Glioblastoma of the cerebellum and brainstem

Glioblastoma multiforme (GB) is the most common and most malignant primary intracranial tumor. Of the 577 patients who underwent surgery for newly diagnosed GB (World Health Organization grade IV) between January 1991 and March 2008 at our department, seven had infratentorial GB (iGB) (incidence 1.2...

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Bibliographic Details
Published in:Journal of clinical neuroscience Vol. 17; no. 10; pp. 1248 - 1251
Main Authors: Stark, Andreas Martin, Maslehaty, Homajoun, Hugo, Heinz Hermann, Mahvash, Mehran, Mehdorn, Hubertus Maximilian
Format: Journal Article
Language:English
Published: Scotland Elsevier Ltd 01.10.2010
Subjects:
Adjuvants
Adult
Aged
Aged, 80 and over
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Brain Stem - pathology
Brain Stem - surgery
Brainstem glioma
Cerebellum - pathology
Cerebellum - surgery
Cerebellum glioma
Female
Glioblastoma - pathology
Glioblastoma - surgery
Glioblastoma multiforme
Humans
Infratentorial glioblastoma
Magnetic Resonance Imaging - methods
Male
Middle Aged
Neurology
Retrospective Studies
Young Adult
Infratentorial glioblastoma
Brainstem glioma
Cerebellum glioma
Glioblastoma multiforme
ISSN:0967-5868, 1532-2653, 1532-2653
Online Access:Get full text
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Summary:Glioblastoma multiforme (GB) is the most common and most malignant primary intracranial tumor. Of the 577 patients who underwent surgery for newly diagnosed GB (World Health Organization grade IV) between January 1991 and March 2008 at our department, seven had infratentorial GB (iGB) (incidence 1.2%). Patients younger than 21 years of age, as well as patients with gliomatosis cerebri, were excluded from the analysis. We concluded that iGB is rare in adults. Because of its rarity and the non-specific radiological features of iGB, it can easily be misdiagnosed as a brain metastasis, ependymoma or even as a benign lesion such as vestibular schwannoma or meningioma. Surgical removal, or at least stereotactic biopsy, is essential to establish the diagnosis. Postoperative adjuvant therapy similar to that for supratentorial glioblastoma is indicated. We analysed the clinical characteristics and therapy of our patients with iGB and reviewed the literature.
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ISSN:0967-5868
1532-2653
1532-2653
DOI:10.1016/j.jocn.2010.02.015