Macrophage development from HSCs requires PU.1-coordinated microRNA expression

The differentiation of HSCs into myeloid lineages requires the transcription factor PU.1. Whereas PU.1-dependent induction of myeloid-specific target genes has been intensively studied, negative regulation of stem cell or alternate lineage programs remains incompletely characterized. To test for suc...

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Vydané v:	Blood Ročník 118; číslo 8; s. 2275
Hlavní autori:	Ghani, Saeed, Riemke, Pia, Schönheit, Jörg, Lenze, Dido, Stumm, Jürgen, Hoogenkamp, Maarten, Lagendijk, Anne, Heinz, Sven, Bonifer, Constanze, Bakkers, Jeroen, Abdelilah-Seyfried, Salim, Hummel, Michael, Rosenbauer, Frank
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 25.08.2011
Predmet:	Animals Cell Differentiation - genetics Cell Line Cell Lineage - genetics Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism In Vitro Techniques Macrophages, Peritoneal - cytology Macrophages, Peritoneal - metabolism Mice Mice, Inbred C57BL MicroRNAs - genetics Myelopoiesis - genetics Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics RNA, Small Interfering - genetics Trans-Activators - antagonists & inhibitors Trans-Activators - genetics Zebrafish - embryology Zebrafish - genetics
ISSN:	1528-0020, 1528-0020
On-line prístup:	Zistit podrobnosti o prístupe
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