14-3-3: A Case Study in PPI Modulation

In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for p...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 23; no. 6; p. 1386
Main Authors: Ballone, Alice, Centorrino, Federica, Ottmann, Christian
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 08.06.2018
MDPI
Subjects:
14-3-3 PPIs
14-3-3 Proteins - metabolism
14-3-3 Proteins - physiology
Amino acids
Binding sites
Bioinformatics
Case studies
Cell adhesion & migration
Cell cycle
Crystallography
Humans
Ligands
Pathogenesis
Peptides
Physiology
PPI modulation
Protein Interaction Maps - physiology
Proteins
Regulation
Review
Signal transduction
small molecules
small molecules
14-3-3 PPIs
PPI modulation
ISSN:1420-3049, 1420-3049
Online Access:Get full text
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Summary:In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for pharmacological intervention in human diseases, such as cancer and neurodegenerative and metabolic disorders. This viewpoint is built on the “hub” nature of the 14-3-3 proteins, binding to several hundred identified partners, consequently implicating them in a multitude of different cellular mechanisms. In this review, we provide an overview of the structural and biological features of 14-3-3 and the modulation of 14-3-3 PPIs for discovering small molecular inhibitors and stabilizers of 14-3-3 PPIs.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23061386