Synthesis and Biological Application of Polylactic Acid

Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials....

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Published in:	Molecules (Basel, Switzerland) Vol. 25; no. 21; p. 5023
Main Authors:	Li, Ge, Zhao, Menghui, Xu, Fei, Yang, Bo, Li, Xiangyu, Meng, Xiangxue, Teng, Lesheng, Sun, Fengying, Li, Youxin
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 29.10.2020 MDPI
Subjects:	Biocompatibility Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - therapeutic use Biodegradable materials Decomposition drug delivery Drug Delivery Systems Drugs FDA approval Fermentation Humans implants Industrial production L- and D-lactic acid Methods Nanomaterials PLA materials Plastics Polyesters - chemical synthesis Polyesters - chemistry Polyesters - therapeutic use Polylactic acid polymer Polymerization Polymers Prostheses and Implants R&D Research & development Review Sutures Tissue Engineering polymer l- and d-lactic acid drug delivery implants PLA materials
ISSN:	1420-3049, 1420-3049
Online Access:	Get full text
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Abstract	Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications.
AbstractList	Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications. Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications.Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications.
Author	Zhao, Menghui Li, Ge Li, Youxin Teng, Lesheng Yang, Bo Li, Xiangyu Meng, Xiangxue Xu, Fei Sun, Fengying
AuthorAffiliation	School of Life Sciences, Jilin University, Changchun 130012, China; lige18@mails.jlu.edu.cn (G.L.); zhaomh18@mails.jlu.edu.cn (M.Z.); xufei19@mails.jlu.edu.cn (F.X.); yangb202020@163.com (B.Y.); lixiangyu19@mails.jlu.edu.cn (X.L.); mxx18@mails.jlu.edu.cn (X.M.); tenglesheng@jlu.edu.cn (L.T.)
AuthorAffiliation_xml	– name: School of Life Sciences, Jilin University, Changchun 130012, China; lige18@mails.jlu.edu.cn (G.L.); zhaomh18@mails.jlu.edu.cn (M.Z.); xufei19@mails.jlu.edu.cn (F.X.); yangb202020@163.com (B.Y.); lixiangyu19@mails.jlu.edu.cn (X.L.); mxx18@mails.jlu.edu.cn (X.M.); tenglesheng@jlu.edu.cn (L.T.)
Author_xml	– sequence: 1 givenname: Ge surname: Li fullname: Li, Ge – sequence: 2 givenname: Menghui orcidid: 0000-0002-2829-9126 surname: Zhao fullname: Zhao, Menghui – sequence: 3 givenname: Fei surname: Xu fullname: Xu, Fei – sequence: 4 givenname: Bo surname: Yang fullname: Yang, Bo – sequence: 5 givenname: Xiangyu surname: Li fullname: Li, Xiangyu – sequence: 6 givenname: Xiangxue surname: Meng fullname: Meng, Xiangxue – sequence: 7 givenname: Lesheng orcidid: 0000-0003-1623-5384 surname: Teng fullname: Teng, Lesheng – sequence: 8 givenname: Fengying orcidid: 0000-0001-6199-9311 surname: Sun fullname: Sun, Fengying – sequence: 9 givenname: Youxin orcidid: 0000-0002-0812-744X surname: Li fullname: Li, Youxin
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33138232$$D View this record in MEDLINE/PubMed
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Snippet	Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to...
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SubjectTerms	Biocompatibility Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - therapeutic use Biodegradable materials Decomposition drug delivery Drug Delivery Systems Drugs FDA approval Fermentation Humans implants Industrial production L- and D-lactic acid Methods Nanomaterials PLA materials Plastics Polyesters - chemical synthesis Polyesters - chemistry Polyesters - therapeutic use Polylactic acid polymer Polymerization Polymers Prostheses and Implants R&D Research & development Review Sutures Tissue Engineering
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Title	Synthesis and Biological Application of Polylactic Acid
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