In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease

Following acute infection, herpes simplex virus (HSV) establishes latency in sensory neurons, from which it can reactivate and cause recurrent disease. Available antiviral therapies do not affect latent viral genomes; therefore, they do not prevent reactivation following therapy cessation. One possi...

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Vydané v:	Molecular therapy. Nucleic acids Ročník 3; číslo 2; s. e146
Hlavní autori:	Aubert, Martine, Boyle, Nicole M, Stone, Daniel, Stensland, Laurence, Huang, Meei-Li, Magaret, Amalia S, Galetto, Roman, Rawlings, David J, Scharenberg, Andrew M, Jerome, Keith R
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.02.2014 Elsevier Limited Nature Publishing Group Elsevier
Predmet:	Adeno-associated virus antiviral endonuclease Herpes simplex virus 1 mutagenesis Original endonuclease mutagenesis antiviral
ISSN:	2162-2531, 2162-2531
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