Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype

The presence of atherosclerotic plaque vessels is a critical factor in plaque destabilization. This may be attributable to the leaky phenotype of these microvessels, although direct proof for this notion is lacking. In this study, we investigated molecular and cellular patterns of stable and hemorrh...

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Published in:	Angiogenesis (London) Vol. 27; no. 3; pp. 461 - 474
Main Authors:	Rademakers, Timo, Manca, Marco, Jin, Han, Orban, Tanguy, Perisic, Ljubica Matic, Frissen, Hubertus J. M., Rühle, Frank, Hautvast, Petra, van Rijssel, Jos, van Kuijk, Kim, Mees, Barend M. E., Peutz-Kootstra, Carine J., Heeneman, Sylvia, Daemen, Mat J. A. P., Pasterkamp, Gerard, Stoll, Monika, van Zandvoort, Marc A. M. J., Hedin, Ulf, Dequiedt, Franck, van Buul, Jaap D., Sluimer, Judith C., Biessen, Erik A. L.
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01.08.2024 Springer Nature B.V Springer Science and Business Media B.V
Subjects:	Animals Arteriosclerosis Atherosclerosis Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Biomedical and Life Sciences Biomedicine Blood vessels Cancer Research Capillary Permeability Capillary Permeability - genetics Cardiology Cardiovascular diseases Cell Biology Clinical Biochemistry Correlation Destabilization Endothelial cells Gene expression Genotype & phenotype Heart diseases Hemorrhage Human Umbilical Vein Endothelial Cells Human Umbilical Vein Endothelial Cells - metabolism Humans In vivo methods and tests Leaky vessels Leukocyte migration Life sciences Microvasculature Microvessels Microvessels - metabolism Microvessels - pathology Modules Oncology Ophthalmology Original Paper Phenotype Phenotypes Physiology Plaque microvessels Plaque, Atherosclerotic Plaque, Atherosclerotic - genetics Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Sciences du vivant Spectrin Spectrin - genetics Spectrin - metabolism SPTBN1 protein, human Stiffness Substrates Transcriptome Transcriptome - genetics Transcriptomes Transcriptomics Vascular biology Zebrafish Zebrafish - genetics Stiffness Plaque microvessels Leaky vessels Vascular biology Atherosclerosis
ISSN:	0969-6970, 1573-7209, 1573-7209
Online Access:	Get full text
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