Macrophage development from HSCs requires PU.1-coordinated microRNA expression

The differentiation of HSCs into myeloid lineages requires the transcription factor PU.1. Whereas PU.1-dependent induction of myeloid-specific target genes has been intensively studied, negative regulation of stem cell or alternate lineage programs remains incompletely characterized. To test for suc...

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Bibliographic Details
Published in:	Blood Vol. 118; no. 8; p. 2275
Main Authors:	Ghani, Saeed, Riemke, Pia, Schönheit, Jörg, Lenze, Dido, Stumm, Jürgen, Hoogenkamp, Maarten, Lagendijk, Anne, Heinz, Sven, Bonifer, Constanze, Bakkers, Jeroen, Abdelilah-Seyfried, Salim, Hummel, Michael, Rosenbauer, Frank
Format:	Journal Article
Language:	English
Published:	United States 25.08.2011
Subjects:	Animals Cell Differentiation - genetics Cell Line Cell Lineage - genetics Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism In Vitro Techniques Macrophages, Peritoneal - cytology Macrophages, Peritoneal - metabolism Mice Mice, Inbred C57BL MicroRNAs - genetics Myelopoiesis - genetics Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics RNA, Small Interfering - genetics Trans-Activators - antagonists & inhibitors Trans-Activators - genetics Zebrafish - embryology Zebrafish - genetics
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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