In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease

Following acute infection, herpes simplex virus (HSV) establishes latency in sensory neurons, from which it can reactivate and cause recurrent disease. Available antiviral therapies do not affect latent viral genomes; therefore, they do not prevent reactivation following therapy cessation. One possi...

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Veröffentlicht in:	Molecular therapy. Nucleic acids Jg. 3; H. 2; S. e146
Hauptverfasser:	Aubert, Martine, Boyle, Nicole M, Stone, Daniel, Stensland, Laurence, Huang, Meei-Li, Magaret, Amalia S, Galetto, Roman, Rawlings, David J, Scharenberg, Andrew M, Jerome, Keith R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.02.2014 Elsevier Limited Nature Publishing Group Elsevier
Schlagworte:	Adeno-associated virus antiviral endonuclease Herpes simplex virus 1 mutagenesis Original endonuclease mutagenesis antiviral
ISSN:	2162-2531, 2162-2531
Online-Zugang:	Volltext
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