Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets

The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread brain regions, and projects throughout the forebrain, brainstem, cerebellum, and spinal cord. LC neurons release NE to control arou...

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Vydáno v:Frontiers in neural circuits Ročník 15; s. 638007
Hlavní autoři: Breton-Provencher, Vincent, Drummond, Gabrielle T., Sur, Mriganka
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Research Foundation 07.06.2021
Frontiers Media S.A
Témata:
Alzheimer's disease
Arousal
Behavior
Brain
Brain stem
Cerebellum
Dopamine
Experiments
Forebrain
Hypothalamus
inhibition
learning
Locus Coeruleus
Neural Circuits
Neuromodulation
Neurons
Neuropeptides
noradrenaline (norepinephrine)
Norepinephrine
Rabies
Spinal cord
neuromodulation
noradrenaline (norepinephrine)
learned behavior
inhibition
learning
locus coeruleus
arousal
ISSN:1662-5110, 1662-5110
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Popis
Shrnutí:The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread brain regions, and projects throughout the forebrain, brainstem, cerebellum, and spinal cord. LC neurons release NE to control arousal, but also in the context of a variety of sensory-motor and behavioral functions. Despite its brain-wide effects, much about the role of LC-NE in behavior and the circuits controlling LC activity is unknown. New evidence suggests that the modular input-output organization of the LC could enable transient, task-specific modulation of distinct brain regions. Future work must further assess whether this spatial modularity coincides with functional differences in LC-NE subpopulations acting at specific times, and how such spatiotemporal specificity might influence learned behaviors. Here, we summarize the state of the field and present new ideas on the role of LC-NE in learned behaviors.
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These authors have contributed equally to this work
Reviewed by: Ying Zhang, Dalhousie University, Canada; Tianyi Mao, Oregon Health & Science University, United States
Edited by: Tommaso Pizzorusso, University of Florence, Italy
ISSN:1662-5110
1662-5110
DOI:10.3389/fncir.2021.638007