The multifaceted role of podoplanin expression in hepatocellular carcinoma

The role of podoplanin in hepatocellular carcinoma (HCC) is not clear yet. The aim of our study was to evaluate the expression of podoplanin in HCC and to determine its role in hepatocarcinogenesis. We performed immunohistochemistry with monoclonal D2-40 antibody, on paraffin-embedded tissue section...

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Vydáno v:European journal of histochemistry Ročník 61; číslo 1; s. 2707
Hlavní autoři: Cioca, Andreea, Ceausu, Amalia R., Marin, Irina, Raica, Marius, Cimpean, Anca M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Italy PAGEPress Scientific Publications, Pavia, Italy 13.02.2017
PAGEPress Publications, Pavia, Italy
PAGEPress Publications
Témata:
Adult
Aged
Aged, 80 and over
cancer associated fibroblasts
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Female
Gene Expression Regulation, Neoplastic
Hepatocellular carcinoma
Humans
Immunohistochemistry
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
lymphatic vessel density
Male
Membrane Glycoproteins - biosynthesis
Middle Aged
Neoplasm Invasiveness
Neoplasm Proteins - biosynthesis
Original Paper
podoplanin
ISSN:1121-760X, 2038-8306, 2038-8306
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Popis
Shrnutí:The role of podoplanin in hepatocellular carcinoma (HCC) is not clear yet. The aim of our study was to evaluate the expression of podoplanin in HCC and to determine its role in hepatocarcinogenesis. We performed immunohistochemistry with monoclonal D2-40 antibody, on paraffin-embedded tissue sections of 72 patients diagnosed with HCC. Lymphatic vessels density (LVD) was increased in patients who had vascular invasion at the time of diagnosis (P=0.018) and in those with associated cirrhosis (P=0.006). Tumor cells showing podoplanin expression were correlated with histological grade (P=0.040). Podoplanin-expressing cancer associated fibroblasts (CAFs) were correlated with both LVD (P=0.019) and tumor cells (P=0.015). Our results sustain the dual role of podoplanin in HCC by its involvement in both HCC tumorigenesis, lymphatic neovascularization and tumor invasion invasiveness. A possible crosstalk between epithelial and stromal tumor cells in HCC tumor microenvironment may be mediated by podoplanin, but this hypothesis needs further studies to elucidate this interrelation.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1121-760X
2038-8306
2038-8306
DOI:10.4081/ejh.2017.2707