Geographical distribution of MTHFR C677T gene polymorphisms among the reproductive-age women in Chinese Han populations: based on migration

Background Methylenetetrahydrofolate reductase (MTHFR) is essential for the metabolism of folic acid and homocysteine. The MTHFR C677T polymorphism is associated with several disorders. Our study aims to explore the geographical distributions of the MTHFR C677T polymorphism of women in China and how...

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Veröffentlicht in:BMC women's health Jg. 24; H. 1; S. 407 - 9
Hauptverfasser: Shen, Yifen, Gu, Yongchun, Tang, Ying, Shen, Hao, Liu, Chao
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 18.07.2024
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Acids
Adult
Age
Alleles
Asian People - genetics
Asian People - statistics & numerical data
Birth defects
China - epidemiology
Chinese Han populations
Demographic aspects
East Asian People
Emigration and immigration
Enzymes
Equilibrium
Female
Folic acid
Gene Frequency
Genetic aspects
Genetic polymorphisms
Genotype
Genotype & phenotype
Geographical distribution
Gynecology
Health aspects
Health care
Homocysteine
Hospitals
Humans
Maternal and Child Health
Medicine
Medicine & Public Health
Metabolism
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Migration
Oxidoreductases
Polymorphism
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
Population
Precision medicine
Pregnancy
Preventive medicine
Provinces
Reproductive Medicine
Risk assessment
Risk factors
Statistics
Vitamin B
Vitamin deficiency
Women patients
Womens health
Young Adult
China
United States > US
Geographical distribution
Methylenetetrahydrofolate reductase
Chinese Han populations
Migration
Polymorphism
ISSN:1472-6874, 1472-6874
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Zusammenfassung:Background Methylenetetrahydrofolate reductase (MTHFR) is essential for the metabolism of folic acid and homocysteine. The MTHFR C677T polymorphism is associated with several disorders. Our study aims to explore the geographical distributions of the MTHFR C677T polymorphism of women in China and how migration affected the polymorphism in Suzhou. Methods A total of 7188 women of reproductive age were recruited in Suzhou of the study. Subjects were classified according to their native places after data extraction. MTHFR C677T gene polymorphisms were detected by quantitative PCR with genomic DNA isolated from blood samples. Results The frequencies of the 677T allele and 677TT genotype were higher in northern China than that in southern China and decreased in geographical gradients from north to south. The frequencies were considerably higher in the migrant population than that in the indigenous population of Suzhou. The migrant population have gradually changed the prevalence in Suzhou. Conclusions Our study suggested that the prevalence of MTHFR C677T polymorphisms among women varied across different geographical regions in Chinese Han populations. The 677T allele frequencies of the northern populations were significantly higher than those of the southern populations. The migrant population gradually changed the prevalence of the MTHFR C677T polymorphism in Suzhou.
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ISSN:1472-6874
1472-6874
DOI:10.1186/s12905-024-03244-3