Facilitated diffusion with DNA coiling

When DNA-binding proteins search for their specific binding site on a DNA molecule they alternate between linear 1-dimensional diffusion along the DNA molecule, mediated by nonspecific binding, and 3-dimensional volume excursion events between successive dissociation from and rebinding to DNA. If th...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 20; p. 8204
Main Authors:	Lomholt, Michael A, van den Broek, Bram, Kalisch, Svenja-Marei J, Wuite, Gijs J L, Metzler, Ralf
Format:	Journal Article
Language:	English
Published:	United States 19.05.2009
Subjects:	Diffusion DNA - chemistry DNA-Binding Proteins - metabolism Models, Molecular Nucleic Acid Conformation Protein Binding
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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