Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Protein SUMOylation is crucial for maintaining the hallmarks of cancer stem cells, including self‐renewal and active pluripotency gene networks. While inhibiting key steps of the SUMOylation cascade has been shown to suppress tumorigenesis, the specific mechanisms of SUMO dependency in cancer have n...

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Veröffentlicht in:	Molecular oncology Jg. 19; H. 8; S. 2166 - 2170
Hauptverfasser:	Yevdokimova, Veronika, Benoit, Yannick D.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States John Wiley & Sons, Inc 01.08.2025 John Wiley and Sons Inc Wiley
Schlagworte:	Animals B cells Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer and Oncology Cancer Stem Cells chromatin regulation Colorectal cancer drug discovery Enzymes Female Genetic engineering Genetically modified organisms Humans Leukemia Lymphoma Mammary gland Medical research Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Pancreatic cancer Pluripotency Proteases Small Ubiquitin-Related Modifier Proteins - metabolism Stem cells SUMO protein SUMOylation Transcription factors Transcription Factors - metabolism Tumorigenesis Tumors breast cancer SUMOylation cancer stem cells drug discovery chromatin regulation
ISSN:	1574-7891, 1878-0261, 1878-0261
Online-Zugang:	Volltext
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