Persistent arthralgia among Chikungunya patients and associated risk factors in Chennai, South India

Context: Chikungunya (CHIK) fever is viral disease characterized by joint pain for prolonged duration in various settings. However, there are no reports of long-term follow-up of the CHIK patients from India. Aims: We conducted a cohort study to describe the clinical manifestations, incidence of per...

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Vydané v:Journal of postgraduate medicine Ročník 60; číslo 1; s. 3 - 6
Hlavní autori: Ramachandran, V, Kaur, P, Kanagasabai, K, Vadivoo, S, Murhekar, MV
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: India Wolters Kluwer - Medknow 2014
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Vydanie:2
Predmet:
Adolescent
Adult
Aged
Ankle Joint
Arthralgia
Arthralgia - complications
Arthralgia - epidemiology
Arthralgia - virology
Case-Control Studies
Chikungunya fever
Chikungunya Fever - complications
Chikungunya Fever - epidemiology
Chikungunya Fever - virology
Cohort analysis
Complications and side effects
Diagnosis
Disease Outbreaks
Distribution
Female
Fever - etiology
Health risks
Humans
Incidence
India - epidemiology
Knee Joint
Male
Middle Aged
Original Article
Prospective Studies
Retrospective Studies
Risk Factors
Socioeconomic Factors
Surveys and Questionnaires
Wrist Joint
Young Adult
India
Chikungunya
Arthralgia
India
ISSN:0022-3859, 0972-2823, 0972-2823
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Shrnutí:Context: Chikungunya (CHIK) fever is viral disease characterized by joint pain for prolonged duration in various settings. However, there are no reports of long-term follow-up of the CHIK patients from India. Aims: We conducted a cohort study to describe the clinical manifestations, incidence of persistent arthralgia, and the associated risk factors among patients with CHIK identified during an outbreak in a suburb of Chennai, India. Materials and Methods: We conducted a retrospective cum prospective cohort study in Gowripet, Avadi, Chennai. We included all adult CHIK case patients identified during the outbreak. We conducted a nested case-control study to identify the risk factors for persistent arthralgia defined as a CHIK case experiencing arthralgia for more than 15 days from the date of onset of illness. We included all 81 patients and 81 randomly selected controls. Results: All 403 case patients had joint pain. Approximately 40% suffered joint pain for up to 1 month and 7% had it beyond 1 year. The most commonly affected types of joints were knee (96%), wrist (80%), and ankle (77%) joints. Regarding the number of types of joints affected, 36% had six types of joints, 23% had five types of joints, and 14% had three types of joints affected. The overall incidence of persistent arthralgia was 80%. High-grade fever, involvement of four or more types of joints, and joint swelling were significantly associated with persistent arthralgia. Conclusions: High prevalence of persistent arthralgia indicates the need for appropriate treatment strategies to reduce the severity and duration of joint pain.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-3859
0972-2823
0972-2823
DOI:10.4103/0022-3859.128795