LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery

Ceramides (CERs) in the upper layer of the skin, the stratum corneum (SC), play a key role in the skin barrier function. In human SC, the literature currently reports 11 CER subclasses that have been identified. In this paper, a novel quick and robust LC/MS method is presented that allows the separa...

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Vydané v:	Journal of lipid research Ročník 52; číslo 6; s. 1211 - 1221
Hlavní autori:	van Smeden, Jeroen, Hoppel, Louise, van der Heijden, Rob, Hankemeier, Thomas, Vreeken, Rob J, Bouwstra, Joke A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier 01.06.2011
Predmet:	Adult atmospheric pressure chemical ionization mass spectrometry Ceramides - analysis Ceramides - chemistry Ceramides - classification Ceramides - isolation & purification Chromatography, Liquid - methods human skin lipids Humans Lipid Metabolism - physiology liquid chromatography Male mass spectrometry Mass Spectrometry - methods normal-phase liquid chromatography Skin - chemistry Specimen Handling - methods Spectroscopy, Fourier Transform Infrared sphingolipids Tissue Culture Techniques
ISSN:	1539-7262, 0022-2275, 1539-7262
On-line prístup:	Získať plný text
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