Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis

Suppression of M current channels by muscarinic receptors enhances neuronal excitability. Little is known about the molecular mechanism of this inhibition except the requirement for a specific G protein and the involvement of an unidentified diffusible second messenger. We demonstrate here that intr...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 35; no. 3; p. 507
Main Authors:	Suh, Byung-Chang, Hille, Bertil
Format:	Journal Article
Language:	English
Published:	United States 01.08.2002
Subjects:	1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors 1-Phosphatidylinositol 4-Kinase - metabolism Adenosine Diphosphate - metabolism Adenosine Diphosphate - pharmacology Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animals Cells, Cultured Enzyme Inhibitors - pharmacology Glucose - metabolism Glucose - pharmacology GTP-Binding Proteins - drug effects GTP-Binding Proteins - metabolism KCNQ2 Potassium Channel KCNQ3 Potassium Channel Male Membrane Potentials - drug effects Membrane Potentials - physiology Muscarinic Agonists - pharmacology Neural Inhibition - drug effects Neural Inhibition - physiology Neurons - cytology Neurons - drug effects Neurons - metabolism Phosphatidylinositol 4,5-Diphosphate - biosynthesis Phosphorylation Potassium Channels - drug effects Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Voltage-Gated Rats Rats, Sprague-Dawley Receptors, Muscarinic - drug effects Receptors, Muscarinic - metabolism Superior Cervical Ganglion - cytology Superior Cervical Ganglion - drug effects Superior Cervical Ganglion - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Type C Phospholipases - antagonists & inhibitors Type C Phospholipases - metabolism
ISSN:	0896-6273
Online Access:	Get more information
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