PML regulates apoptosis at endoplasmic reticulum by modulating calcium release

The promyelocytic leukemia (PML) tumor suppressor is a pleiotropic modulator of apoptosis. However, the molecular basis for such a diverse proapoptotic role is currently unknown. We show that extranuclear Pml was specifically enriched at the endoplasmic reticulum (ER) and at the mitochondria-associa...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 330; H. 6008; S. 1247
Hauptverfasser:	Giorgi, Carlotta, Ito, Keisuke, Lin, Hui-Kuan, Santangelo, Clara, Wieckowski, Mariusz R, Lebiedzinska, Magdalena, Bononi, Angela, Bonora, Massimo, Duszynski, Jerzy, Bernardi, Rosa, Rizzuto, Rosario, Tacchetti, Carlo, Pinton, Paolo, Pandolfi, Pier Paolo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 26.11.2010
Schlagworte:	Adenosine Triphosphate - metabolism Animals Apoptosis Calcium - metabolism Calcium Signaling Cell Line Cell Nucleus - metabolism Cells, Cultured Cytosol - metabolism Endoplasmic Reticulum - metabolism Homeostasis Humans Inositol 1,4,5-Trisphosphate - metabolism Inositol 1,4,5-Trisphosphate Receptors - metabolism Intracellular Membranes - metabolism Mice Mitochondria - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphorylation Promyelocytic Leukemia Protein Protein Phosphatase 2 - metabolism Proto-Oncogene Proteins c-akt - metabolism Recombinant Fusion Proteins - metabolism Stress, Physiological Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
ISSN:	1095-9203, 1095-9203
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