A Dedicated Population for Reward Coding in the Hippocampus

The hippocampus plays a critical role in goal-directed navigation. Across different environments, however, hippocampal maps are randomized, making it unclear how goal locations could be encoded consistently. To address this question, we developed a virtual reality task with shifting reward contingen...

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Podrobná bibliografia
Vydané v:	Neuron (Cambridge, Mass.) Ročník 99; číslo 1; s. 179
Hlavní autori:	Gauthier, Jeffrey L, Tank, David W
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 11.07.2018
Predmet:	Animals CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - diagnostic imaging CA1 Region, Hippocampal - physiology Hippocampus - cytology Hippocampus - diagnostic imaging Hippocampus - physiology Mice Motivation Neurons - cytology Neurons - physiology Optical Imaging Reward Spatial Navigation - physiology Task Performance and Analysis Virtual Reality place fields reward CA1 navigation virtual reality hippocampus place cells subiculum
ISSN:	1097-4199, 1097-4199
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Popis
Shrnutí:	The hippocampus plays a critical role in goal-directed navigation. Across different environments, however, hippocampal maps are randomized, making it unclear how goal locations could be encoded consistently. To address this question, we developed a virtual reality task with shifting reward contingencies to distinguish place versus reward encoding. In mice performing the task, large-scale recordings in CA1 and subiculum revealed a small, specialized cell population that was only active near reward yet whose activity could not be explained by sensory cues or stereotyped reward anticipation behavior. Across different virtual environments, most cells remapped randomly, but reward encoding consistently arose from a single pool of cells, suggesting that they formed a dedicated channel for reward. These observations represent a significant departure from the current understanding of CA1 as a relatively homogeneous ensemble without fixed coding properties and provide a new candidate for the cellular basis of goal memory in the hippocampus.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1097-4199 1097-4199
DOI:	10.1016/j.neuron.2018.06.008