Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy

Vascular contributions to cognitive impairment and dementia (VCID) are a common cause of cognitive decline, yet limited therapies exist. This cerebrovascular disease results in neurodegeneration via acute, chronic, local, and systemic mechanisms. The etiology of VCID is complex, with a significant i...

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Bibliographic Details
Published in:	Frontiers in aging neuroscience Vol. 13; p. 647990
Main Authors:	Duong, Michael Tran, Nasrallah, Ilya M., Wolk, David A., Chang, Catherine C. Y., Chang, Ta-Yuan
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Research Foundation 25.03.2021 Frontiers Media S.A
Subjects:	Alzheimer's disease APOE Apolipoprotein E Apolipoprotein E4 Arteriosclerosis Astrocytes Atherosclerosis Blood flow Blood-brain barrier Carotid arteries Carotid artery Cell activation Cerebral blood flow Cerebrovascular diseases Cholesterol Clinical aspects Cognitive ability Dementia Dementia disorders Dyslipidemia Endothelial cells Etiology glia Homeostasis Hypercholesterolemia Inflammation Ischemia Lipids Metabolism Microglia Neurodegeneration Neurodegenerative diseases Neuroscience Pathology Proteins Risk factors Smooth muscle Stroke vascular dementia Veins & arteries atherosclerosis inflammation vascular dementia cholesterol macrophage APOE glia
ISSN:	1663-4365, 1663-4365
Online Access:	Get full text
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