Widespread lateral gene transfer from intracellular bacteria to multicellular eukaryotes

Although common among bacteria, lateral gene transfer-the movement of genes between distantly related organisms-is thought to occur only rarely between bacteria and multicellular eukaryotes. However, the presence of endosymbionts, such as Wolbachia pipientis, within some eukaryotic germlines may fac...

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Vydáno v:Science (American Association for the Advancement of Science) Ročník 317; číslo 5845; s. 1753
Hlavní autoři: Dunning Hotopp, Julie C, Clark, Michael E, Oliveira, Deodoro C S G, Foster, Jeremy M, Fischer, Peter, Muñoz Torres, Mónica C, Giebel, Jonathan D, Kumar, Nikhil, Ishmael, Nadeeza, Wang, Shiliang, Ingram, Jessica, Nene, Rahul V, Shepard, Jessica, Tomkins, Jeffrey, Richards, Stephen, Spiro, David J, Ghedin, Elodie, Slatko, Barton E, Tettelin, Hervé, Werren, John H
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 21.09.2007
Témata:
Animals
Chromosome Mapping
Crosses, Genetic
DNA, Bacterial
Drosophila - genetics
Drosophila - microbiology
Female
Gene Transfer, Horizontal
Genes, Bacterial
In Situ Hybridization, Fluorescence
Insecta - genetics
Insecta - microbiology
Male
Molecular Sequence Data
Nematoda - genetics
Nematoda - microbiology
Retroelements
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Symbiosis
Wolbachia - genetics
ISSN:1095-9203, 1095-9203
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Shrnutí:Although common among bacteria, lateral gene transfer-the movement of genes between distantly related organisms-is thought to occur only rarely between bacteria and multicellular eukaryotes. However, the presence of endosymbionts, such as Wolbachia pipientis, within some eukaryotic germlines may facilitate bacterial gene transfers to eukaryotic host genomes. We therefore examined host genomes for evidence of gene transfer events from Wolbachia bacteria to their hosts. We found and confirmed transfers into the genomes of four insect and four nematode species that range from nearly the entire Wolbachia genome (>1 megabase) to short (<500 base pairs) insertions. Potential Wolbachia-to-host transfers were also detected computationally in three additional sequenced insect genomes. We also show that some of these inserted Wolbachia genes are transcribed within eukaryotic cells lacking endosymbionts. Therefore, heritable lateral gene transfer occurs into eukaryotic hosts from their prokaryote symbionts, potentially providing a mechanism for acquisition of new genes and functions.
Bibliografie:ObjectType-Article-1
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.1142490