Recent advances in biotechnological production of 2-phenylethanol

2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries and is mainly produced by chemical synthesis. An alternative method for the production of natural flavors and fragrances is the microbial trans...

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Vydané v:	Biotechnology advances Ročník 29; číslo 6; s. 654 - 660
Hlavní autori:	Hua, Dongliang, Xu, Ping
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Kidlington Elsevier Inc 01.11.2011 Elsevier
Predmet:	2-phenylethanol Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotechnology - methods Biotransformation Ehrlich pathway flavor food industry Fundamental and applied biological sciences. Psychology In situ product removal industrialization Kluyveromyces - metabolism l-phenylalanine Methods. Procedures. Technologies odors perfumes phenylalanine Phenylalanine - metabolism phenylethyl alcohol Phenylethyl Alcohol - metabolism Saccharomyces cerevisiae - metabolism synthesis 2-phenylethanol Ehrlich pathway In situ product removal l-phenylalanine Biotransformation Biotechnology L-phenylalanine Phenylalanine In situ Production
ISSN:	0734-9750, 1873-1899, 1873-1899
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Abstract	2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries and is mainly produced by chemical synthesis. An alternative method for the production of natural flavors and fragrances is the microbial transformation process, which is attracting increasing attention because it is an environmentally friendly process and the products are considered “natural”. The production of 2-PE from L-phenylalanine by biotransformation is possible through the Ehrlich pathway and considerable progress has been made in the development of this process. The present report reviews recent advances in biotechnological production of 2-PE, with emphasis on the strategies used to increase production and the applications of in situ product removal techniques. Future research should focus on product scale-up and product recovery processes for the industrialization of microbial processes.
AbstractList	2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries and is mainly produced by chemical synthesis. An alternative method for the production of natural flavors and fragrances is the microbial transformation process, which is attracting increasing attention because it is an environmentally friendly process and the products are considered “natural”. The production of 2-PE from L-phenylalanine by biotransformation is possible through the Ehrlich pathway and considerable progress has been made in the development of this process. The present report reviews recent advances in biotechnological production of 2-PE, with emphasis on the strategies used to increase production and the applications of in situ product removal techniques. Future research should focus on product scale-up and product recovery processes for the industrialization of microbial processes. 2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries and is mainly produced by chemical synthesis. An alternative method for the production of natural flavors and fragrances is the microbial transformation process, which is attracting increasing attention because it is an environmentally friendly process and the products are considered "natural". The production of 2-PE from L-phenylalanine by biotransformation is possible through the Ehrlich pathway and considerable progress has been made in the development of this process. The present report reviews recent advances in biotechnological production of 2-PE, with emphasis on the strategies used to increase production and the applications of in situ product removal techniques. Future research should focus on product scale-up and product recovery processes for the industrialization of microbial processes.2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries and is mainly produced by chemical synthesis. An alternative method for the production of natural flavors and fragrances is the microbial transformation process, which is attracting increasing attention because it is an environmentally friendly process and the products are considered "natural". The production of 2-PE from L-phenylalanine by biotransformation is possible through the Ehrlich pathway and considerable progress has been made in the development of this process. The present report reviews recent advances in biotechnological production of 2-PE, with emphasis on the strategies used to increase production and the applications of in situ product removal techniques. Future research should focus on product scale-up and product recovery processes for the industrialization of microbial processes.
Author	Xu, Ping Hua, Dongliang
Author_xml	– sequence: 1 givenname: Dongliang surname: Hua fullname: Hua, Dongliang organization: State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240,People's Republic of China – sequence: 2 givenname: Ping surname: Xu fullname: Xu, Ping email: pingxu@sjtu.edu.cn organization: State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240,People's Republic of China
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Snippet	2-Phenylethanol (2-PE) is an important aromatic alcohol with a rose-like fragrance. It has been widely applied in the cosmetic, perfume, and food industries...
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SubjectTerms	2-phenylethanol Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotechnology - methods Biotransformation Ehrlich pathway flavor food industry Fundamental and applied biological sciences. Psychology In situ product removal industrialization Kluyveromyces - metabolism l-phenylalanine Methods. Procedures. Technologies odors perfumes phenylalanine Phenylalanine - metabolism phenylethyl alcohol Phenylethyl Alcohol - metabolism Saccharomyces cerevisiae - metabolism synthesis
Title	Recent advances in biotechnological production of 2-phenylethanol
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