SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin

Lung squamous cell carcinoma (LSCC) is a devastating malignancy with no effective treatments, due to its complex genomic profile. Therefore, preclinical models mimicking its salient features are urgently needed. Here we describe mouse models bearing various combinations of genetic lesions predominan...

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Bibliographic Details
Published in:	Cancer cell Vol. 30; no. 4; pp. 519 - 532
Main Authors:	Ferone, Giustina, Song, Ji-Ying, Sutherland, Kate D, Bhaskaran, Rajith, Monkhorst, Kim, Lambooij, Jan-Paul, Proost, Natalie, Gargiulo, Gaetano, Berns, Anton
Format:	Journal Article
Language:	English
Published:	United States 10.10.2016
Subjects:	Animals Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Proliferation - genetics Disease Models, Animal Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Receptor, Fibroblast Growth Factor, Type 1 - biosynthesis Receptor, Fibroblast Growth Factor, Type 1 - genetics SOXB1 Transcription Factors - genetics Transcription, Genetic Tumor Microenvironment
ISSN:	1878-3686
Online Access:	Get more information
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