LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery

Ceramides (CERs) in the upper layer of the skin, the stratum corneum (SC), play a key role in the skin barrier function. In human SC, the literature currently reports 11 CER subclasses that have been identified. In this paper, a novel quick and robust LC/MS method is presented that allows the separa...

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Veröffentlicht in:	Journal of lipid research Jg. 52; H. 6; S. 1211 - 1221
Hauptverfasser:	van Smeden, Jeroen, Hoppel, Louise, van der Heijden, Rob, Hankemeier, Thomas, Vreeken, Rob J, Bouwstra, Joke A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier 01.06.2011
Schlagworte:	Adult atmospheric pressure chemical ionization mass spectrometry Ceramides - analysis Ceramides - chemistry Ceramides - classification Ceramides - isolation & purification Chromatography, Liquid - methods human skin lipids Humans Lipid Metabolism - physiology liquid chromatography Male mass spectrometry Mass Spectrometry - methods normal-phase liquid chromatography Skin - chemistry Specimen Handling - methods Spectroscopy, Fourier Transform Infrared sphingolipids Tissue Culture Techniques
ISSN:	1539-7262, 0022-2275, 1539-7262
Online-Zugang:	Volltext
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