue: 3 year: 2017 ident: 3362_CR3 publication-title: Nat Rev Drug Discovery doi: 10.1038/nrd.2016.246 – volume: 17 start-page: 405 issue: 4 year: 2015 ident: 3362_CR47 publication-title: Eur J Heart Fail doi: 10.1002/ejhf.244 – ident: 3362_CR32 doi: 10.1073/pnas.0610983104 – volume: 90 start-page: 107138 year: 2021 ident: 3362_CR21 publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2020.107138 – volume: 116 start-page: 281 issue: 2 year: 2004 ident: 3362_CR1 publication-title: Cell doi: 10.1016/S0092-8674(04)00045-5 – volume: 38 start-page: 516 issue: 7 year: 2017 ident: 3362_CR39 publication-title: Eur Heart J – volume: 112 start-page: E1106 issue: 10 year: 2015 ident: 3362_CR13 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1420955112 – volume: 24 start-page: 61 year: 2019 ident: 3362_CR38 publication-title: Cell Mol Biol Lett doi: 10.1186/s11658-019-0187-4 – volume: 38 start-page: 2348 issue: 6 year: 2016 ident: 3362_CR18 publication-title: Cell Physiol Biochem doi: 10.1159/000445588 – volume: 113 start-page: 1627 issue: 13 year: 2017 ident: 3362_CR37 publication-title: Cardiovascular Res doi: 10.1093/cvr/cvx157 – volume: 31 start-page: 659 issue: 6 year: 2010 ident: 3362_CR5 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehq013 – volume: 122 start-page: 253 issue: 2 year: 2013 ident: 3362_CR16 publication-title: Blood doi: 10.1182/blood-2013-03-492801 – volume: 12 start-page: e0184256 issue: 9 year: 2017 ident: 3362_CR43 publication-title: PLoS ONE doi: 10.1371/journal.pone.0184256 |
| SSID | ssj0017809 |
| Score | 2.3309805 |
| Snippet | Background
MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential... MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with... Background MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential... BackgroundMicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential... Abstract Background MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 348 |
| SubjectTerms | Acute coronary syndromes Analysis Angiology Atherosclerosis Blood platelets Blood Transfusion Medicine Cardiac output Cardiac Surgery Cardiology Cardiovascular disease Care and treatment Catheters Coronary artery disease Coronary heart disease Coronary vessels Datasets Diagnosis Flow cytometry Gene expression Gene regulation Genetic aspects Health aspects Heart Heart attacks Heart diseases Hypotheses Hypothesis testing Internal Medicine Left ventricular ejection fraction Mann-Whitney U test Measurement Medicine Medicine & Public Health MicroRNA MicroRNAs miRNA MiRNA 103a-3p MiRNA 155-5p Myocardial infarction Platelet microRNA Platelets Vein & artery diseases Ventricle |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3faxQxEA5SRHyRWn9trRJB8EGX7m6ySda3U1p80KOISt9Ckk3w4NyT22tp_wH_bmey2Wu3Ir74ukkgyczszJeZfCHkJb5gXTnL8tYwACglwB2lGM-R-MTVIlQyHg18-yjnc3V62pxce-oLa8IGeuBh4w6ldd6KICrnGA_gTyEetrUrfSvB0_kIfCDqGcFUyh9IVTTjFRklDnv4C8sqB_-UFwzvCRUTNxTZ-v_8J19zSjcLJm9kTaMzOt4l91IUSWfD7O-TW77bI3c-pTz5A_LrZAkxJIiE_lh8ns_6t3R8CAUMekn9RSp_7eiiow5JDMz6ksbyzkuacjbUdC01V9LrKZ7ZQm8s-6CrQJc-bCiWS8YzRLOmyAqNNMMUnSUOeUi-Hh99ef8hTy8u5A6QxSYPbcONUcHhu-q8NJjErGplSqtky7xkPBIGtoAKha-9M6awPvDQlswH6Wv2iOx0q84_IRTCYRGkK1zTCh64tby0NbeoGgXETCojr0cB6J8DsYaOgEQJPYhLg7h0FJcuMvIOZbTtiaTY8QOoik6qov-lKhl5hRLWaLogRmfSDQSYMJJg6ZmsRSM4AMSMHEx6gsm5afOoIzqZfK8hTgPsVwvJM_Ji24wjsYyt86uz2EcoCQgRFvR4UKntkhjEcko0MEs1UbbJmqct3eJ7JAQvYZeauhEZeTPq5dW8_r6p-_9jU5-Su1W0K5mX1QHZ2azP_DNy251vFv36ebTK33HfO8o priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZgi1AvvCmBgoyExAGi5uHYDhe0Ra04wGpVAerNchwbVlqSkmwR_QP8bma8zi4pggvX2FHszHje_oaQZ9jBOjNVHtc6BwclBXdHypzFCHxiCu4y4UMDn96J2UyenpbzEHDrQ1nlIBO9oK5bgzHyA1CDYFoXXLDXZ99i7BqF2dXQQuMq2UGkMjYhO4dHs_nJJo8gZFIOV2UkP-hBGossBj0VJzneF0pG6sij9v8pm39TTpcLJy9lT71SOr75v9u5RW4Ec5RO1_xzm1yxzR1y_X1IuN8lP-dLMEaBtvTr4mQ27V_RoaMKSIYltT9CHW1DFw01iIaguwvq60QvaEj-UN3UVG_ZoKcY_IXZWD9CW0eX1q0o1l36YKTuKMJLI14xRa2Lr9wjH4-PPrx5G4fWDbEBF2UVu7pkWktnsEE7SzVmQ7NC6rSSos6tyJlHHqzBveS2sEbrpLKOuTrNrRO2yO-TSdM29gGhYFdzJ0xiypozx6qKpVXBKuSxBIwvGZEXAwXV2RqhQ3nPRnK1prcCeitPb5VE5BCJvJmJ6Nr-Qdt9VuGwKlEZCx_lmTE5c2DDgQ9WFSa1tQDryqYReY4solAGAB8YHa4ywIIRTUtNRcFLzsDTjMj-aCacXTMeHrhDBdnRqy1rROTpZhjfxHq4xrbnfg6XAlxN2NDemic3W8rBKJS8hFXKEbeO9jweaRZfPLJ4Cn-pLEoekZcDY2_X9fef-vDf23hEdjN_5EScZvtksurO7WNyzXxfLfruSTiyvwBnTkrX priority: 102 providerName: ProQuest |
| Title | Platelet miRNAs: differential expression in coronary artery disease and associations with course of left ventricular systolic function |
| URI | https://link.springer.com/article/10.1186/s12872-023-03362-0 https://www.ncbi.nlm.nih.gov/pubmed/37438691 https://www.proquest.com/docview/2838755674 https://www.proquest.com/docview/2836877530 https://pubmed.ncbi.nlm.nih.gov/PMC10339596 https://doaj.org/article/7bceb6f62cc34f639826b5c1ed7910e1 |
| Volume | 23 |
| WOSCitedRecordID | wos001024344100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: Open Access: BioMedCentral Open Access Titles customDbUrl: eissn: 1471-2261 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017809 issn: 1471-2261 databaseCode: RBZ dateStart: 20010101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1471-2261 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017809 issn: 1471-2261 databaseCode: DOA dateStart: 20010101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1471-2261 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017809 issn: 1471-2261 databaseCode: M~E dateStart: 20010101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1471-2261 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017809 issn: 1471-2261 databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1471-2261 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017809 issn: 1471-2261 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1471-2261 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017809 issn: 1471-2261 databaseCode: PIMPY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: Springer Journals New Starts & Take-Overs Collection customDbUrl: eissn: 1471-2261 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017809 issn: 1471-2261 databaseCode: RSV dateStart: 20011201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1db9Mw0IINIV74_giMykhIPEC0JHZsh7cObQKJVVWBqTxZjmNDpZKipEPsD_C7uXOTjgx4gJdKrc-qfd_nO58JeYovWGe2ZHFlGAQoKYQ7SjEeY-MTmwufyXA0cPJWTiZqPi-m3aWwtq9271OSQVMHsVZivwVNKrMYbEycMLzrA4H6Lpg7heI4e3eyzR1IlRT99Zg_zhuYoNCp_3d9_ItBulgseSFjGgzR0Y3_28JNcr1zPOl4wym3yCVX3yZXj7vU-h3yY7oEtxOoSL8sZpNx-5L2b6eADlhS972rmK3poqYW-x6Y5oyGitAz2qV5qKkras4J3lI85gVorBShK0-Xzq8pVliGY0fTUGwkjZ2JKdpXnHKXfDg6fP_qddw90hBbCEbWsa8KbozyFp9i56nBvGeWK5OWSlbMScZDj8EKAknhcmeNSUrnua9S5rx0ObtHdupV7R4QCh608NImtqgE97wseVrmvERuSsDNUhF53tNNf9304tAhhlFCb1CrAbU6oFYnETlA0m4hsY92-GHVfNKdWGpZWgd_KjJrGffgrUG0VeY2dZUEP8qlEXmGjKFR2oH61nSXFmDB2DdLj2UuCsEhpozI3gASpNQOh3vW0p2WaDW4dhAu5kLyiDzZDuNMrHyr3eo0wAglIaiEDd3fcOJ2SwzcPyUKWKUa8Ohgz8ORevE59BBPAUtFXoiIvOhZ9Xxdf0fqw38Df0SuZYHbZZxme2Rn3Zy6x-SK_bZetM2IXJZzGT7ViOweHE6ms1E4E4Fv0zfH04-jINg_Ac6BRXU |
| linkProvider | Springer Nature |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lj9MwELZWXQR74f0ILGAkEAeINg_HdpAQKo_VVttWFVrQcjKO4yyVSro0XaB_gJ_Db2TGTVqyCG574Bo7iu18882MPZ4h5CFWsI5MFvu5jsFBCcHdkTJmPiY-MQkvIuG2Bt73xXAoDw_T0Qb52dyFwbDKhhMdUedTg3vkO6AGwbROuGAvjr_4WDUKT1ebEhpLWOzbxTdw2arnvdfwfx9F0e6bg1d7fl1VwDdgPc_9Ik-Z1rIwWDuchRoP6qJE6jCTIo-tiJlLipeD58NtYo3WQWYLVuRhbAthsUoEUP4mA7DLDtkc9QajD6tzCyGDtLmaI_lOBewvIh_0oh_EeD8paKk_VyXgT13wmzI8Hah56rTWKcHdS__b8l0mF2tzm3aX8nGFbNjyKjk_qAMKrpEfowkY24Bd-nn8dtitntGmYgww34Ta73WccEnHJTWY7UHPFtTFwS5ofbhFdZlTvYZ5RXFzG3pjfAydFnRiiznFuFK32apnFNNnYz5milYFvnKdvDuTVbhBOuW0tLcIBb-BF8IEJs05K1iWsTBLWIYyFIBxKT3ypEGMOl5mIFHOc5NcLfGlAF_K4UsFHnmJoFr1xOzh7sF0dqRqMlIiMxY-yiNjYlaAjQo-ZpaY0OYCrEcbeuQxQlIhxwHujK6vasCAMVuY6oqEp5yBJ-2R7VZP4CbTbm7QqGpurNQaih55sGrGNzHer7TTE9eHSwGuNEzo5lIGVlOKweiVPIVRypZ0tObcbinHn1zm9BBWKU1S7pGnjSCtx_X3Rb3972ncJxf2DgZ91e8N9--QrciJu_DDaJt05rMTe5ecM1_n42p2r6YLSj6etYj9Ara4qEI |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZQQRUX3pRAASMhcYCoSezYDrflsQJRViseVW-W49iw0pKtNimif4DfzYyTbJsCB8Q1thU_xuP5PONvCHmMGawzW7K4MgwASgpwRynGYyQ-sbnwmQxXAwf7cjZTh4fF_Mwr_hDtPrgkuzcNyNJUt3tHle-2uBJ7DWhVmcVw3sQJw3c_ANovckwahHj948HGjyBVUgxPZf7YbnQcBdb-33XzmcPpfODkOe9pOJSmV_9_ONfIld4gpZNOgq6TC66-Qbbf9y73m-TnfAnmKKwu_bb4MJs0z-mQUwV0w5K6H30kbU0XNbXIh2DWJzREip7Q3v1DTV1RcyoIDcXrX6iNESR05enS-ZZi5GW4jjRrigTTyFhM8dzFJrfI5-nrTy_fxH3yhtgCSGljXxXcGOUtpmjnqUF_aJYrk5ZKVsxJxgP3YAUAU7jcWWOS0nnuq5Q5L13ObpOtelW7O4SCZS28tIktKsE9L0ueljkvUcoSML9URJ4Oa6iPOo4OHbCNErqbWg1Tq8PU6iQiL3CZNzWRXzt8WK2_6H67allaBz8VmbWMe7DiAIWVuU1dJcG-cmlEnqCQaNQCIAnW9I8ZoMPIp6UnMheF4IA1I7I7qgm7146LBzHTvfZoNJh8ACNzIXlEHm2KsSVGxNVudRzqCCUBbMKAdjqp3AyJgVmoRAG9VCN5HY15XFIvvgZu8RRmqcgLEZFng9ie9uvvk3r336o_JNvzV1O9_3b27h65nAXBl3Ga7ZKtdn3s7pNL9nu7aNYPwm7-BSaISy0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Platelet+miRNAs%3A+differential+expression+in+coronary+artery+disease+and+associations+with+course+of+left+ventricular+systolic+function&rft.jtitle=BMC+cardiovascular+disorders&rft.au=Goldschmied%2C+Andreas&rft.au=Drotleff%2C+Bernhard&rft.au=Winter%2C+Stefan&rft.au=Schaeffeler%2C+Elke&rft.date=2023-07-12&rft.issn=1471-2261&rft.eissn=1471-2261&rft.volume=23&rft.issue=1&rft_id=info:doi/10.1186%2Fs12872-023-03362-0&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_s12872_023_03362_0 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2261&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2261&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2261&client=summon |