Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma

While molecular subtypes of glioblastoma (GBM) are defined using gene expression and mutation profiles, we identify a unique subpopulation based on addiction to the high-affinity glucose transporter, Glut3. Although Glut3 is a known driver of a cancer stem cell phenotype, direct targeting is complic...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer cell Vol. 32; no. 6; p. 856
Main Authors:	Cosset, Érika, Ilmjärv, Sten, Dutoit, Valérie, Elliott, Kathryn, von Schalscha, Tami, Camargo, Maria F, Reiss, Alexander, Moroishi, Toshiro, Seguin, Laetitia, Gomez, German, Moo, Jung-Soon, Preynat-Seauve, Olivier, Krause, Karl-Heinz, Chneiweiss, Hervé, Sarkaria, Jann N, Guan, Kun-Liang, Dietrich, Pierre-Yves, Weis, Sara M, Mischel, Paul S, Cheresh, David A
Format:	Journal Article
Language:	English
Published:	United States 11.12.2017
Subjects:	Animals Antineoplastic Agents - pharmacology Brain Neoplasms - metabolism Brain Neoplasms - mortality Cell Line, Tumor Gene Expression Profiling Glioblastoma - metabolism Glioblastoma - mortality Glucose Transporter Type 3 - metabolism Humans Integrin alphaVbeta3 - metabolism Kaplan-Meier Estimate Mice Mice, Nude Signal Transduction Snake Venoms - pharmacology Transcriptome Xenograft Model Antitumor Assays glioblastoma cancer stem cells Glut3 integrin glucose metabolism
ISSN:	1878-3686, 1878-3686
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!