Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Tumour cells evade immune surveillance by upregulating the surface expression of programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) receptor on T cells to elicit the immune checkpoint response 1 , 2 . Anti-PD-1 antibodies have shown remarkable promise in treating tumou...

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Bibliographic Details
Published in:	Nature (London) Vol. 560; no. 7718; pp. 382 - 386
Main Authors:	Chen, Gang, Huang, Alexander C., Zhang, Wei, Zhang, Gao, Wu, Min, Xu, Wei, Yu, Zili, Yang, Jiegang, Wang, Beike, Sun, Honghong, Xia, Houfu, Man, Qiwen, Zhong, Wenqun, Antelo, Leonardo F., Wu, Bin, Xiong, Xuepeng, Liu, Xiaoming, Guan, Lei, Li, Ting, Liu, Shujing, Yang, Ruifeng, Lu, Youtao, Dong, Liyun, McGettigan, Suzanne, Somasundaram, Rajasekharan, Radhakrishnan, Ravi, Mills, Gordon, Lu, Yiling, Kim, Junhyong, Chen, Youhai H., Dong, Haidong, Zhao, Yifang, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Herlyn, Meenhard, Wherry, E. John, Xu, Xiaowei, Guo, Wei
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.08.2018 Nature Publishing Group
Subjects:	13 13/106 13/109 13/21 13/31 13/51 13/89 14 14/19 14/28 49 49/79 631/67/580 64/60 692/699/67/1813/1634 Animals Antibodies Antibodies, Monoclonal, Humanized - pharmacology Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use Apoptosis B7-H1 Antigen - blood B7-H1 Antigen - immunology B7-H1 Antigen - metabolism Biological response modifiers Cancer metastasis Cancer therapies Case-Control Studies CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Death Disease Progression Exosomes Exosomes - metabolism Female Head & neck cancer Humanities and Social Sciences Humans Immune checkpoint Immune system Immune Tolerance - drug effects Immune Tolerance - immunology Immunoglobulins Immunosuppression Immunosurveillance Immunotherapy Intelligence gathering Interferon Interferon-gamma - blood Interferon-gamma - immunology Letter Ligands Lymphocytes Lymphocytes T Medical research Medical schools Melanoma Melanoma - drug therapy Melanoma - immunology Melanoma - pathology Metastases Metastasis Mice Mice, Nude Microscopy multidisciplinary Neoplasm Metastasis Patient monitoring equipment Patients PD-1 protein PD-L1 protein Prognosis Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Properties Proteins Science Science (multidisciplinary) Skin cancer T cell receptors T cells Therapy Tumor Escape - drug effects Tumor Escape - immunology Tumors Vesicles Xenograft Model Antitumor Assays
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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