Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes

Kinetoplastid parasites cause lethal diseases in humans and animals. The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA network that is also an important drug target. Isometamidium, for example, is a key veterinary drug that accumulates in the kinetoplast in Afr...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 29; p. 9112
Main Authors:	Baker, Nicola, Hamilton, Graham, Wilkes, Jonathan M, Hutchinson, Sebastian, Barrett, Michael P, Horn, David
Format:	Journal Article
Language:	English
Published:	United States 21.07.2015
Subjects:	Acids - metabolism Animals Cell Compartmentation - drug effects DNA, Kinetoplast - metabolism Drug Resistance - drug effects Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Intracellular Membranes - drug effects Intracellular Membranes - metabolism Mitochondria - drug effects Mitochondria - enzymology Phenanthridines - chemistry Phenanthridines - pharmacology Polymerase Chain Reaction Protein Subunits - metabolism Proton-Translocating ATPases - metabolism Reproducibility of Results RNA Interference - drug effects Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - enzymology Trypanosoma brucei brucei - genetics Vacuolar Proton-Translocating ATPases - metabolism samorin brucei nagana mitochondrion petite
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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