Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

ABSTRACT Background Nicotinamide riboside (NR) is an NAD+ precursor that boosts cellular NAD+ concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. Objectives We aimed to investigate the effects of 6 wk NR supplementation on insulin sensitivity, m...

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Vydáno v:	The American journal of clinical nutrition Ročník 112; číslo 2; s. 413 - 426
Hlavní autoři:	Remie, Carlijn M E, Roumans, Kay H M, Moonen, Michiel P B, Connell, Niels J, Havekes, Bas, Mevenkamp, Julian, Lindeboom, Lucas, de Wit, Vera H W, van de Weijer, Tineke, Aarts, Suzanne A B M, Lutgens, Esther, Schomakers, Bauke V, Elfrink, Hyung L, Zapata-Pérez, Rubén, Houtkooper, Riekelt H, Auwerx, Johan, Hoeks, Joris, Schrauwen-Hinderling, Vera B, Phielix, Esther, Schrauwen, Patrick
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Oxford University Press 01.08.2020
Témata:	Acetylcarnitine - metabolism Aged Body Composition - drug effects Dietary Supplements - analysis Female Humans Male Middle Aged Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism NAD - biosynthesis Niacinamide - administration & dosage Niacinamide - analogs & derivatives Obesity - drug therapy Obesity - metabolism Obesity - physiopathology Overweight - drug therapy Overweight - metabolism Overweight - physiopathology Pyridinium Compounds NAD insulin sensitivity metabolic health mitochondrial function body composition acetylcarnitine nicotinamide riboside human obesity
ISSN:	0002-9165, 1938-3207, 1938-3207
On-line přístup:	Získat plný text
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