In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease

Following acute infection, herpes simplex virus (HSV) establishes latency in sensory neurons, from which it can reactivate and cause recurrent disease. Available antiviral therapies do not affect latent viral genomes; therefore, they do not prevent reactivation following therapy cessation. One possi...

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Bibliographic Details

Published in:	Molecular therapy. Nucleic acids Vol. 3; no. 2; p. e146
Main Authors:	Aubert, Martine, Boyle, Nicole M, Stone, Daniel, Stensland, Laurence, Huang, Meei-Li, Magaret, Amalia S, Galetto, Roman, Rawlings, David J, Scharenberg, Andrew M, Jerome, Keith R
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2014 Elsevier Limited Nature Publishing Group Elsevier
Subjects:	Adeno-associated virus antiviral endonuclease Herpes simplex virus 1 mutagenesis Original endonuclease mutagenesis antiviral
ISSN:	2162-2531, 2162-2531
Online Access:	Get full text
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