Androgen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy

Background Endocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα). The androgen receptor (AR) is also expressed in the vast majority (80–90%) of ERα-positive tumors. AR-targeting drugs are not used in clinical practice,...

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Bibliographic Details
Published in:	Breast cancer research : BCR Vol. 26; no. 1; pp. 111 - 14
Main Authors:	Gao, Huanyao, Wei, Lixuan, Indulkar, Shreya, Nguyen, Thanh Thanh. L., Liu, Duan, Ho, Ming-Fen, Zhang, Cheng, Li, Hu, Weinshilboum, Richard M., Ingle, James N., Wang, Liewei
Format:	Journal Article
Language:	English
Published:	London BioMed Central 04.07.2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Agonists Androgen receptors Androgens Antineoplastic Agents, Hormonal - pharmacology Antineoplastic Agents, Hormonal - therapeutic use Aromatase Aromatase inhibitor Benzamides Biomedical and Life Sciences Biomedicine Biosynthesis Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer Research Cancer therapies Care and treatment Cell Line, Tumor Clinical trials Dihydrotestosterone Dihydrotestosterone - pharmacology Drug delivery Drug development Endocrine therapy Estrogen Estrogen receptors Estrogens Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene polymorphism Genes Genetic aspects Genome-Wide Association Study Genomes Genotype Globulins GWAS Hormones Humans Ligands Medical prognosis Nitriles - therapeutic use Oncology Oncology, Experimental Patients PGx-eQTL Pharmacodynamics Pharmacogenetics Pharmacogenetics - methods Pharmacogenomic Variants Pharmacogenomics Phenotypes Phenylthiohydantoin - pharmacology Phenylthiohydantoin - therapeutic use Polymorphism, Single Nucleotide Prostate Quantitative genetics Quantitative Trait Loci Receptors, Androgen - genetics Receptors, Androgen - metabolism Single nucleotide polymorphisms Single-nucleotide polymorphism Surgical Oncology Tumors Womens health Canada Aromatase inhibitor GWAS PGx-eQTL Androgen receptor Endocrine therapy Breast cancer Pharmacogenomics
ISSN:	1465-542X, 1465-5411, 1465-542X
Online Access:	Get full text
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