A Diversity of Intrinsic Timescales Underlie Neural Computations

Neural processing occurs across a range of temporal scales. To facilitate this, the brain uses fast-changing representations reflecting momentary sensory input alongside more temporally extended representations, which integrate across both short and long temporal windows. The temporal flexibility of...

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Published in:	Frontiers in neural circuits Vol. 14; p. 615626
Main Authors:	Cavanagh, Sean E., Hunt, Laurence T., Kennerley, Steven W.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Research Foundation 21.12.2020 Frontiers Media S.A
Subjects:	Animals autocorrelation Brain - physiology Brain research Cerebral Cortex - physiology Cognitive ability Computational neuroscience Decision making Electrophysiology Humans Information processing Listening Medical imaging Memory, Short-Term - physiology Nerve Net - physiology Neural networks Neural Pathways - physiology Neuroimaging neuronal timescale Neurons Neurons - physiology Neuroscience Short term memory time constant working memory time constant decision-making working memory neuronal timescale autocorrelation
ISSN:	1662-5110, 1662-5110
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Abstract	Neural processing occurs across a range of temporal scales. To facilitate this, the brain uses fast-changing representations reflecting momentary sensory input alongside more temporally extended representations, which integrate across both short and long temporal windows. The temporal flexibility of these representations allows animals to behave adaptively. Short temporal windows facilitate adaptive responding in dynamic environments, while longer temporal windows promote the gradual integration of information across time. In the cognitive and motor domains, the brain sets overarching goals to be achieved within a long temporal window, which must be broken down into sequences of actions and precise movement control processed across much shorter temporal windows. Previous human neuroimaging studies and large-scale artificial network models have ascribed different processing timescales to different cortical regions, linking this to each region’s position in an anatomical hierarchy determined by patterns of inter-regional connectivity. However, even within cortical regions, there is variability in responses when studied with single-neuron electrophysiology. Here, we review a series of recent electrophysiology experiments that demonstrate the heterogeneity of temporal receptive fields at the level of single neurons within a cortical region. This heterogeneity appears functionally relevant for the computations that neurons perform during decision-making and working memory. We consider anatomical and biophysical mechanisms that may give rise to a heterogeneity of timescales, including recurrent connectivity, cortical layer distribution, and neurotransmitter receptor expression. Finally, we reflect on the computational relevance of each brain region possessing a heterogeneity of neuronal timescales. We argue that this architecture is of particular importance for sensory, motor, and cognitive computations.
AbstractList	Neural processing occurs across a range of temporal scales. To facilitate this, the brain uses fast-changing representations reflecting momentary sensory input alongside more temporally extended representations, which integrate across both short and long temporal windows. The temporal flexibility of these representations allows animals to behave adaptively. Short temporal windows facilitate adaptive responding in dynamic environments, while longer temporal windows promote the gradual integration of information across time. In the cognitive and motor domains, the brain sets overarching goals to be achieved within a long temporal window, which must be broken down into sequences of actions and precise movement control processed across much shorter temporal windows. Previous human neuroimaging studies and large-scale artificial network models have ascribed different processing timescales to different cortical regions, linking this to each region’s position in an anatomical hierarchy determined by patterns of inter-regional connectivity. However, even within cortical regions, there is variability in responses when studied with single-neuron electrophysiology. Here, we review a series of recent electrophysiology experiments that demonstrate the heterogeneity of temporal receptive fields at the level of single neurons within a cortical region. This heterogeneity appears functionally relevant for the computations that neurons perform during decision-making and working memory. We consider anatomical and biophysical mechanisms that may give rise to a heterogeneity of timescales, including recurrent connectivity, cortical layer distribution, and neurotransmitter receptor expression. Finally, we reflect on the computational relevance of each brain region possessing a heterogeneity of neuronal timescales. We argue that this architecture is of particular importance for sensory, motor, and cognitive computations. Neural processing occurs across a range of temporal scales. To facilitate this, the brain uses fast-changing representations reflecting momentary sensory input alongside more temporally extended representations, which integrate across both short and long temporal windows. The temporal flexibility of these representations allows animals to behave adaptively. Short temporal windows facilitate adaptive responding in dynamic environments, while longer temporal windows promote the gradual integration of information across time. In the cognitive and motor domains, the brain sets overarching goals to be achieved within a long temporal window, which must be broken down into sequences of actions and precise movement control processed across much shorter temporal windows. Previous human neuroimaging studies and large-scale artificial network models have ascribed different processing timescales to different cortical regions, linking this to each region’s position in an anatomical hierarchy determined by patterns of inter-regional connectivity. However, even within cortical regions, there is variability in responses when studied with single neuron electrophysiology. Here, we review a series of recent electrophysiology experiments that demonstrate a heterogeneity of temporal receptive fields at the level of single neurons within a cortical region. This heterogeneity appears functionally relevant for the computations that neurons perform during decision-making and working memory. We consider anatomical and biophysical mechanisms which may give rise to a heterogeneity of timescales, including recurrent connectivity, cortical layer distribution, and neurotransmitter receptor expression. Finally, we reflect on the computational relevance of each brain region possessing a heterogeneity of neuronal timescales. We argue that this architecture is of particular importance for sensory, motor, and cognitive computations. Neural processing occurs across a range of temporal scales. To facilitate this, the brain uses fast-changing representations reflecting momentary sensory input alongside more temporally extended representations, which integrate across both short and long temporal windows. The temporal flexibility of these representations allows animals to behave adaptively. Short temporal windows facilitate adaptive responding in dynamic environments, while longer temporal windows promote the gradual integration of information across time. In the cognitive and motor domains, the brain sets overarching goals to be achieved within a long temporal window, which must be broken down into sequences of actions and precise movement control processed across much shorter temporal windows. Previous human neuroimaging studies and large-scale artificial network models have ascribed different processing timescales to different cortical regions, linking this to each region's position in an anatomical hierarchy determined by patterns of inter-regional connectivity. However, even within cortical regions, there is variability in responses when studied with single-neuron electrophysiology. Here, we review a series of recent electrophysiology experiments that demonstrate the heterogeneity of temporal receptive fields at the level of single neurons within a cortical region. This heterogeneity appears functionally relevant for the computations that neurons perform during decision-making and working memory. We consider anatomical and biophysical mechanisms that may give rise to a heterogeneity of timescales, including recurrent connectivity, cortical layer distribution, and neurotransmitter receptor expression. Finally, we reflect on the computational relevance of each brain region possessing a heterogeneity of neuronal timescales. We argue that this architecture is of particular importance for sensory, motor, and cognitive computations.Neural processing occurs across a range of temporal scales. To facilitate this, the brain uses fast-changing representations reflecting momentary sensory input alongside more temporally extended representations, which integrate across both short and long temporal windows. The temporal flexibility of these representations allows animals to behave adaptively. Short temporal windows facilitate adaptive responding in dynamic environments, while longer temporal windows promote the gradual integration of information across time. In the cognitive and motor domains, the brain sets overarching goals to be achieved within a long temporal window, which must be broken down into sequences of actions and precise movement control processed across much shorter temporal windows. Previous human neuroimaging studies and large-scale artificial network models have ascribed different processing timescales to different cortical regions, linking this to each region's position in an anatomical hierarchy determined by patterns of inter-regional connectivity. However, even within cortical regions, there is variability in responses when studied with single-neuron electrophysiology. Here, we review a series of recent electrophysiology experiments that demonstrate the heterogeneity of temporal receptive fields at the level of single neurons within a cortical region. This heterogeneity appears functionally relevant for the computations that neurons perform during decision-making and working memory. We consider anatomical and biophysical mechanisms that may give rise to a heterogeneity of timescales, including recurrent connectivity, cortical layer distribution, and neurotransmitter receptor expression. Finally, we reflect on the computational relevance of each brain region possessing a heterogeneity of neuronal timescales. We argue that this architecture is of particular importance for sensory, motor, and cognitive computations.
Author	Cavanagh, Sean E. Hunt, Laurence T. Kennerley, Steven W.
AuthorAffiliation	2 Wellcome Trust Centre for Neuroimaging, University College London , London , United Kingdom 4 Department of Psychiatry, Wellcome Centre for Integrative Neuroimaging, University of Oxford , Oxford , United Kingdom 3 Max Planck-UCL Centre for Computational Psychiatry and Aging, University College London , London , United Kingdom 1 Department of Clinical and Movement Neurosciences, University College London , London , United Kingdom
AuthorAffiliation_xml	– name: 3 Max Planck-UCL Centre for Computational Psychiatry and Aging, University College London , London , United Kingdom – name: 1 Department of Clinical and Movement Neurosciences, University College London , London , United Kingdom – name: 4 Department of Psychiatry, Wellcome Centre for Integrative Neuroimaging, University of Oxford , Oxford , United Kingdom – name: 2 Wellcome Trust Centre for Neuroimaging, University College London , London , United Kingdom
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Cites_doi	10.7554/eLife.11945 10.1093/cercor/bht031 10.1146/annurev.neuro.24.1.167 10.1073/pnas.1504172112 10.1126/science.1088545 10.1016/j.neuron.2015.01.007 10.1152/jn.2000.84.4.2148 10.1371/journal.pcbi.1000209 10.1016/j.neuron.2016.02.018 10.1523/JNEUROSCI.2062-09.2010 10.1038/s41583-020-0262-x 10.1023/a:1011204814320 10.1523/JNEUROSCI.20-18-j0002.2000 10.1152/jn.2001.86.3.1445 10.1016/j.neuron.2015.10.010 10.1038/nn.3017 10.1016/j.conb.2010.02.009 10.1016/j.neuron.2015.09.008 10.1371/journal.pcbi.1004667 10.1093/cercor/bhi003 10.1038/s41593-019-0535-8 10.1016/j.neuron.2012.12.032 10.1038/s41467-018-05873-3 10.1038/nature12742 10.1523/JNEUROSCI.2984-12.2013 10.1038/s41467-018-05961-4 10.1093/cercor/bhx321 10.1093/cercor/1.1.1 10.1016/s0896-6273(02)01092-9 10.1016/j.conb.2010.03.001 10.1038/nature24636 10.1038/nn.2842 10.7554/eLife.54313 10.1101/805010 10.7554/eLife.08825 10.1016/j.neuron.2020.05.020 10.1016/j.cub.2019.05.037 10.1038/nature17192 10.1124/pr.115.010512 10.1016/j.conb.2015.12.010 10.1038/s41467-018-06561-y 10.1016/j.neuron.2014.04.045 10.1038/nn1954 10.1093/cercor/6.3.342 10.1038/nn.2971 10.1038/s41593-017-0028-6 10.1016/0896-6273(94)90210-0 10.1038/s41586-019-1346-5 10.1093/cercor/7.7.635 10.1101/2020.02.11.944751 10.1016/j.neuron.2017.06.013 10.1126/science.1172377 10.1016/j.neuron.2016.02.009 10.1038/s41593-018-0195-0 10.1016/j.isci.2018.11.033 10.1038/nrn2478 10.1152/jn.01066.2009 10.1146/annurev.neuro.29.051605.113038 10.1523/ENEURO.0169-18.2018 10.1073/pnas.1619449114 10.1073/pnas.2005993117 10.1093/cercor/bhw062 10.1016/j.neuron.2011.02.027 10.7554/eLife.14472 10.1038/nn.3423 10.7554/eLife.52460 10.1073/pnas.0305337101 10.1016/j.neuron.2016.07.015 10.1038/nature11129 10.1523/JNEUROSCI.2221-13.2013 10.1093/cercor/bhaa056 10.1016/j.tics.2015.05.004 10.1016/j.neuron.2018.06.033 10.1038/nature12160 10.1038/s41467-017-02169-w 10.7554/eLife.53664 10.1016/j.tics.2015.04.006 10.7554/eLife.12112 10.1038/nn.2398 10.1038/35082081 10.7554/eLife.01239 10.1523/JNEUROSCI.2369-07.2007 10.1523/JNEUROSCI.04-03-00880.1984 10.1016/j.cell.2017.05.011 10.1146/annurev.ne.19.030196.000545 10.1038/nn.2635 10.1038/20939 10.1038/nature10918 10.1016/j.neuron.2012.09.029 10.1523/JNEUROSCI.3684-10.2011 10.1126/science.aaa4056 10.1016/j.neuron.2017.06.041 10.1073/pnas.1710323115 10.1101/2020.08.20.259192 10.1093/cercor/bhg093 10.1016/j.neuron.2012.08.011 10.1038/nn.3865 10.1016/0896-6273(95)90304-6 10.1093/cercor/bhs270 10.1152/jn.00268.2013 10.1038/nrn.2017.7 10.1002/cne.903590109 10.1002/cne.23458 10.1016/j.conb.2016.01.010 10.1038/nn.2752 10.1152/jn.1989.61.2.331 10.1523/JNEUROSCI.2485-17.2018 10.1038/nn1278 10.1016/j.cub.2013.04.039 10.1016/j.neuron.2013.10.047 10.1038/nn.3862 10.1016/j.neuron.2019.06.017 10.1113/jphysiol.1968.sp008455 10.1152/jn.1998.79.2.555 10.3389/fnana.2011.00002 10.7554/eLife.18937 10.1016/j.neuron.2019.01.017 10.1068/p270889 10.1016/j.tics.2008.02.004 10.1073/pnas.0804318105 10.1097/00001756-199212000-00027 10.1038/s41593-019-0487-z 10.1016/j.neuroscience.2006.12.072 10.1523/JNEUROSCI.2486-17.2018 10.1523/JNEUROSCI.0251-18.2018 10.1016/j.neuron.2008.12.012 10.1038/nn.4403 10.1016/j.cognition.2008.08.011 10.1016/j.neuron.2014.12.018 10.1113/jphysiol.1962.sp006837 10.1038/nature23020 10.1523/JNEUROSCI.5487-07.2008 10.1016/s0166-2236(00)01868-3 10.1002/cne.903110403 10.1523/JNEUROSCI.19-06-02209.1999 10.1038/nature14182 10.1007/BF00271862
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Copyright	Copyright © 2020 Cavanagh, Hunt and Kennerley. 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2020 Cavanagh, Hunt and Kennerley. 2020 Cavanagh, Hunt and Kennerley
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Keywords	time constant decision-making working memory neuronal timescale autocorrelation
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References	Hubel (B62) 1962; 160 Wallis (B127) 2001; 411 Cavanagh (B21) 2020; 9 Goldman-Rakic (B53) 1995; 14 Ossmy (B100) 2013; 23 Gold (B51) 2007; 30 Bronfman (B15) 2016; 12 Latimer (B76) 2015; 349 Levi (B80) 2018; 5 Harvey (B56) 2012; 484 Romo (B107) 1999; 399 Sutton (B122) 1998 Yokoi (B138) 2019; 103 Finn (B43) 2019; 22 Murray (B93) 2014; 17 Watanabe (B137) 1992; 3 Nauhaus (B96) 2016; 91 Rajan (B103) 2016; 90 Rangel (B104) 2010; 20 Bastos (B7) 2018; 115 Seo (B112) 2007; 27 Wang (B129) 2018; 21 Churchland (B300) 2012; 487 Meder (B88) 2017; 8 B31 Hunt (B64) 2017; 18 Bastos (B8) 2015; 85 Wang (B135) 2004; 101 Siegle (B116) 2019 Croxson (B33) 2011; 14 Shima (B115) 2000; 84 Glaze (B49) 2015; 4 Lerner (B79) 2011; 31 Arnsten (B1) 2015; 67 Cirillo (B28) 2018; 10 Chang (B24) 2017; 169 Hasson (B57) 2015; 19 Wang (B131) 2016; 37 Nishida (B98) 2014; 24 Stephens (B119) 2013; 110 Wasmuht (B136) 2018; 9 Jun (B68) 2017; 551 Tanaka (B123) 1996; 19 Fusi (B46) 2016; 37 Demirtaş (B35) 2019; 101 Krajbich (B74) 2010; 13 Kim (B71) 2020 Meister (B89) 2013; 33 Chaudhuri (B25) 2014; 3 Runyan (B108) 2017; 548 Ogawa (B99) 2010; 103 Ganupuru (B47) 2019; 29 Rigotti (B106) 2013; 497 Benucci (B10) 2009; 12 Azouz (B2) 1999; 19 Shadlen (B113) 2013; 80 Brincat (B14) 2004; 7 Honey (B60) 2012; 76 Miller (B90) 2001; 24 Hennequin (B59) 2014; 82 Murray (B94) 2017; 114 Hunt (B65) 2015; 4 Gnadt (B50) 1988; 70 Baldassano (B5) 2018; 38 Gur (B54) 2005; 15 Wang (B130) 2013; 77 Elston (B37) 2000; 20 Luppino (B82) 1991; 311 Cavanagh (B23) 2016; 5 Buckley (B17) 2009; 325 Wallis (B126) 2010; 20 Stokes (B120) 2015; 19 Behrens (B9) 2007; 10 Kiebel (B70) 2008; 4 Bernacchia (B11) 2011; 14 Barbas (B6) 1997; 7 Vicini (B125) 1998; 79 Picard (B101) 1996; 6 Dragomir (B36) 2020; 23 Hubel (B63) 1968; 195 Torres-Gomez (B124) 2020; 30 Wang (B132) 2001; 24 Shafi (B114) 2007; 146 Chaudhuri (B26) 2015; 88 Funahashi (B45) 1989; 61 Hasson (B58) 2008; 28 Gilman (B48) 2017; 27 Wang (B128) 2008; 105 Buckner (B18) 2013; 16 Morcos (B92) 2016; 19 Sofroniew (B117) 2016; 5 Massi (B87) 2018; 99 Piet (B102) 2018; 9 Blasdel (B12) 1984; 4 Raposo (B105) 2014; 17 Enel (B40) 2020; 9 Constantinidis (B30) 2018; 38 Kritzer (B75) 1995; 359 Botvinick (B13) 2009; 113 Fascianelli (B41) 2019; 29 Fontanier (B44) 2020 Cohen (B29) 2011; 14 Nee (B97) 2016; 5 Hunt (B66) 2012; 15 Markowitz (B86) 2015; 112 Nachev (B95) 2008; 9 Stringer (B121) 2019; 571 Elston (B38) 2003; 13 Jun (B69) 2010; 30 Lundqvist (B81) 2018; 38 Hart (B55) 2020; 9 Goldman (B52) 2009; 61 Brunel (B16) 2001; 11 Buschman (B20) 2012; 76 Markov (B84); 24 Lee (B77) 2016; 532 Chen (B27) 2015; 88 Elston (B39) 2011; 5 Koechlin (B73) 2003; 302 Cossell (B32) 2015; 518 Daw (B34) 2011; 69 Cavanagh (B22) 2018; 9 Badre (B3) 2008; 12 Mante (B83) 2013; 503 Felleman (B42) 1991; 1 Sen (B111) 2001; 86 Burt (B19) 2018; 21 Wang (B134) 2020; 21 Hosokawa (B61) 2013; 33 Russo (B109) 2020; 107 Scott (B110) 2017; 95 Wang (B133) 2002; 36 Monyer (B91) 1994; 12 Kira (B72) 2015; 85 Baldassano (B4) 2017; 95 Markov (B85); 522 Jocham (B67) 2016; 90 Spitmaan (B118) 2020 Lennie (B78) 1998; 27
References_xml	– volume: 4 start-page: e11945 year: 2015 ident: B65 article-title: Capturing the temporal evolution of choice across prefrontal cortex publication-title: eLife doi: 10.7554/eLife.11945 – volume: 24 start-page: 1671 year: 2014 ident: B98 article-title: Discharge-rate persistence of baseline activity during fixation reflects maintenance of memory-period activity in the macaque posterior parietal cortex publication-title: Cereb. Cortex doi: 10.1093/cercor/bht031 – volume: 24 start-page: 167 year: 2001 ident: B90 article-title: An integrative theory of prefrontal cortex function publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.24.1.167 – volume: 112 start-page: 11084 year: 2015 ident: B86 article-title: Multiple component networks support working memory in prefrontal cortex publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1504172112 – volume: 302 start-page: 1181 year: 2003 ident: B73 article-title: The architecture of cognitive control in the human prefrontal cortex publication-title: Science doi: 10.1126/science.1088545 – volume: 85 start-page: 861 year: 2015 ident: B72 article-title: A neural implementation of Wald’s sequential probability ratio test publication-title: Neuron doi: 10.1016/j.neuron.2015.01.007 – volume: 84 start-page: 2148 year: 2000 ident: B115 article-title: Neuronal activity in the supplementary and presupplementary motor areas for temporal organization of multiple movements publication-title: J. Neurophysiol. doi: 10.1152/jn.2000.84.4.2148 – volume: 4 start-page: e1000209 year: 2008 ident: B70 article-title: A hierarchy of time-scales and the brain publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1000209 – volume: 90 start-page: 177 year: 2016 ident: B67 article-title: Reward-guided learning with and without causal attribution publication-title: Neuron doi: 10.1016/j.neuron.2016.02.018 – volume: 30 start-page: 916 year: 2010 ident: B69 article-title: Heterogenous population coding of a short-term memory and decision task publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2062-09.2010 – volume: 21 start-page: 169 year: 2020 ident: B134 article-title: Macroscopic gradients of synaptic excitation and inhibition in the neocortex publication-title: Nat. Rev. Neurosci. doi: 10.1038/s41583-020-0262-x – volume: 11 start-page: 63 year: 2001 ident: B16 article-title: Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition publication-title: J. Comput. Neurosci. doi: 10.1023/a:1011204814320 – volume: 20 start-page: RC95 year: 2000 ident: B37 article-title: Pyramidal cells of the frontal lobe: all the more spinous to think with publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.20-18-j0002.2000 – volume: 86 start-page: 1445 year: 2001 ident: B111 article-title: Feature analysis of natural sounds in the songbird auditory forebrain publication-title: J. Neurophysiol. doi: 10.1152/jn.2001.86.3.1445 – volume: 88 start-page: 244 year: 2015 ident: B27 article-title: Processing timescales as an organizing principle for primate cortex publication-title: Neuron doi: 10.1016/j.neuron.2015.10.010 – volume: 15 start-page: S471 year: 2012 ident: B66 article-title: Mechanisms underlying cortical activity during value-guided choice publication-title: Nat. Neurosci. doi: 10.1038/nn.3017 – volume: 20 start-page: 191 year: 2010 ident: B126 article-title: Heterogeneous reward signals in prefrontal cortex publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2010.02.009 – volume: 88 start-page: 419 year: 2015 ident: B26 article-title: A large-scale circuit mechanism for hierarchical dynamical processing in the primate cortex publication-title: Neuron doi: 10.1016/j.neuron.2015.09.008 – volume: 12 start-page: e1004667 year: 2016 ident: B15 article-title: Non-monotonic temporal-weighting indicates a dynamically modulated evidence-integration mechanism publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1004667 – volume: 15 start-page: 1207 year: 2005 ident: B54 article-title: Orientation and direction selectivity of neurons in V1 of alert monkeys: functional relationships and laminar distributions publication-title: Cereb. Cortex doi: 10.1093/cercor/bhi003 – volume: 23 start-page: 85 year: 2020 ident: B36 article-title: Evidence accumulation during a sensorimotor decision task revealed by whole-brain imaging publication-title: Nat. Neurosci. doi: 10.1038/s41593-019-0535-8 – volume: 77 start-page: 736 year: 2013 ident: B130 article-title: NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex publication-title: Neuron doi: 10.1016/j.neuron.2012.12.032 – volume: 9 start-page: 3498 year: 2018 ident: B22 article-title: Reconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex publication-title: Nat. Commun. doi: 10.1038/s41467-018-05873-3 – volume: 503 start-page: 78 year: 2013 ident: B83 article-title: Context-dependent computation by recurrent dynamics in prefrontal cortex publication-title: Nature doi: 10.1038/nature12742 – volume: 33 start-page: 2254 year: 2013 ident: B89 article-title: Signal multiplexing and single-neuron computations in lateral intraparietal area during decision-making publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2984-12.2013 – volume: 9 start-page: 3499 year: 2018 ident: B136 article-title: Intrinsic neuronal dynamics predict distinct functional roles during working memory publication-title: Nat. Commun. doi: 10.1038/s41467-018-05961-4 – volume: 29 start-page: 230 year: 2019 ident: B41 article-title: Autocorrelation structure in the macaque dorsolateral, but not orbital or polar, prefrontal cortex predicts response-coding strength in a visually cued strategy task publication-title: Cereb. Cortex doi: 10.1093/cercor/bhx321 – volume: 1 start-page: 1 year: 1991 ident: B42 article-title: Distributed hierarchical processing in the primate cerebral cortex publication-title: Cereb. Cortex doi: 10.1093/cercor/1.1.1 – volume: 36 start-page: 955 year: 2002 ident: B133 article-title: Probabilistic decision making by slow reverberation in cortical circuits publication-title: Neuron doi: 10.1016/s0896-6273(02)01092-9 – volume: 20 start-page: 262 year: 2010 ident: B104 article-title: Neural computations associated with goal-directed choice publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2010.03.001 – volume: 551 start-page: 232 year: 2017 ident: B68 article-title: Fully integrated silicon probes for high-density recording of neural activity publication-title: Nature doi: 10.1038/nature24636 – volume: 14 start-page: 811 year: 2011 ident: B29 article-title: Measuring and interpreting neuronal correlations publication-title: Nat. Neurosci. doi: 10.1038/nn.2842 – volume: 9 start-page: e54313 year: 2020 ident: B40 article-title: Stable and dynamic representations of value in the prefrontal cortex publication-title: eLife doi: 10.7554/eLife.54313 – year: 2019 ident: B116 article-title: A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas publication-title: bioRxiv doi: 10.1101/805010 – volume: 4 start-page: e08825 year: 2015 ident: B49 article-title: Normative evidence accumulation in unpredictable environments publication-title: eLife doi: 10.7554/eLife.08825 – volume: 107 start-page: 745.e6 year: 2020 ident: B109 article-title: Neural trajectories in the supplementary motor area and motor cortex exhibit distinct geometries, compatible with different classes of computation publication-title: Neuron doi: 10.1016/j.neuron.2020.05.020 – volume: 29 start-page: 2091.e4 year: 2019 ident: B47 article-title: Flexibility of timescales of evidence evaluation for decision making publication-title: Curr. Biol. doi: 10.1016/j.cub.2019.05.037 – volume: 532 start-page: 370 year: 2016 ident: B77 article-title: Anatomy and function of an excitatory network in the visual cortex publication-title: Nature doi: 10.1038/nature17192 – volume: 67 start-page: 681 year: 2015 ident: B1 article-title: Dopamine’s actions in primate prefrontal cortex: challenges for treating cognitive disorders publication-title: Pharmacol. Rev. doi: 10.1124/pr.115.010512 – volume: 37 start-page: 92 year: 2016 ident: B131 article-title: Brain structure and dynamics across scales: in search of rules publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2015.12.010 – volume: 9 start-page: 4265 year: 2018 ident: B102 article-title: Rats adopt the optimal timescale for evidence integration in a dynamic environment publication-title: Nat. Commun. doi: 10.1038/s41467-018-06561-y – volume: 82 start-page: 1394 year: 2014 ident: B59 article-title: Optimal control of transient dynamics in balanced networks supports generation of complex movements publication-title: Neuron doi: 10.1016/j.neuron.2014.04.045 – volume: 10 start-page: 1214 year: 2007 ident: B9 article-title: Learning the value of information in an uncertain world publication-title: Nat. Neurosci. doi: 10.1038/nn1954 – volume: 6 start-page: 342 year: 1996 ident: B101 article-title: Motor areas of the medial wall: a review of their location and functional activation publication-title: Cereb. Cortex doi: 10.1093/cercor/6.3.342 – volume: 14 start-page: 1510 year: 2011 ident: B33 article-title: Cholinergic modulation of a specific memory function of prefrontal cortex publication-title: Nat. Neurosci. doi: 10.1038/nn.2971 – volume: 21 start-page: 102 year: 2018 ident: B129 article-title: Flexible timing by temporal scaling of cortical responses publication-title: Nat. Neurosci. doi: 10.1038/s41593-017-0028-6 – volume: 12 start-page: 529 year: 1994 ident: B91 article-title: Developmental and regional expression in the rat brain and functional properties of four NMDA receptors publication-title: Neuron doi: 10.1016/0896-6273(94)90210-0 – volume: 571 start-page: 361 year: 2019 ident: B121 article-title: High-dimensional geometry of population responses in visual cortex publication-title: Nature doi: 10.1038/s41586-019-1346-5 – volume: 7 start-page: 635 year: 1997 ident: B6 article-title: Cortical structure predicts the pattern of corticocortical connections publication-title: Cereb. Cortex doi: 10.1093/cercor/7.7.635 – year: 2020 ident: B71 article-title: Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks publication-title: bioRxiv doi: 10.1101/2020.02.11.944751 – volume: 95 start-page: 385.e5 year: 2017 ident: B110 article-title: Fronto-parietal cortical circuits encode accumulated evidence with a diversity of timescales publication-title: Neuron doi: 10.1016/j.neuron.2017.06.013 – volume: 325 start-page: 52 year: 2009 ident: B17 article-title: Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions publication-title: Science doi: 10.1126/science.1172377 – volume: 90 start-page: 128 year: 2016 ident: B103 article-title: Recurrent network models of sequence generation and memory publication-title: Neuron doi: 10.1016/j.neuron.2016.02.009 – volume: 21 start-page: 1251 year: 2018 ident: B19 article-title: Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography publication-title: Nat. Neurosci. doi: 10.1038/s41593-018-0195-0 – volume: 10 start-page: 203 year: 2018 ident: B28 article-title: Neural intrinsic timescales in the macaque dorsal premotor cortex predict the strength of spatial response coding publication-title: iScience doi: 10.1016/j.isci.2018.11.033 – volume: 9 start-page: 856 year: 2008 ident: B95 article-title: Functional role of the supplementary and pre-supplementary motor areas publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2478 – volume-title: Reinforcement Learning: An Introduction year: 1998 ident: B122 – volume: 103 start-page: 2433 year: 2010 ident: B99 article-title: Differential temporal storage capacity in the baseline activity of neurons in macaque frontal eye field and area V4 publication-title: J. Neurophysiol. doi: 10.1152/jn.01066.2009 – volume: 30 start-page: 535 year: 2007 ident: B51 article-title: The neural basis of decision making publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.29.051605.113038 – volume: 5 start-page: ENEURO.0169-18.2018 year: 2018 ident: B80 article-title: Strategic and dynamic temporal weighting for perceptual decisions in humans and macaques publication-title: eNeuro doi: 10.1523/ENEURO.0169-18.2018 – volume: 114 start-page: 394 year: 2017 ident: B94 article-title: Stable population coding for working memory coexists with heterogeneous neural dynamics in prefrontal cortex publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1619449114 – year: 2020 ident: B118 article-title: Multiple timescales of neural dynamics and integration of task-relevant signals across cortex publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.2005993117 – volume: 27 start-page: 2078 year: 2017 ident: B48 article-title: Area-specific features of pyramidal neurons-a comparative study in mouse and rhesus monkey publication-title: Cereb. Cortex doi: 10.1093/cercor/bhw062 – volume: 69 start-page: 1204 year: 2011 ident: B34 article-title: Model-based influences on humans’ choices and striatal prediction errors publication-title: Neuron doi: 10.1016/j.neuron.2011.02.027 – volume: 5 start-page: e14472 year: 2016 ident: B117 article-title: A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging publication-title: eLife doi: 10.7554/eLife.14472 – volume: 16 start-page: 832 year: 2013 ident: B18 article-title: Opportunities and limitations of intrinsic functional connectivity MRI publication-title: Nat. Neurosci. doi: 10.1038/nn.3423 – volume: 9 start-page: e52460 year: 2020 ident: B55 article-title: Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network publication-title: eLife doi: 10.7554/eLife.52460 – volume: 101 start-page: 1368 year: 2004 ident: B135 article-title: Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0305337101 – volume: 91 start-page: 893 year: 2016 ident: B96 article-title: Efficient receptive field tiling in primate V1 publication-title: Neuron doi: 10.1016/j.neuron.2016.07.015 – volume: 487 start-page: 51 year: 2012 ident: B300 article-title: Neural population dynamics during reaching publication-title: Nature doi: 10.1038/nature11129 – volume: 33 start-page: 17385 year: 2013 ident: B61 article-title: Single-neuron mechanisms underlying cost-benefit analysis in frontal cortex publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2221-13.2013 – volume: 30 start-page: 4544 year: 2020 ident: B124 article-title: Changes in the proportion of inhibitory interneuron types from sensory to executive areas of the primate neocortex: implications for the origins of working memory representations publication-title: Cereb. Cortex doi: 10.1093/cercor/bhaa056 – volume: 19 start-page: 394 year: 2015 ident: B120 article-title: “Activity-silent” working memory in prefrontal cortex: a dynamic coding framework publication-title: Trends Cogn. Sci. doi: 10.1016/j.tics.2015.05.004 – volume: 99 start-page: 598.e4 year: 2018 ident: B87 article-title: Volatility facilitates value updating in the prefrontal cortex publication-title: Neuron doi: 10.1016/j.neuron.2018.06.033 – volume: 497 start-page: 585 year: 2013 ident: B106 article-title: The importance of mixed selectivity in complex cognitive tasks publication-title: Nature doi: 10.1038/nature12160 – volume: 8 start-page: 1942 year: 2017 ident: B88 article-title: Simultaneous representation of a spectrum of dynamically changing value estimates during decision making publication-title: Nat. Commun. doi: 10.1038/s41467-017-02169-w – volume: 9 start-page: e53664 year: 2020 ident: B21 article-title: A circuit mechanism for decision-making biases and NMDA receptor hypofunction publication-title: eLife doi: 10.7554/eLife.53664 – volume: 19 start-page: 304 year: 2015 ident: B57 article-title: Hierarchical process memory: memory as an integral component of information processing publication-title: Trends Cogn. Sci. doi: 10.1016/j.tics.2015.04.006 – volume: 5 start-page: e12112 year: 2016 ident: B97 article-title: The hierarchical organization of the lateral prefrontal cortex publication-title: eLife doi: 10.7554/eLife.12112 – ident: B31 – volume: 12 start-page: 1317 year: 2009 ident: B10 article-title: Coding of stimulus sequences by population responses in visual cortex publication-title: Nat. Neurosci. doi: 10.1038/nn.2398 – volume: 411 start-page: 953 year: 2001 ident: B127 article-title: Single neurons in prefrontal cortex encode abstract rules publication-title: Nature doi: 10.1038/35082081 – volume: 3 start-page: e01239 year: 2014 ident: B25 article-title: A diversity of localized timescales in network activity publication-title: eLife doi: 10.7554/eLife.01239 – volume: 27 start-page: 8366 year: 2007 ident: B112 article-title: Temporal filtering of reward signals in the dorsal anterior cingulate cortex during a mixed-strategy game publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2369-07.2007 – volume: 4 start-page: 880 year: 1984 ident: B12 article-title: Physiological organization of layer 4 in macaque striate cortex publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.04-03-00880.1984 – volume: 169 start-page: 1013.e14 year: 2017 ident: B24 article-title: The code for facial identity in the primate brain publication-title: Cell doi: 10.1016/j.cell.2017.05.011 – volume: 19 start-page: 109 year: 1996 ident: B123 article-title: Inferotemporal cortex and object vision publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.ne.19.030196.000545 – volume: 13 start-page: 1292 year: 2010 ident: B74 article-title: Visual fixations and the computation and comparison of value in simple choice publication-title: Nat. Neurosci. doi: 10.1038/nn.2635 – volume: 399 start-page: 470 year: 1999 ident: B107 article-title: Neuronal correlates of parametric working memory in the prefrontal cortex publication-title: Nature doi: 10.1038/20939 – volume: 484 start-page: 62 year: 2012 ident: B56 article-title: Choice-specific sequences in parietal cortex during a virtual-navigation decision task publication-title: Nature doi: 10.1038/nature10918 – volume: 76 start-page: 838 year: 2012 ident: B20 article-title: Synchronous oscillatory neural ensembles for rules in the prefrontal cortex publication-title: Neuron doi: 10.1016/j.neuron.2012.09.029 – volume: 31 start-page: 2906 year: 2011 ident: B79 article-title: Topographic mapping of a hierarchy of temporal receptive windows using a narrated story publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3684-10.2011 – volume: 349 start-page: 184 year: 2015 ident: B76 article-title: NEURONAL MODELING. Single-trial spike trains in parietal cortex reveal discrete steps during decision-making publication-title: Science doi: 10.1126/science.aaa4056 – volume: 95 start-page: 709.e5 year: 2017 ident: B4 article-title: Discovering event structure in continuous narrative perception and memory publication-title: Neuron doi: 10.1016/j.neuron.2017.06.041 – volume: 115 start-page: 1117 year: 2018 ident: B7 article-title: Laminar recordings in frontal cortex suggest distinct layers for maintenance and control of working memory publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1710323115 – year: 2020 ident: B44 article-title: Local inhibitory control of frontal network metastability underlies the temporal signature of cognitive states publication-title: bioRxiv doi: 10.1101/2020.08.20.259192 – volume: 13 start-page: 1124 year: 2003 ident: B38 article-title: Cortex, cognition and the cell: new insights into the pyramidal neuron and prefrontal function publication-title: Cereb. Cortex doi: 10.1093/cercor/bhg093 – volume: 76 start-page: 423 year: 2012 ident: B60 article-title: Slow cortical dynamics and the accumulation of information over long timescales publication-title: Neuron doi: 10.1016/j.neuron.2012.08.011 – volume: 17 start-page: 1784 year: 2014 ident: B105 article-title: A category-free neural population supports evolving demands during decision-making publication-title: Nat. Neurosci. doi: 10.1038/nn.3865 – volume: 14 start-page: 477 year: 1995 ident: B53 article-title: Cellular basis of working memory publication-title: Neuron doi: 10.1016/0896-6273(95)90304-6 – volume: 24 start-page: 17 ident: B84 article-title: A weighted and directed interareal connectivity matrix for macaque cerebral cortex publication-title: Cereb. Cortex doi: 10.1093/cercor/bhs270 – volume: 110 start-page: 2019 year: 2013 ident: B119 article-title: A place for time: the spatiotemporal structure of neural dynamics during natural audition publication-title: J. Neurophysiol. doi: 10.1152/jn.00268.2013 – volume: 18 start-page: 172 year: 2017 ident: B64 article-title: A distributed, hierarchical and recurrent framework for reward-based choice publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn.2017.7 – volume: 359 start-page: 131 year: 1995 ident: B75 article-title: Intrinsic circuit organization of the major layers and sublayers of the dorsolateral prefrontal cortex in the rhesus monkey publication-title: J. Comp. Neurol. doi: 10.1002/cne.903590109 – volume: 522 start-page: 225 ident: B85 article-title: Anatomy of hierarchy: feedforward and feedback pathways in macaque visual cortex publication-title: J. Comp. Neurol. doi: 10.1002/cne.23458 – volume: 37 start-page: 66 year: 2016 ident: B46 article-title: Why neurons mix: high dimensionality for higher cognition publication-title: Curr. Opin. Neurobiol. doi: 10.1016/j.conb.2016.01.010 – volume: 14 start-page: 366 year: 2011 ident: B11 article-title: A reservoir of time constants for memory traces in cortical neurons publication-title: Nat. Neurosci. doi: 10.1038/nn.2752 – volume: 61 start-page: 331 year: 1989 ident: B45 article-title: Mnemonic coding of visual space in the monkey’s dorsolateral prefrontal cortex publication-title: J. Neurophysiol. doi: 10.1152/jn.1989.61.2.331 – volume: 38 start-page: 7013 year: 2018 ident: B81 article-title: Working memory: delay activity, yes! persistent activity? Maybe not publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2485-17.2018 – volume: 7 start-page: 880 year: 2004 ident: B14 article-title: Underlying principles of visual shape selectivity in posterior inferotemporal cortex publication-title: Nat. Neurosci. doi: 10.1038/nn1278 – volume: 23 start-page: 981 year: 2013 ident: B100 article-title: The timescale of perceptual evidence integration can be adapted to the environment publication-title: Curr. Biol. doi: 10.1016/j.cub.2013.04.039 – volume: 80 start-page: 791 year: 2013 ident: B113 article-title: Decision making as a window on cognition publication-title: Neuron doi: 10.1016/j.neuron.2013.10.047 – volume: 17 start-page: 1661 year: 2014 ident: B93 article-title: A hierarchy of intrinsic timescales across primate cortex publication-title: Nat. Neurosci. doi: 10.1038/nn.3862 – volume: 103 start-page: 1178.e7 year: 2019 ident: B138 article-title: Neural organization of hierarchical motor sequence representations in the human neocortex publication-title: Neuron doi: 10.1016/j.neuron.2019.06.017 – volume: 195 start-page: 215 year: 1968 ident: B63 article-title: Receptive fields and functional architecture of monkey striate cortex publication-title: J. Physiol. doi: 10.1113/jphysiol.1968.sp008455 – volume: 79 start-page: 555 year: 1998 ident: B125 article-title: Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors publication-title: J. Neurophysiol. doi: 10.1152/jn.1998.79.2.555 – volume: 5 start-page: 2 year: 2011 ident: B39 article-title: Pyramidal cells in prefrontal cortex of primates: marked differences in neuronal structure among species publication-title: Front. Neuroanat. doi: 10.3389/fnana.2011.00002 – volume: 5 start-page: e18937 year: 2016 ident: B23 article-title: Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice publication-title: eLife doi: 10.7554/eLife.18937 – volume: 101 start-page: 1181.e13 year: 2019 ident: B35 article-title: Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics publication-title: Neuron doi: 10.1016/j.neuron.2019.01.017 – volume: 27 start-page: 889 year: 1998 ident: B78 article-title: Single units and visual cortical organization publication-title: Perception doi: 10.1068/p270889 – volume: 12 start-page: 193 year: 2008 ident: B3 article-title: Cognitive control, hierarchy, and the rostro-caudal organization of the frontal lobes publication-title: Trends Cogn. Sci. doi: 10.1016/j.tics.2008.02.004 – volume: 105 start-page: 16791 year: 2008 ident: B128 article-title: A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0804318105 – volume: 3 start-page: 1138 year: 1992 ident: B137 article-title: Developmental changes in distribution of NMDA receptor channel subunit mRNAs publication-title: NeuroReport doi: 10.1097/00001756-199212000-00027 – volume: 22 start-page: 1687 year: 2019 ident: B43 article-title: Layer-dependent activity in human prefrontal cortex during working memory publication-title: Nat. Neurosci. doi: 10.1038/s41593-019-0487-z – volume: 146 start-page: 1082 year: 2007 ident: B114 article-title: Variability in neuronal activity in primate cortex during working memory tasks publication-title: Neuroscience doi: 10.1016/j.neuroscience.2006.12.072 – volume: 38 start-page: 7020 year: 2018 ident: B30 article-title: Persistent spiking activity underlies working memory publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2486-17.2018 – volume: 38 start-page: 9689 year: 2018 ident: B5 article-title: Representation of real-world event schemas during narrative perception publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0251-18.2018 – volume: 61 start-page: 621 year: 2009 ident: B52 article-title: Memory without feedback in a neural network publication-title: Neuron doi: 10.1016/j.neuron.2008.12.012 – volume: 19 start-page: 1672 year: 2016 ident: B92 article-title: History-dependent variability in population dynamics during evidence accumulation in cortex publication-title: Nat. Neurosci. doi: 10.1038/nn.4403 – volume: 113 start-page: 262 year: 2009 ident: B13 article-title: Hierarchically organized behavior and its neural foundations: a reinforcement learning perspective publication-title: Cognition doi: 10.1016/j.cognition.2008.08.011 – volume: 85 start-page: 390 year: 2015 ident: B8 article-title: Visual areas exert feedforward and feedback influences through distinct frequency channels publication-title: Neuron doi: 10.1016/j.neuron.2014.12.018 – volume: 160 start-page: 106 year: 1962 ident: B62 article-title: Receptive fields, binocular interaction and functional architecture in the cat’s visual cortex publication-title: J. Physiol. doi: 10.1113/jphysiol.1962.sp006837 – volume: 548 start-page: 92 year: 2017 ident: B108 article-title: Distinct timescales of population coding across cortex publication-title: Nature doi: 10.1038/nature23020 – volume: 28 start-page: 2539 year: 2008 ident: B58 article-title: A hierarchy of temporal receptive windows in human cortex publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5487-07.2008 – volume: 24 start-page: 455 year: 2001 ident: B132 article-title: Synaptic reverberation underlying mnemonic persistent activity publication-title: Trends Neurosci. doi: 10.1016/s0166-2236(00)01868-3 – volume: 311 start-page: 463 year: 1991 ident: B82 article-title: Multiple representations of body movements in mesial area 6 and the adjacent cingulate cortex: an intracortical microstimulation study in the macaque monkey publication-title: J. Comp. Neurol. doi: 10.1002/cne.903110403 – volume: 19 start-page: 2209 year: 1999 ident: B2 article-title: Cellular mechanisms contributing to response variability of cortical neurons in vivo publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.19-06-02209.1999 – volume: 518 start-page: 399 year: 2015 ident: B32 article-title: Functional organization of excitatory synaptic strength in primary visual cortex publication-title: Nature doi: 10.1038/nature14182 – volume: 70 start-page: 216 year: 1988 ident: B50 article-title: Memory related motor planning activity in posterior parietal cortex of macaque publication-title: Exp. Brain Res. doi: 10.1007/BF00271862
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SubjectTerms	Animals autocorrelation Brain - physiology Brain research Cerebral Cortex - physiology Cognitive ability Computational neuroscience Decision making Electrophysiology Humans Information processing Listening Medical imaging Memory, Short-Term - physiology Nerve Net - physiology Neural networks Neural Pathways - physiology Neuroimaging neuronal timescale Neurons Neurons - physiology Neuroscience Short term memory time constant working memory
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Title	A Diversity of Intrinsic Timescales Underlie Neural Computations
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