Photoprotective Effect of Dietary Galacto-Oligosaccharide (GOS) in Hairless Mice via Regulation of the MAPK Signaling Pathway

This study investigated the suppression of photoaging by galacto-oligosaccharide (GOS) ingestion following exposure to ultraviolet (UV) radiation. To investigate its photoprotective effects, GOS along with collagen tripeptide (CTP) as a positive control was orally administered to hairless mice under...

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Vydané v:Molecules (Basel, Switzerland) Ročník 25; číslo 7; s. 1679
Hlavní autori: Suh, Min Geun, Bae, Gi Yeon, Jo, Kyungae, Kim, Jin Man, Hong, Ki-Bae, Suh, Hyung Joo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 06.04.2020
MDPI
Predmet:
Animals
Collagen
Cytokines
Dermatitis
galacto-oligosaccharide
Homeostasis
MAP Kinase Signaling System - drug effects
MAP Kinase Signaling System - genetics
MAP Kinase Signaling System - physiology
MAPK
Matrix Metalloproteinases - genetics
Matrix Metalloproteinases - metabolism
Mice
Mice, Hairless
Microorganisms
MMP
Oligosaccharides - pharmacology
Prebiotics
Probiotics
Signal Transduction - drug effects
Signal Transduction - genetics
Skin
Skin Aging - radiation effects
Skin diseases
TEWL
Ultraviolet radiation
Ultraviolet Rays
galacto-oligosaccharide
MMP
TEWL
MAPK
ISSN:1420-3049, 1420-3049
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Shrnutí:This study investigated the suppression of photoaging by galacto-oligosaccharide (GOS) ingestion following exposure to ultraviolet (UV) radiation. To investigate its photoprotective effects, GOS along with collagen tripeptide (CTP) as a positive control was orally administered to hairless mice under UVB exposure for 8 weeks. The water holding capacity, transepidermal water loss (TEWL), and wrinkle parameters were measured. Additionally, quantitative reverse-transcription polymerase chain reaction and Western blotting were used to determine mRNA expression and protein levels, respectively. The GOS or CTP orally-administered group showed a decreased water holding capacity and increased TEWL compared to those of the control group, which was exposed to UVB (CON) only. In addition, the wrinkle area and mean wrinkle length in the GOS and CTP groups significantly decreased. Skin aging-related genes, matrix metalloproteinase, had significantly different expression levels in the CTP and GOS groups. Additionally, the tissue inhibitor of metalloproteinases and collagen type I gene expression in the CTP and GOS groups significantly increased. Oral administration of GOS and CTP significantly lowered the tissue cytokine (interleukin-6 and -12, and tumor necrosis factor-α) levels. There was a significant difference in UVB-induced phosphorylation of JNK, p38, and ERK between the GOS group and the CON group. Our findings indicate that GOS intake can suppress skin damage caused by UV light and has a UV photoprotective effect.
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These authors contribute equally to the work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25071679