A proof of principle investigation of a novel enzyme formulation on dental calculus deposition: a 4-week randomized human clinical trial

Background The dissolution of dental calculus, safely and at home, is among the more challenging issues facing the over-the-counter healthcare industry. Pontis Biologics, Inc. has developed novel model of calculus development and structure and has formulated a dentifrice (Tartarase™) using digestive...

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Bibliographic Details
Published in:	BMC oral health Vol. 24; no. 1; pp. 720 - 8
Main Authors:	Milleman, Kimberly R., Deener, Greg, Milleman, Jeffery L., Mish, Barbara, Schuller, Reinhard, Mynarcik, Dennis
Format:	Journal Article
Language:	English
Published:	London BioMed Central 22.06.2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adult Adverse Biofilms Brushing Calculus Cardiovascular disease Care and treatment Clinical trials Control Dental calculus Dental Calculus - prevention & control Dental caries Dental plaque Dentifrices - therapeutic use Dentistry Diabetes Diagnosis Digestive enzymes Disease prevention Enzymes Female Fluorides Health aspects Humans Hygiene Identification and classification Male Medicine Microbial mats Middle Aged Mouth diseases Oral and Maxillofacial Surgery Oral diseases Oral hygiene Proof of Concept Study Safety Teeth Toothbrushing Toothpaste Volpe-Manhold Index (V-MI) Canada United States > US Enzymes Volpe-Manhold Index (V-MI) Formulation Brushing Calculus Adverse Safety
ISSN:	1472-6831, 1472-6831
Online Access:	Get full text
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