Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first consider the formation of the upper rhombic lip, from which all granule cell precursors arise, and the way by whi...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Frontiers in neural circuits Ročník 14; s. 611841
Hlavní autoři:	Consalez, G. Giacomo, Goldowitz, Daniel, Casoni, Filippo, Hawkes, Richard
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland Frontiers Research Foundation 15.01.2021 Frontiers Media S.A
Témata:	Bergmann glial fibers Cerebellum Climbing compartmentation Epithelium external granular layer granule cell Granule cells Neurons Neuroscience Phenotypes radial migration Reviews upper rhombic lip compartmentation upper rhombic lip Bergmann glial fibers radial migration cerebellum external granular layer granule cell
ISSN:	1662-5110, 1662-5110
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first consider the formation of the upper rhombic lip, from which all granule cell precursors arise, and the way by which the upper rhombic lip generates the external granular layer, a secondary germinal epithelium that serves to amplify the upper rhombic lip precursors. Next, we review the mechanisms by which postmitotic granule cells are generated in the external granular layer and migrate radially to settle in the granular layer. In addition, we review the evidence that far from being a homogeneous population, granule cells come in multiple phenotypes with distinct topographical distributions and consider ways in which the heterogeneity of granule cells might arise during development.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 These authors have contributed equally to this work and share first authorship Edited by: Eduardo Weruaga, University of Salamanca, Spain Reviewed by: Mitsuhiro Hashimoto, Fukushima Medical University, Japan; Tetsushi Sadakata, Gunma University, Japan
ISSN:	1662-5110 1662-5110
DOI:	10.3389/fncir.2020.611841