Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

The transcription factor PU.1 occupies a central role in controlling myeloid and early B-cell development, and its correct lineage-specific expression is critical for the differentiation choice of hematopoietic progenitors. However, little is known of how this tissue-specific pattern is established....

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Bibliographic Details
Published in:	Blood Vol. 117; no. 10; p. 2827
Main Authors:	Leddin, Mathias, Perrod, Chiara, Hoogenkamp, Maarten, Ghani, Saeed, Assi, Salam, Heinz, Sven, Wilson, Nicola K, Follows, George, Schönheit, Jörg, Vockentanz, Lena, Mosammam, Ali M, Chen, Wei, Tenen, Daniel G, Westhead, David R, Göttgens, Berthold, Bonifer, Constanze, Rosenbauer, Frank
Format:	Journal Article
Language:	English
Published:	United States 10.03.2011
Subjects:	Animals B-Lymphocytes - metabolism Blotting, Southern Blotting, Western Cell Separation Feedback, Physiological - physiology Flow Cytometry Gene Expression Gene Expression Regulation - genetics Hematopoiesis - genetics Humans Mice Mice, Transgenic Myeloid Cells - metabolism Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Regulatory Elements, Transcriptional - genetics Reverse Transcriptase Polymerase Chain Reaction Trans-Activators - genetics Trans-Activators - metabolism
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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