Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Exosomes are lipid-bilayer-enclosed extracellular vesicles that contain proteins and nucleic acids. They are secreted by all cells and circulate in the blood. Specific detection and isolation of cancer-cell-derived exosomes in the circulation is currently lacking. Using mass spectrometry analyses, w...

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Bibliographic Details
Published in:	Nature (London) Vol. 523; no. 7559; pp. 177 - 182
Main Authors:	Melo, Sonia A., Luecke, Linda B., Kahlert, Christoph, Fernandez, Agustin F., Gammon, Seth T., Kaye, Judith, LeBleu, Valerie S., Mittendorf, Elizabeth A., Weitz, Juergen, Rahbari, Nuh, Reissfelder, Christoph, Pilarsky, Christian, Fraga, Mario F., Piwnica-Worms, David, Kalluri, Raghu
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.07.2015 Nature Publishing Group
Subjects:	13/1 13/106 13/109 13/31 14/1 14/19 14/28 14/63 38/77 38/90 59/57 631/67/1504/1713 64/110 64/60 692/53/2421 692/53/2422 82/58 Animals Antigens Biomarkers Biomarkers - blood Cancer Cell Line, Tumor Deoxyribonucleic acid Diagnosis Diagnostic tests DNA Exosomes - genetics Exosomes - metabolism Female Glypicans - blood Glypicans - metabolism HCT116 Cells Humanities and Social Sciences Humans Male Mass spectrometry MCF-7 Cells Mice multidisciplinary Mutation NIH 3T3 Cells Nucleic acids Pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - pathology Patients Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) ras Proteins - metabolism Science Tumors
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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