Co-occurrence of antibiotic and metal resistance genes revealed in complete genome collection

The high frequency of antibiotic resistance is a global public health concern. More seriously, widespread metal pressure in the environment may facilitate the proliferation of antibiotic resistance via coselection of antibiotic resistance genes (ARGs) and metal resistance genes (MRGs). Given the lac...

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Bibliographic Details
Published in:The ISME Journal Vol. 11; no. 3; pp. 651 - 662
Main Authors: Li, Li-Guan, Xia, Yu, Zhang, Tong
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.03.2017
Oxford University Press
Nature Publishing Group
Subjects:
45/43
631/208/212
631/326/41/2530
Anthropogenic factors
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Bacteria - classification
Bacteria - drug effects
Bacteria - genetics
Bacterial Infections - microbiology
Biomedical and Life Sciences
Drug Resistance, Bacterial
Drug Resistance, Microbial
Ecology
Evolutionary Biology
Flora
Genes, Bacterial
Genome, Bacterial
Humans
Life Sciences
Metals - pharmacology
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Original
original-article
Pathogens
Public health
ISSN:1751-7362, 1751-7370
Online Access:Get full text
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Summary:The high frequency of antibiotic resistance is a global public health concern. More seriously, widespread metal pressure in the environment may facilitate the proliferation of antibiotic resistance via coselection of antibiotic resistance genes (ARGs) and metal resistance genes (MRGs). Given the lack of comprehensive understanding of the ARG and MRG coselection, in this study both abundance relationship and genetic linkage between ARGs and MRGs were rigorously investigated by performing a genomic analysis of a large complete genome collection. Many more ARGs were enriched in human-associated bacteria compared with those subjected to less anthropogenic interference. The signatures of ARG and MRG co-occurrence were much more frequent and the distance linkages between ARGs and MRGs were much more intimate in human pathogens than those less human-associated bacteria. Moreover, the co-occurrence structures in the habitat divisions were significantly different, which could be attributed to their distinct gene transfer potentials. More exogenous ARGs and MRGs on the genomes of human pathogens indicated the importance of recent resistance acquisition in resistome development of human commensal flora. Overall, the study emphasizes the potential risk associated with ARG and MRG coselection of both environmental and medical relevance.
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These authors contributed equally to this work.
ISSN:1751-7362
1751-7370
DOI:10.1038/ismej.2016.155