Synthesis and Biological Application of Polylactic Acid

Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials....

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Vydané v:Molecules (Basel, Switzerland) Ročník 25; číslo 21; s. 5023
Hlavní autori: Li, Ge, Zhao, Menghui, Xu, Fei, Yang, Bo, Li, Xiangyu, Meng, Xiangxue, Teng, Lesheng, Sun, Fengying, Li, Youxin
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 29.10.2020
MDPI
Predmet:
Biocompatibility
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - therapeutic use
Biodegradable materials
Decomposition
drug delivery
Drug Delivery Systems
Drugs
FDA approval
Fermentation
Humans
implants
Industrial production
L- and D-lactic acid
Methods
Nanomaterials
PLA materials
Plastics
Polyesters - chemical synthesis
Polyesters - chemistry
Polyesters - therapeutic use
Polylactic acid
polymer
Polymerization
Polymers
Prostheses and Implants
R&D
Research & development
Review
Sutures
Tissue Engineering
polymer
l- and d-lactic acid
drug delivery
implants
PLA materials
ISSN:1420-3049, 1420-3049
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Popis
Shrnutí:Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25215023