Oxysterols and apolipoproteins in multiple sclerosis: a 5 year follow-up study

The purpose of this work was to investigate whether changes in oxysterol and apolipoprotein levels over 5 years are associated with disease course and disability progression in multiple sclerosis (MS). This study included 139 subjects [39 healthy controls (HCs), 61 relapsing-remitting MS (RR-MS) pat...

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Vydáno v:Journal of lipid research Ročník 60; číslo 7; s. 1190 - 1198
Hlavní autoři: Fellows Maxwell, Kelly, Bhattacharya, Sonia, Bodziak, Mary Lou, Jakimovski, Dejan, Hagemeier, Jesper, Browne, Richard W, Weinstock-Guttman, Bianca, Zivadinov, Robert, Ramanathan, Murali
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier 01.07.2019
Témata:
Adolescent
Adult
Aged
Apolipoproteins - blood
cholesterol
disease progression
Female
Follow-Up Studies
Humans
Hydroxycholesterols - blood
Ketocholesterols - blood
Longitudinal Studies
Male
Mass Spectrometry
metabolism
Middle Aged
Multiple Sclerosis - blood
Multiple Sclerosis - pathology
Oxysterols - blood
Prospective Studies
Young Adult
cholesterol
metabolism
disease progression
ISSN:1539-7262, 0022-2275, 1539-7262
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Shrnutí:The purpose of this work was to investigate whether changes in oxysterol and apolipoprotein levels over 5 years are associated with disease course and disability progression in multiple sclerosis (MS). This study included 139 subjects [39 healthy controls (HCs), 61 relapsing-remitting MS (RR-MS) patients, and 39 progressive MS (P-MS) patients]. Oxysterols [24-hydroxycholesterol (24HC), 25-hydroxycholesterol (25HC), 27-hydroxycholesterol (27HC), 7α-hydroxycholesterol (7αHC), and 7-ketocholesterol (7KC)] were measured at baseline and 5 years using a novel mass spectrometric method, and apolipoproteins were measured using immunoturbidometric diagnostic kits. Levels of 24HC ( = 0.004), 25HC ( = 0.029), and 27HC ( = 0.026) increased in P-MS patients. 7KC ( = 0.047) and 7αHC ( = 0.001) levels decreased in RR-MS patients, and there were no changes in any oxysterols in HCs. In MS patients, ApoC-II (all ≤ 0.01) and ApoE (all ≤ 0.01) changes were positively associated with all oxysterol levels. Increases in 24HC ( = 0.038) and ApoB ( = 0.038) and decreases in 7KC ( = 0.020) were observed in RR-MS patients who converted to secondary P-MS (SP-MS) at follow-up and in SP-MS patients compared with RR-MS patients. Oxysterols and their associations with apolipoproteins differed between MS patients and HCs over 5 years. Oxysterol and apolipoprotein changes were associated with conversion to SP-MS.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1539-7262
0022-2275
1539-7262
DOI:10.1194/jlr.M089664