Novel application of one-step pooled molecular testing and maximum likelihood approaches to estimate the prevalence of malaria parasitaemia among rapid diagnostic test negative samples in western Kenya

Background Detection of malaria parasitaemia in samples that are negative by rapid diagnostic tests (RDTs) requires resource-intensive molecular tools. While pooled testing using a two-step strategy provides a cost-saving alternative to the gold standard of individual sample testing, statistical adj...

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Bibliographic Details
Published in:	Malaria journal Vol. 21; no. 1; pp. 319 - 11
Main Authors:	Shah, Monica P., Chebore, Winnie, Lyles, Robert H., Otieno, Kephas, Zhou, Zhiyong, Plucinski, Mateusz, Waller, Lance A., Odongo, Wycliffe, Lindblade, Kim A., Kariuki, Simon, Samuels, Aaron M., Desai, Meghna, Mitchell, Rebecca M., Shi, Ya Ping
Format:	Journal Article
Language:	English
Published:	London BioMed Central 06.11.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Biomedical and Life Sciences Biomedicine Blood & organ donations Clinical Trials as Topic Cost control Diagnostic tests Diagnostic Tests, Routine Entomology Estimates Group testing Human diseases Humans Infections Infectious Diseases Kenya - epidemiology Laboratories Likelihood Functions Malaria Malaria - diagnosis Malaria - epidemiology Malaria, Falciparum - epidemiology Microbiology Microscopy Molecular Diagnostic Techniques Nucleotide sequence Parasitemia - diagnosis Parasitemia - epidemiology Parasites Parasitology Polymerase chain reaction Pooled testing Prevalence Public Health Random sampling Sensitivity and Specificity Specificity Subpatent malaria parasitemia Testing Trends Tropical Medicine Validation studies Vector-borne diseases Kenya United States > US Group testing Pooled testing Subpatent malaria parasitemia
ISSN:	1475-2875, 1475-2875
Online Access:	Get full text
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